Abstract: Provided are isolated expanded human hepatocytes and methods of producing isolated expanded human hepatocytes. In certain embodiments, the methods comprise introducing human hepatocytes into the liver of a non-human in vivo bioreactor, expanding the human hepatocytes in the liver of the non-human in vivo bioreactor, and collecting hepatocytes from the liver of the non-human in vivo bioreactor. The collected hepatocytes comprise a xenomixture of expanded human hepatocytes and non-human in vivo bioreactor cells, including hepatocytes endogenous to the in vivo bioreactor. Such methods may further comprise subjecting the xenomixture to centrifugal elutriation under conditions sufficient to produce an elutriation fraction enriched for the expanded human hepatocytes, and/or removing non-human in vivo bioreactor cells from the elutriation fraction via a negative selection process. Also provided are isolated expanded human hepatocytes produced according to such methods.

Abstract: A ladder safety device for removably securing a ladder to a parapet wall of a rooftop, including: a pair of support clamps securable to the parapet wall, each said support clamp including a first support member, a second support member, and an extended arm joining said first support member to said second support member, wherein a distance between said support members defines a width adjustable to the width of the parapet wall; an elongate plate connecting said pair of support clamps to each other; and at least one ladder hook extending from said elongate plate for securely receiving a rung of the ladder.

Abstract: A ladder safety device (2) for removably securing a ladder (40) to a parapet wall (36) of a rooftop (38), including: a pair of support clamps (4) securable to the parapet wall (36), each said support clamp (4) including a first support member (10), a second support member (12), and an extended arm (14) joining said first support member (10) to said second support member (12), wherein a distance between said support members (10, 12) defines a width adjustable to the width of the parapet wall (36); an elongate plate (6) connecting said pair of support clamps (4) to each other; and at least one ladder hook (8) extending from said elongate plate (6) for securely receiving a rung of the ladder (40).

Abstract: A ladder safety device (2) for removably securing a ladder (40) to a parapet wall (36) of a rooftop (38), including: a pair of support clamps (4) securable to the parapet wall (36), each said support clamp (4) including a first support member (10), a second support member (12), and an extended arm (14) joining said first support member (10) to said second support member (12), wherein a distance between said support members (10, 12) defines a width adjustable to the width of the parapet wall (36); an elongate plate (6) connecting said pair of support clamps (4) to each other; and at least one ladder hook (8) extending from said elongate plate (6) for securely receiving a rung of the ladder (40).