Abstract: Methods of treating or slowing the growth of a lesion associated with geographic atrophy and methods of evaluating a drug or agent for use in treating, reducing the progression of or slowing the growth of a lesion associated with geographic atrophy.

Abstract: Methods of treating or slowing the growth of a lesion associated with geographic atrophy and methods of evaluating a drug or agent for use in treating, reducing the progression of or slowing the growth of a lesion associated with geographic atrophy.

Abstract: A pedestrian pushbutton for activating a traffic device. A plunger mounted in a housing impinges on a piezo element when pressed. O-rings between the bolts that secure the plunger to the housing and the housing bias the plunger inwardly. A foam disk under the piezo element, or a resilient stem bumper on the back of the plunger, or both, bias the plunger outwardly with a force about equal to the inwardly biasing force of the O-rings on the bolts. Thus, the opposing resilient members maintain the plunger at neutral buoyancy when at rest. An O-ring disposed between the edge of the plunger and the opening in the housing centers the plunger. The pushbutton may include light and sound assemblies to confirm to the pedestrian visually and audibly that the pushbutton has been engaged. The sound chamber may be tuned based on the Helmholtz formula to achieve an optimum frequency.

Abstract: A voltage translator with data buffer includes an input inverter receiving a data input signal at a first voltage level. A level shifting cross-coupled NOR circuit is coupled to the input inverter for translating the data input signal at a second voltage level. An output stage driven by the level shifting cross-coupled NOR circuit for providing a data output signal at the second voltage level. The voltage translator enables improved performance across various power, voltage and temperature (PVT) conditions and reliably reduces or minimizes shoot through current and delay.

Abstract: The present invention provides a dietary or food supplement for healthy humans that includes a combination of 4-hydroxyisoleucine and creatine, or nutraceutically acceptable derivatives of these two compounds. The supplement may include additives such as carbohydrates or amino acids. The invention further includes a regimen for supplementing a healthy athlete's diet by administering on a regular basis to the athlete 4-hydroxyisoleucine and creatine, or nutraceutically acceptable derivatives of these two compounds. The invention also provides a method for enhancing the body's absorption and utilization of a nutrient, comprising administering 4-hydroxyisoleucine or a nutraceutically acceptable derivative thereof in combination with the nutrient.

Abstract: The present invention provides a dietary or food supplement for healthy humans that includes a combination of 4-hydroxyisoleucine and creatine, or nutraceutically acceptable derivatives of these two compounds. The supplement may include additives such as carbohydrates or amino acids. The invention further includes a regimen for supplementing a healthy athlete's diet by administering on a regular basis to the athlete 4-hydroxyisoleucine and creatine, or nutraceutically acceptable derivatives of these two compounds. The invention also provides a method for enhancing the body's absorption and utilization of a nutrient, comprising administering 4-hydroxyisoleucine or a nutraceutically acceptable derivative thereof in combination with the nutrient.

Abstract: A digital CMOS predriver circuit pulls an output node up and down with accurately controlled rise and fall times in the threshold region. Resistors independently set rise and fall slew rates while additional CMOS devices initially charge and discharge the output node. The additional devices turn off before the output reaches the threshold region.