Patents by Inventor Kevin Kilgore
Kevin Kilgore has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240132902Abstract: The present disclosure provides compositions and methods for producing transgenic plants and other organisms that exhibit increased production of mogroside compounds, in particular mogroside V, and the mogroside compounds, plants and plant parts so produced.Type: ApplicationFiled: September 18, 2023Publication date: April 25, 2024Inventors: Tengfang Huang, Jack Q. Wilkinson, Anna Matthiadis, Devarshi Selote, Matthew Kilgore, Matthew DiLeo, Fayaz Khazi, Kevin Potter, Daniel Stauffer, Todd Rands
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Patent number: 11065467Abstract: One aspect of the present disclosure relates a system that can quickly and reversibly block conduction in a nerve. The system can include a first nerve block modality that provides heat to the nerve to block conduction in the nerve. For example, the heat can provide the quick nerve block. The system can also include a second nerve block modality that provides an electrical signal to the nerve to block the conduction in the nerve. For example, the electrical signal can provide the reversibility. In some instances, the heat can be provided by an infrared light signal and the electrical signal can be provided by a kilohertz frequency alternating current (KHFAC) signal or a direct current (DC) signal.Type: GrantFiled: March 8, 2019Date of Patent: July 20, 2021Assignees: CASE WESTERN RESERVE UNIVERSITY, VANDERBILT UNIVERSITYInventors: Hillel Chiel, Niloy Bhadra, Mike Jenkins, Emilie Lothet, Tina Vrabec, Kevin Kilgore, Narendra Bhadra, Eric Duco Jansen
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Patent number: 10758738Abstract: One aspect of the present disclosure relates a system that can quickly and reversibly block conduction in a nerve. The system can include a first nerve block modality that provides heat to the nerve to block conduction in the nerve. For example, the heat can provide the quick nerve block. The system can also include a second nerve block modality that provides an electrical signal to the nerve to block the conduction in the nerve. For example, the electrical signal can provide the reversibility. In some instances, the heat can be provided by an infrared light signal and the electrical signal can be provided by a kilohertz frequency alternating current (KHFAC) signal or a direct current (DC) signal.Type: GrantFiled: March 17, 2015Date of Patent: September 1, 2020Assignees: CASE WESTERN RESERVE UNIVERSITY, VANDERBILT UNIVERSITYInventors: Hillel Chiel, Niloy Bhadra, Mike Jenkins, Emilie Lothet, Tina Vrabec, Kevin Kilgore, Narendra Bhadra, Eric Duco Jansen
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Patent number: 10456575Abstract: Example adjustable electrodes are described. One example adjustable electrode includes two or more contacts configured to selectively deliver high frequency alternating current (HFAC) to a nerve in an amount sufficient to produce an HFAC nerve conduction block in the nerve. The example adjustable electrode may also include a logic configured to selectively control which of the two or more contacts deliver HFAC to the nerve to control whether the nerve electrode is in a first (e.g., onset response mitigating) configuration or in a second (e.g., HFAC nerve conduction block maintenance) configuration. The electrode may be used in applications including, but not limited to, nerve block applications, and nerve stimulation applications. The electrode may be adjusted by changing attributes including, but not limited to, the number, length, orientation, distance between, surface area, and distance from a nerve of contacts to be used to deliver the HFAC.Type: GrantFiled: May 8, 2018Date of Patent: October 29, 2019Assignee: CASE WESTERN RESERVE UNIVERSITYInventors: Kevin Kilgore, Douglas Michael Ackermann, Jr., Niloy Bhadra, Narendra Bhadra, Joe Payer
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Publication number: 20190201703Abstract: One aspect of the present disclosure relates a system that can quickly and reversibly block conduction in a nerve. The system can include a first nerve block modality that provides heat to the nerve to block conduction in the nerve. For example, the heat can provide the quick nerve block. The system can also include a second nerve block modality that provides an electrical signal to the nerve to block the conduction in the nerve. For example, the electrical signal can provide the reversibility. In some instances, the heat can be provided by an infrared light signal and the electrical signal can be provided by a kilohertz frequency alternating current (KHFAC) signal or a direct current (DC) signal.Type: ApplicationFiled: March 8, 2019Publication date: July 4, 2019Inventors: Hillel Chiel, Niloy Bhadra, Mike Jenkins, Emilie Lothet, Tina Vrabec, Kevin Kilgore, Narendra Bhadra, Eric Duco Jansen
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Patent number: 10322293Abstract: One aspect of the present disclosure relates a system that can quickly and reversibly block conduction in a nerve. The system can include a first nerve block modality that provides heat to the nerve to block conduction in the nerve. For example, the heat can provide the quick nerve block. The system can also include a second nerve block modality that provides an electrical signal to the nerve to block the conduction in the nerve. For example, the electrical signal can provide the reversibility. In some instances, the heat can be provided by an infrared light signal and the electrical signal can be provided by a kilohertz frequency alternating current (KHFAC) signal or a direct current (DC) signal.Type: GrantFiled: October 15, 2018Date of Patent: June 18, 2019Assignees: CASE WESTERN RESERVE UNIVERSITY, VANDERBILT UNIVERSITYInventors: Hillel Chiel, Niloy Bhadra, Mike Jenkins, Emilie Lothet, Tina Vrabec, Kevin Kilgore, Narendra Bhadra, Eric Duco Jansen
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Publication number: 20190046807Abstract: One aspect of the present disclosure relates a system that can quickly and reversibly block conduction in a nerve. The system can include a first nerve block modality that provides heat to the nerve to block conduction in the nerve. For example, the heat can provide the quick nerve block. The system can also include a second nerve block modality that provides an electrical signal to the nerve to block the conduction in the nerve. For example, the electrical signal can provide the reversibility. In some instances, the heat can be provided by an infrared light signal and the electrical signal can be provided by a kilohertz frequency alternating current (KHFAC) signal or a direct current (DC) signal.Type: ApplicationFiled: October 15, 2018Publication date: February 14, 2019Inventors: Hillel Chiel, Niloy Bhadra, Mike Jenkins, Emilie Lothet, Tina Vrabec, Kevin Kilgore, Narendra Bhadra, Duco Jansen
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Publication number: 20180250506Abstract: Example adjustable electrodes are described. One example adjustable electrode includes two or more contacts configured to selectively deliver high frequency alternating current (HFAC) to a nerve in an amount sufficient to produce an HFAC nerve conduction block in the nerve. The example adjustable electrode may also include a logic configured to selectively control which of the two or more contacts deliver HFAC to the nerve to control whether the nerve electrode is in a first (e.g., onset response mitigating) configuration or in a second (e.g., HFAC nerve conduction block maintenance) configuration. The electrode may be used in applications including, but not limited to, nerve block applications, and nerve stimulation applications. The electrode may be adjusted by changing attributes including, but not limited to, the number, length, orientation, distance between, surface area, and distance from a nerve of contacts to be used to deliver the HFAC.Type: ApplicationFiled: May 8, 2018Publication date: September 6, 2018Inventors: Kevin Kilgore, Douglas Michael Ackermann, JR., Niloy Bhadra, Narendra Bhadra, Joe Payer
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Patent number: 10039917Abstract: Example adjustable electrodes are described. One example adjustable electrode includes two or more contacts configured to selectively deliver high frequency alternating current (HFAC) to a nerve in an amount sufficient to produce an HFAC nerve conduction block in the nerve. The example adjustable electrode may also include a logic configured to selectively control which of the two or more contacts deliver HFAC to the nerve to control whether the nerve electrode is in a first (e.g., onset response mitigating) configuration or in a second (e.g., HFAC nerve conduction block maintenance) configuration. The electrode may be used in applications including, but not limited to, nerve block applications, and nerve stimulation applications. The electrode may be adjusted by changing attributes including, but not limited to, the number, length, orientation, distance between, surface area, and distance from a nerve of contacts to be used to deliver the HFAC.Type: GrantFiled: April 29, 2016Date of Patent: August 7, 2018Assignee: Case Western Reserve UniversityInventors: Kevin Kilgore, Douglas Michael Ackermann, Jr., Niloy Bhadra, Narendra Bhadra, Joe Payer
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Publication number: 20170080244Abstract: One aspect of the present disclosure relates a system that can quickly and reversibly block conduction in a nerve. The system can include a first nerve block modality that provides heat to the nerve to block conduction in the nerve. For example, the heat can provide the quick nerve block. The system can also include a second nerve block modality that provides an electrical signal to the nerve to block the conduction in the nerve. For example, the electrical signal can provide the reversibility. In some instances, the heat can be provided by an infrared light signal and the electrical signal can be provided by a kilohertz frequency alternating current (KHFAC) signal or a direct current (DC) signal.Type: ApplicationFiled: March 17, 2015Publication date: March 23, 2017Inventors: Hillel Chiel, Niloy Bhadra, Mike Jenkins, Emilie Lothet, Tina Vrabec, Kevin Kilgore, Narendra Bhadra, Duco Jansen
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Publication number: 20160235969Abstract: Example adjustable electrodes are described. One example adjustable electrode includes two or more contacts configured to selectively deliver high frequency alternating current (HFAC) to a nerve in an amount sufficient to produce an HFAC nerve conduction block in the nerve. The example adjustable electrode may also include a logic configured to selectively control which of the two or more contacts deliver HFAC to the nerve to control whether the nerve electrode is in a first (e.g., onset response mitigating) configuration or in a second (e.g., HFAC nerve conduction block maintenance) configuration. The electrode may be used in applications including, but not limited to, nerve block applications, and nerve stimulation applications. The electrode may be adjusted by changing attributes including, but not limited to, the number, length, orientation, distance between, surface area, and distance from a nerve of contacts to be used to deliver the HFAC.Type: ApplicationFiled: April 29, 2016Publication date: August 18, 2016Inventors: Kevin Kilgore, Douglas Michael Ackermann, JR., Niloy Bhadra, Narendra Bhadra, Joe Payer
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Patent number: 9364661Abstract: Example adjustable electrodes are described. One example adjustable electrode includes two or more contacts configured to selectively deliver high frequency alternating current (HFAC) to a nerve in an amount sufficient to produce an HFAC nerve conduction block in the nerve. The example adjustable electrode may also include a logic configured to selectively control which of the two or more contacts deliver HFAC to the nerve to control whether the nerve electrode is in a first (e.g., onset response mitigating) configuration or in a second (e.g., HFAC nerve conduction block maintenance) configuration. The electrode may be used in applications including, but not limited to, nerve block applications, and nerve stimulation applications. The electrode may be adjusted by changing attributes including, but not limited to, the number, length, orientation, distance between, surface area, and distance from a nerve of contacts to be used to deliver the HFAC.Type: GrantFiled: August 20, 2014Date of Patent: June 14, 2016Assignee: Case Western Reserve UniversityInventors: Kevin Kilgore, Douglas Michael Ackermann, Jr., Niloy Bhadra, Narendra Bhadra, Joe Payer
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Patent number: 9008800Abstract: Example ionic coupling electrodes are described. One example ionic conducting electrode includes a first portion that can be coupled to a single phase current source. The first portion carries current flow via electrons. The electrode includes a second portion to apply a current to a nerve tissue. The second portion carries current flow via ions. The second portion is positioned between the nerve tissue and the first portion to prevent the first portion from touching the nerve tissue. The current applied to the nerve tissue is produced in the second portion in response to a current that is present in the first portion. The current present in the first portion is provided from a single phase current source. The electrode may be used in applications including, but not limited to, nerve block applications and nerve stimulation applications.Type: GrantFiled: November 18, 2010Date of Patent: April 14, 2015Assignee: Case Western Reserve UniversityInventors: Douglas Michael Ackermann, Jr., Kevin Kilgore, Niloy Bhadra, Narendra Bhadra
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Publication number: 20140358191Abstract: Example adjustable electrodes are described. One example adjustable electrode includes two or more contacts configured to selectively deliver high frequency alternating current (HFAC) to a nerve in an amount sufficient to produce an HFAC nerve conduction block in the nerve. The example adjustable electrode may also include a logic configured to selectively control which of the two or more contacts deliver HFAC to the nerve to control whether the nerve electrode is in a first (e.g., onset response mitigating) configuration or in a second (e.g., HFAC nerve conduction block maintenance) configuration. The electrode may be used in applications including, but not limited to, nerve block applications, and nerve stimulation applications. The electrode may be adjusted by changing attributes including, but not limited to, the number, length, orientation, distance between, surface area, and distance from a nerve of contacts to be used to deliver the HFAC.Type: ApplicationFiled: August 20, 2014Publication date: December 4, 2014Inventors: Kevin KILGORE, Douglas Michael ACKERMANN, JR., Niloy BHADRA, Narendra BHADRA, Joe PAYER
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Patent number: 8843188Abstract: Example adjustable electrodes are described. One example adjustable electrode includes two or more contacts configured to selectively deliver high frequency alternating current (HFAC) to a nerve in an amount sufficient to produce an HFAC nerve conduction block in the nerve. The example adjustable electrode also includes a logic configured to selectively control which of the two or more contacts deliver HFAC to the nerve to control whether the nerve electrode is in a first (e.g., onset response mitigating) configuration or in a second (e.g., HFAC nerve conduction block maintenance) configuration. The electrode may be used in applications including, but not limited to, nerve block applications, and nerve stimulation applications. The electrode may be adjusted by changing attributes including, but not limited to, the number, length, orientation, distance between, surface area, and distance from a nerve of contacts to be used to deliver the HFAC.Type: GrantFiled: November 18, 2010Date of Patent: September 23, 2014Assignee: Case Western Reserve UniversityInventors: Kevin Kilgore, Douglas Michael Ackermann, Jr., Niloy Bhadra, Narendra Bhadra, Joe Payer
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Publication number: 20130184787Abstract: A neural prosthesis includes a centralized device that can provide power, data, and clock signals to one or more individual neural prosthesis subsystems. Each subsystem may include a number of individually addressable, programmable modules that can be dynamically allocated or shared among neural prosthetic networks to achieve complex, coordinated functions or to operate in autonomous groups.Type: ApplicationFiled: July 16, 2012Publication date: July 18, 2013Inventors: Kevin Kilgore, Paul Hunter Packham, Timothy J. Crish, Brian Smith
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Patent number: 8060208Abstract: An example method for selectively and reversibly preventing the conduction of action potentials in a targeted nerve region is presented. The method includes generating an electrical waveform having two phases and selectively depolarizing a nerve membrane using the electrical waveform. The nerve membrane is depolarized to a state where the nerve membrane cannot conduct an action potential. The depolarization is achieved by selectively repetitively providing the electrical waveform to a targeted nerve region associated with the nerve region to control m gates and h gates in the region and thus to control the availability of ions.Type: GrantFiled: June 17, 2008Date of Patent: November 15, 2011Assignee: Case Western Reserve UniversityInventors: Kevin Kilgore, Niloy Bhadra
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Publication number: 20110160798Abstract: Example ionic coupling electrodes are described. One example ionic conducting electrode includes a first portion that can be coupled to a single phase current source. The first portion carries current flow via electrons. The electrode includes a second portion to apply a current to a nerve tissue. The second portion carries current flow via ions. The second portion is positioned between the nerve tissue and the first portion to prevent the first portion from touching the nerve tissue. The current applied to the nerve tissue is produced in the second portion in response to a current that is present in the first portion. The current present in the first portion is provided from a single phase current source. The electrode may be used in applications including, but not limited to, nerve block applications and nerve stimulation applications.Type: ApplicationFiled: November 18, 2010Publication date: June 30, 2011Applicant: CASE WESTERN RESERVE UNIVERSITYInventors: Douglas Michael ACKERMANN, JR., Kevin Kilgore, Niloy Bhadra, Narendra Bhadra
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Publication number: 20110125216Abstract: Example adjustable electrodes are described. One example adjustable electrode includes two or more contacts configured to selectively deliver high frequency alternating current (HFAC) to a nerve in an amount sufficient to produce an HFAC nerve conduction block in the nerve. The example adjustable electrode also includes a logic configured to selectively control which of the two or more contacts deliver HFAC to the nerve to control whether the nerve electrode is in a first (e.g., onset response mitigating) configuration or in a second (e.g., HFAC nerve conduction block maintenance) configuration. The electrode may be used in applications including, but not limited to, nerve block applications, and nerve stimulation applications. The electrode may be adjusted by changing attributes including, but not limited to, the number, length, orientation, distance between, surface area, and distance from a nerve of contacts to be used to deliver the HFAC.Type: ApplicationFiled: November 18, 2010Publication date: May 26, 2011Inventors: Kevin KILGORE, Douglas Michael Ackermann, JR., Niloy Bhadra, Narendra Bhadra, Joe Payer
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Publication number: 20080294221Abstract: An example method for selectively and reversibly preventing the conduction of action potentials in a targeted nerve region is presented. The method includes generating an electrical waveform having two phases and selectively depolarizing a nerve membrane using the electrical waveform. The nerve membrane is depolarized to a state where the nerve membrane cannot conduct an action potential. The depolarization is achieved by selectively repetitively providing the electrical waveform to a targeted nerve region associated with the nerve region to control m gates and h gates in the region and thus to control the availability of ions.Type: ApplicationFiled: June 17, 2008Publication date: November 27, 2008Applicant: CASE WESTERN RESERVE UNIVERSITYInventors: Kevin Kilgore, Niloy Bhadra