Abstract: A novel gRNA-ligand binding complex is provided. This complex may be used to bring Type V Cas proteins and additional effectors to DNA for base editing. The design of the systems allows for the production of efficient modular components that provide flexibility when editing DNA.

Abstract: A coupled shaft assembly for a foundation support system includes inner and outer couplers with mating helical ribs and grooves, and spring element that resiliently interlocks the inner and outer couplers in an axial direction. Built-in anti-reverse rotation elements in each coupler accommodates a limited degree of relative rotation of the couplers and thereafter precludes further relative rotation that could otherwise negatively impact the spring element and lead to an undesirable disengagement of the inner and outer couplers.

Abstract: A coupled shaft assembly for a foundation support system includes conical-shaped inner and outer couplers with mating helical ribs and grooves, and an anti-reverse element extending through different shaped openings in the inner and outer couplers that accommodates a limited degree of relative rotation of the couplers and thereafter precludes further relative rotation and an undesirable disengagement of the inner and outer couplers when subjected to reverse rotation.

Abstract: Coupled shaft assemblies for a foundation support system include shafts provided with profiled distal end edges that may be directly engaged to one another to realize an interlocking torque transmitting relationship with one another along a curved engagement surface. A coupler sleeve may snugly receive the distal ends of the directly engaged shafts and may fasten the shafts to one another through the coupler sleeve with ease in an economical manufacture that does not require non-uniform wall thickness in the shafts to establish torque transmission capability.

Abstract: A modular foundation support system includes modular foundation support components including shafts provided with integrally formed coupler features on their respective distal ends. The coupler features are configured with a non-uniform wall thickness defining a plurality of sections of respectively different diameter to matingly couple the shafts to one another in a torque transmitting relationship. The coupler features may be integrally formed and fabricated on the distal end of each respective shaft.

Abstract: A modular foundation support system includes modular foundation support components including self-aligning and torque transmitting coupler features wherein a plurality of\elongated ribs are aligned with a plurality of elongated grooves to rotationally interlock the modular foundation support components to one another.

Abstract: A lift bracket system for lifting a building structure such as a foundation and the like comprising a lift plate having a top surface and a bottom surface, the top surface for insertion under the building structure; a generally cylindrical housing affixed to the lift plate and extending perpendicularly from the top surface and the bottom surface of the lift plate, the housing defining a generally circular opening through the lift plate, the opening being disposed away from the center of the lift plate; and at least one gusset for supporting the lift plate, the gusset having a first end and a second end, the gusset disposed beneath the lift plate, wherein the first end of the gusset is attached to the bottom surface of the lift plate and the second end of the gusset is attached to the housing.

Abstract: A modular foundation support system includes modular foundation support components including self-aligning and torque transmitting coupler features wherein a plurality of axially elongated ribs are aligned with a plurality of axially elongated ribs to rotationally interlocke the modular foundation support components to one another.

Abstract: A lift bracket system for lifting a building structure such as a foundation and the like comprising a lift plate having a top surface and a bottom surface, the top surface for insertion under the building structure; a generally cylindrical housing affixed to the lift plate and extending perpendicularly from the top surface and the bottom surface of the lift plate, the housing defining a generally circular opening through the lift plate, the opening being disposed away from the center of the lift plate; and at least one gusset for supporting the lift plate, the gusset having a first end and a second end, the gusset disposed beneath the lift plate, wherein the first end of the gusset is attached to the bottom surface of the lift plate and the second end of the gusset is attached to the housing.

Abstract: Improved couplers for a building foundation support system include helical ribs and helical grooves in combination with an integrated spring retainer element that automatically snaps into place as the couplers are engaged. Rotational and axial interlocking attachment of support piles is therefore possible without utilizing separately provided fasteners such as bolts.

Abstract: A modular foundation support system includes modular foundation support components including self-aligning and torque transmitting coupler features wherein a plurality of axially elongated ribs are aligned with a plurality of axially elongated ribs to rotationally interlocke the modular foundation support components to one another.

Abstract: A modular foundation support system includes modular foundation support components including self-aligning and torque transmitting coupler features wherein a plurality of axially elongated ribs are aligned with a plurality of axially elongated ribs on a second distal end to rotationally interlocked the modular foundation support components to one another. First and second pair of fastener holes are self-aligning with one another to receive a fastener therethrough such that the fastener is mechanically isolated from rotational torque transmission.

Abstract: This disclosure presents various embodiments of a transforaminal intersomatic cage for an intervertebral fusion graft, and an instrument and method for implanting the cage, an embodiment of the cage having a body in the shape of a circular arc and comprising a lateral concave surface, a lateral convex surface, a straight upper surface, a straight lower surface and an end wall having at least one hole, called the end hole, designed to receive a rod of an instrument for implanting the cage between the vertebrae, wherein: the end hole has an orientation that is more or less tangential to the circular arc described by the body; the extremity opposite to the end wall of the body includes a return part extending the body toward the center of the circle on which the circular arc described by the body lies.

Abstract: A lift bracket system for lifting a building structure such as a foundation and the like comprising a lift plate having a top surface and a bottom surface, the top surface for insertion under the building structure; a generally cylindrical housing affixed to the lift plate and extending perpendicularly from the top surface and the bottom surface of the lift plate, the housing defining a generally circular opening through the lift plate, the opening being disposed away from the center of the lift plate; and at least one gusset for supporting the lift plate, the gusset having a first end and a second end, the gusset disposed beneath the lift plate, wherein the first end of the gusset is attached to the bottom surface of the lift plate and the second end of the gusset is attached to the housing.

Abstract: A lift bracket system for lifting a building structure such as a foundation and the like comprising a lift plate having a top surface and a bottom surface, the top surface for insertion under the building structure; a generally cylindrical housing affixed to the lift plate and extending perpendicularly from the top surface and the bottom surface of the lift plate, the housing defining a generally circular opening through the lift plate, the opening being disposed away from the center of the lift plate; and at least one gusset for supporting the lift plate, the gusset having a first end and a second end, the gusset disposed beneath the lift plate, wherein the first end of the gusset is attached to the bottom surface of the lift plate and the second end of the gusset is attached to the housing.

Abstract: A self-aligning and torque transmitting coupler assembly includes an outer coupler coupled to a first shaft of and an inner coupler coupled to a second shaft. The outer coupler comprises an inner surface having primary and secondary alignment and torque transmitting features, and the inner coupler comprises an outer surface having primary and secondary alignment features. The primary and secondary alignment features are configured to interlock and facilitate alignment of the first and second shafts along a common axis in an exemplary application of a foundation support system.

Abstract: A modular foundation support system includes modular foundation support components including self-aligning and torque transmitting coupler features wherein a plurality of axially elongated ribs are aligned with a plurality of axially elongated ribs on a second distal end to rotationally interlocked the modular foundation support components to one another. First and second pair of fastener holes are self-aligning with one another to receive a fastener therethrough such that the fastener is mechanically isolated from rotational torque transmission.

Abstract: A self-aligning and torque transmitting coupler assembly includes an outer coupler coupled to a first shaft of and an inner coupler coupled to a second shaft. The outer coupler comprises an inner surface having primary and secondary alignment and torque transmitting features, and the inner coupler comprises an outer surface having primary and secondary alignment features. The primary and secondary alignment features are configured to interlock and facilitate alignment of the first and second shafts along a common axis in an exemplary application of a foundation support system.

Abstract: This disclosure presents various embodiments of a transforaminal intersomatic cage for an intervertebral fusion graft, and an instrument and method for implanting the cage, an embodiment of the cage having a body in the shape of a circular arc and comprising a lateral concave surface, a lateral convex surface, a straight upper surface, a straight lower surface and an end wall having at least one hole, called the end hole, designed to receive a rod of an instrument for implanting the cage between the vertebrae, wherein: the end hole has an orientation that is more or less tangential to the circular arc described by the body; the extremity opposite to the end wall of the body includes a return part extending the body toward the center of the circle on which the circular arc described by the body lies.

Abstract: A self-aligning and torque transmitting coupler assembly includes an outer coupler coupled to a first shaft of and an inner coupler coupled to a second shaft. The outer coupler comprises an inner surface having primary and secondary alignment and torque transmitting features, and the inner coupler comprises an outer surface having primary and secondary alignment features. The primary and secondary alignment features are configured to interlock and facilitate alignment of the first and second shafts along a common axis in an exemplary application of a foundation support system.