Patents by Inventor Kevin K. Liu
Kevin K. Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110028452Abstract: The present invention is directed to novel pyrido[4,3-d]pyrimidin-4(3H)-one derivatives and pharmaceutically acceptable salts thereof of structural formula I wherein the variables R1, R2, R3, R4 and R5 are as described herein. Also provided are pharmaceutical compositions comprising the compounds of formula I as well as methods of treatment employing compounds of formula I to treat a disease or disorder characterized by abnormal bone or mineral homeostasis such as hypoparathyroidism, osteoporosis, osteopenia, periodontal disease, Paget's disease, bone fracture, osteoarthritis, rheumatoid arthritis, and humoral hypercalcemia of malignancy.Type: ApplicationFiled: September 30, 2010Publication date: February 3, 2011Inventors: Mary T. Didiuk, Kevin K. Liu, David A. Griffith, Angel Guzman-Perez, Feng C. Bi, Daniel P. Walker
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Patent number: 7829572Abstract: The present invention is directed to novel pyrido[4,3-d]pyrimidin-4(3H)-one derivatives and pharmaceutically acceptable salts thereof of structural formula I wherein the variables R1, R2, R3, R4 and R5 are as described herein. Also provided are pharmaceutical compositions comprising the compounds of formula I as well as methods of treatment employing compounds of formula I to treat a disease or disorder characterized by abnormal bone or mineral homeostasis such as hypoparathyroidism, osteoporosis, osteopenia, periodontal disease, Paget's disease, bone fracture, osteoarthritis, rheumatoid arthritis, and humoral hypercalcemia of malignancy.Type: GrantFiled: October 4, 2007Date of Patent: November 9, 2010Assignee: Pfizer IncInventors: Mary T. Didiuk, Kevin K. Liu, David A. Griffith, Angel Guzman-Perez, Feng C. Bi, Daniel P. Walker
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Patent number: 7723643Abstract: A laser peening process for the densification of metal surfaces and sub-layers and for changing surface chemical activities provides retardation of the up-take and penetration of atoms and molecules, particularly Hydrogen, which improves the lifetime of such laser peened metals. Penetration of hydrogen into metals initiates an embrittlement that leaves the material susceptible to cracking.Type: GrantFiled: April 6, 2006Date of Patent: May 25, 2010Assignees: Lawrence Livermore National Security, LLC, University of CaliforniaInventors: Lloyd A. Hackel, Tania M. Zaleski, Hao-Lin Chen, Michael R. Hill, Kevin K. Liu
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Patent number: 7713989Abstract: The present invention provides non-steroidal compounds of formula I which are selective modulators (i.e., agonists and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides pharmaceutical compositions containing these compounds and methods for using these compounds to treat animals requiring glucocorticoid receptor agonist or antagonist therapy. Glucocorticoid receptor modulators are useful to the diseases, such as obesity, diabetes, inflammation and others as described below. The present invention also provides intermediates and processes for preparing these compounds.Type: GrantFiled: October 13, 2006Date of Patent: May 11, 2010Inventors: Robert L. Dow, Kevin K. Liu, Bradley P. Morgan, Andrew G. Swick
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Patent number: 7351567Abstract: The present invention relates to a process for preparing 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen-2-ol compounds useful as an estrogen agonist.Type: GrantFiled: March 2, 2004Date of Patent: April 1, 2008Assignee: Pfizer Inc.Inventor: Kevin K. Liu
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Patent number: 7166593Abstract: The present invention provides non-steroidal compounds of formula I which are selective modulators (i.e., agonist and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides pharmaceutical compositions containing these compounds and methods for using these compounds to treat animals requiring glucocorticoid receptor agonist or antagonist therapy. Glucocorticoid receptor modulators are useful to treat diseases, such as obesity, diabetes, inflammation and others as described below.Type: GrantFiled: November 25, 2003Date of Patent: January 23, 2007Assignee: Pfizer, Inc.Inventors: Robert L. Dow, Kevin K. Liu, Bradley P. Morgan, Andrew G. Swick
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Patent number: 6894050Abstract: Compounds of Formula (IA) that act as 5-HT receptor ligands and their uses in the treatment of diseases linked to the activation of 5-HT2 receptors in animals are described hereinType: GrantFiled: June 5, 2002Date of Patent: May 17, 2005Assignee: Pfizer Inc.Inventors: Phoebe Chiang, William A. Novomisle, Willard M. Welch, Jr., Angel Guzman-Perez, Paul A. DaSilva-Jardine, Ravi S. Garigipati, Kevin K. Liu
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Patent number: 6852719Abstract: The present invention provides non-steroidal compounds of Formula I, including prodrugs and pharmaceutically acceptable salts thereof, which are selective modulators (e.g., agonists, partial agonists and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides pharmaceutical compositions containing these compounds and methods for using these compounds to treat animals requiring glucocorticoid receptor agonist or antagonist therapy. Glucocorticoid receptor modulators are useful to treat diseases, such as obesity, diabetes, inflammation and others as described below.Type: GrantFiled: October 26, 2001Date of Patent: February 8, 2005Assignees: Pfizer Inc., Pfizer Products, Inc.Inventors: Kevin K. Liu, Bradley P. Morgan, Ralph P. Robinson
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Patent number: 6828134Abstract: The present invention relates to a process for preparing 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen-2-ol compounds useful as an estrogen agonist.Type: GrantFiled: May 7, 2001Date of Patent: December 7, 2004Assignee: Pfizer Inc.Inventor: Kevin K. Liu
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Publication number: 20040176415Abstract: The present invention relates to a process for preparing 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen-2-ol compounds useful as an estrogen agonist.Type: ApplicationFiled: March 2, 2004Publication date: September 9, 2004Applicant: Pfizer Inc.Inventor: Kevin K. Liu
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Publication number: 20040176595Abstract: The present invention provides non-steroidal compounds of formula I which are selective modulators (i.e., agonist and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides pharmaceutical compositions containing these compounds and methods for using these compounds to treat animals requiring glucocorticoid receptor agonist or antagonist therapy. Glucocorticoid receptor modulators are useful to treat diseases, such as obesity, diabetes, inflammation and others as described below. The present invention also provides intermediates and processes for preparing these compounds.Type: ApplicationFiled: November 25, 2003Publication date: September 9, 2004Applicant: Pfizer, Inc.Inventors: Robert L. Dow, Kevin K. Liu, Bradley P. Morgan, Andrew G. Swick
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Patent number: 6699893Abstract: The present invention provides non-steroidal compounds of formula I which are selective modulators (i.e., agonists and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides pharmaceutical compositions containing these compounds and methods for using these compounds to treat animals requiring glucocorticoid receptor agonist or antagonist therapy. Glucocorticoid receptor modulators are useful to treat diseases, such as obesity, diabetes, inflammation and others as described below. The present invention also provides intermediates and processes for preparing these compounds.Type: GrantFiled: February 19, 2002Date of Patent: March 2, 2004Assignee: Pfizer IncInventors: Robert L. Dow, Kevin K. Liu, Bradley P. Morgan, Andrew G. Swick
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Publication number: 20040014741Abstract: The present invention provides non-steroidal compounds of Formula I, including prodrugs and pharmaceutically acceptable salts thereof, which are selective modulators (e.g., agonists, partial agonists and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides pharmaceutical compositions containing these compounds and methods for using these compounds to treat animals requiring glucocorticoid receptor agonist or antagonist therapy. Glucocorticoid receptor modulators are useful to treat diseases, such as obesity, diabetes, inflammation and others as described below. The present invention also provides processes for preparing these compounds.Type: ApplicationFiled: October 26, 2001Publication date: January 22, 2004Inventors: Kevin K. Liu, Bradley P. Morgan, Ralph P. Robinson
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Publication number: 20030125334Abstract: Compounds of Formula (IA) that act as 5-HT receptor ligands and their uses in the treatment of diseases linked to the activation of 5-HT2 receptors in animals are described herein.Type: ApplicationFiled: June 5, 2002Publication date: July 3, 2003Inventors: Phoebe Chiang, William A. Novomisle, Willard M. Welch, Angel Guzman-Perez, Paul A. DaSilva-Jardine, Ravi S. Garigipati, Kevin K. Liu
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Publication number: 20020147336Abstract: The present invention provides non-steroidal compounds of formula I which are selective modulators (i.e., agonists and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides pharmaceutical compositions containing these compounds and methods for using these compounds to treat animals requiring glucocorticoid receptor agonist or antagonist therapy. Glucocorticoid receptor modulators are useful to treat diseases, such as obesity, diabetes, inflammation and others as described below. The present invention also provides intermediates and processes for preparing these compounds.Type: ApplicationFiled: February 19, 2002Publication date: October 10, 2002Inventors: Robert L. Dow, Kevin K. Liu, Bradley P. Morgan, Andrew G. Swick
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Patent number: 6438006Abstract: A voltage multiplying circuit including a multiphase power stage and at least one phased voltage multiplier stage connected to the multiphase power stage.Type: GrantFiled: September 25, 2000Date of Patent: August 20, 2002Assignee: L-3 Communications CorporationInventors: Hubert C. Martin, Robert H. Peterson, Kevin K. Liu, Steven W. Wiscomb, Larry N. Mercer, Matthew R. Reed, Parry L. Cowdell
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Publication number: 20020107235Abstract: The present invention provides non-steroidal compounds of Formula I, and prodrugs and pharmaceutically acceptable salts thereof, which are selective modulators (e.g., agonists, partial agonists and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides pharmaceutical compositions containing these compounds and methods for using these compounds to treat animals requiring glucocorticoid receptor agonist or antagonist therapy. Glucocorticoid receptor modulators are useful to treat diseases, such as obesity, diabetes, inflammation and others as described below. The present invention also provides processes for preparing these compounds.Type: ApplicationFiled: October 26, 2001Publication date: August 8, 2002Inventors: Kevin K. Liu, Bradley P. Morgan, Ralph P. Robinson
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Patent number: 6380223Abstract: The present invention provides non-steroidal compounds of formula I which are selective modulators (i.e., agonists and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides pharmaceutical compositions containing these compounds and methods for using these compounds to treat animals requiring glucocorticoid receptor agonist or antagonist therapy. Glucocorticoid receptor modulators are useful to treat diseases, such as obesity, diabetes, inflammation and others as described below. The present invention also provides intermediates and processes for preparing these compounds.Type: GrantFiled: April 27, 2000Date of Patent: April 30, 2002Assignee: Pfizer Inc.Inventors: Robert L. Dow, Kevin K. Liu, Bradley P. Morgan, Andrew G. Swick
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Publication number: 20020049219Abstract: The present invention relates to a process for preparing 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen-2-ol compounds useful as an estrogen agonist.Type: ApplicationFiled: May 7, 2001Publication date: April 25, 2002Inventor: Kevin K. Liu