Abstract: A system and method for automatically digesting, culturing and growing a biopsy. The digester is a closed fluid transfer system, including disposable and durable parts, that receives a biopsy, washes the biopsy tissue, digests the tissue to separate the cells from each other, and seeds the cells in a culture flask. In one use, the system receives cells from a patient, expands and multiplies them, and returns them to the patient. A controller coordinates the motion of a plurality of pumps and the status of a plurality of valves, the pumps and the plurality of valves moving the fluid throughout the system. A sensor system assists the controller in volume and flow rate control of the fluids in the system, and in controlling the position of a tube providing air and fluids to a biopsy vial that includes the biopsy.

Abstract: Provided herein are compounds such as oligomers, peptide-oligomer-conjugates, and targeting sequences complementary to target regions within a pre-mRNA of the human uromodulin (UMOD) gene and pharmaceutical compositions thereof. Also provided herein are methods of treating a disease or disorder associated with aberrant expression of UMOD with the compounds and compositions thereof.

Abstract: A transistor includes a semiconductor substrate having a first terminal and a second terminal. An interconnect structure is formed on an upper surface of the semiconductor substrate, the interconnect structure being formed of multiple layers of dielectric material and electrically conductive material. The electrically conductive material of the interconnect structure includes a pillar in electrical contact with the first terminal, a first runner electrically connected to the pillar, a tap interconnect in electrical contact with the second terminal, a second runner electrically connected to the tap interconnect, a shield structure positioned between the pillar and the tap interconnect, and a shield runner electrically connected to the shield structure, the shield runner overlying the second runner in a direction perpendicular to the upper surface of the semiconductor substrate.

Abstract: A system and method for removable installation of a transparent display are disclosed. The system includes a transparent display that includes a transparent display panel with a front side and a back side, a cover glass or touch sensor coupled to the front side of the transparent display panel, and a transparency control medium coupled to the back side of the transparent display panel to provide transparency control of the transparent display panel. The transparent display panel can be a transparent organic lighting diode (TOLED) panel or a microLED panel. The transparency control medium can be an electrochromic (EC) glass, a Suspended Particle Device (SPD) film, or a Polymer Dispersed Liquid Crystal (PDLC) film. The system includes a versatile hinge assembly coupled to the TOLED display to enable the TOLED display to be used in a table top or desktop configuration or to be mounted to a support structure.

Abstract: Provided herein are oligonucleotides, peptide-oligonucleotide-conjugates, and a targeting sequence complementary to a target region within intron 1 of a pre-mRNA of human acid alpha-glucosidase (GAA) gene having at least one purine and pyrimidine-free abasic subunit. Also provided herein are methods of treating a muscle disease, a viral infection, or a bacterial infection in a subject in need thereof, comprising administering to the subject oligonucleotides, peptides, and peptide-oligonucleotide-conjugates described herein.

Abstract: A device includes a semiconductor substrate, a source metallization over an active area of the semiconductor substrate, a through-substrate via electrically connected to the source metallization, and an input bond pad formed in the semiconductor substrate and spaced apart from the active area. The input bond pad is electrically connected to a set of gate structures. The device includes a first inductive coil over the semiconductor substrate between a first portion of the source metallization and a second portion of the source metallization and a first capacitor over the semiconductor substrate between the first portion of the source metallization and the second portion of the source metallization. The first inductive coil and the first capacitor are connected in series between the input bond pad and the through-substrate via.

Abstract: A system and method for automatically digesting, culturing and growing a biopsy. The digester is a closed fluid transfer system, including disposable and durable parts, that receives a biopsy, washes the biopsy tissue, digests the tissue to separate the cells from each other, and seeds the cells in a culture flask. In one use, the system receives cells from a patient, expands and multiplies them, and returns them to the patient. A controller coordinates the motion of a plurality of pumps and the status of a plurality of valves, the pumps and the plurality of valves moving the fluid throughout the system. A sensor system assists the controller in volume and flow rate control of the fluids in the system, and in controlling the position of a tube providing air and fluids to a biopsy vial that includes the biopsy.

Abstract: A self-cleaning filtration media for use in hydrocarbon fluid filtration applications has a first layer on an upstream side and a second layer on a downstream side of the self-cleaning filtration media. The first layer is composed of polyethersulfone nanofibers having a diameter of 50-1000 nm (0.05-1 micron) and a basis weight of at least 1 gsm. The second layer is a nonwoven substrate suitable for filtration applications. The self-cleaning filtration media exhibits a dust holding capacity of at least 6 mg/cm2 and a filtration efficiency of greater than 90% for 4 micron particles when the self-cleaning filtration media is tested according to ISO 19438 for fuel filtration and according to ISO 4548-12 for oil filtration.

Abstract: Provided herein are antisense oligomers comprising a chemically modified antisense oligomer having a targeting sequence that is complementary to a target region of the human peripheral myelin protein 22 (PMP22) pre-mRNA. The antisense oligomer can be a peptide nucleic acid, a locked nucleic acid, phosphorodiamidate morpholino oligomer, a 2?-O-Me phosphorothioate oligomer, or a combination thereof. In an embodiment, the antisense oligomer is covalently linked to a cell-penetrating peptide. The antisense oligomers are useful for the treatment for various diseases in a subject in need thereof, including, but not limited to, a disease associated with dysregulation of peripheral myelin protein 22.

Abstract: A power converter can include first, second, third, and fourth power switches, and a driver for operating the drive switches to modify an input voltage. An AC coupling capacitor can be coupled between the first and fourth power switches. Bootstrap capacitors can be used for driving the first and second power switches, which can be high-side switches. In some embodiments, a current sensing circuit can be used to measure current through the third and/or fourth power switches and for determining the current through the power converter. In some embodiments, the power converter can monitor the voltage across the AC coupling capacitor and can determine the current through the power converter based on the monitored voltages. In some embodiments, the AC coupling capacitor can be pre-charged before the power converter begins normal operation.

Abstract: A self-cleaning filtration media for use in hydrocarbon fluid filtration applications has a first layer on an upstream side and a second layer on downstream side of the self-cleaning filtration media. The first layer is composed of polyethersulfone nanofibers having a diameter of 50-1000 nm (0.05-1 micron) and a basis weight of at least 1 gsm. The second layer is a nonwoven substrate suitable for filtration applications. The self-cleaning filtration media exhibits a dust holding capacity of at least 6 mg/cm2 and a filtration efficiency of greater than 90% for 4 micron particles when the self-cleaning filtration media is tested according to ISO 19438 for fuel filtration and according to ISO 4548-12 for oil filtration.

Abstract: A power amplifier device includes a transistor die with an elongated bondpad coupled to a terminal of an integrated transistor. The device also includes a substrate formed from a stack of alternating dielectric and patterned conductive layers. An elongated die contact is exposed at a first substrate surface and is attached to the elongated bondpad to provide a uniform connection between the die contact and the elongated bondpad. A vertical interconnect structure is connected to the die contact and extends towards the second substrate surface. A circuit includes passive component(s) coupled to the second substrate surface and to the vertical interconnect structure. An encapsulation material layer covers the passive component(s) and the second substrate surface. A plurality of device interconnects are coupled to the substrate, electrically coupled to the power transistor die, and exposed at a contact surface of the power amplifier device.

Abstract: The present invention relates to a combination roller blind wherein a fine adjustment means is provided behind an upper face of a headrail, the adjustment means causing an end of a blind sheet wrapped around a blind roll and an end opposite thereof to be fine-adjustably wrapped and unwrapped. When [the blind] is installed on a ceiling or a window frame to completely conceal the bottom edge of the window so that a bottom edge of a weight is adjoining a bottom sill of the window frame, and a portion of a light-transmissive section of the blind sheet is not overlapped, the opposite edge wrapped around the blind roll of the blind sheet can be fine-adjusted by rolling so that the light-transmissive section alternates with and is not completely overlapped by a light blocking section, allowing for complete shading to be achieved while completely concealing the bottom edge of the window.

Abstract: A power amplifier device includes a substrate, a power transistor die, and one or more surface mount components. The substrate has substrate die contacts exposed at a first substrate surface, and additional substrate contacts exposed at a second substrate surface. The power transistor die includes an integrated transistor. The transistor includes a control terminal and a first current conducting terminal coupled, respectively, to first and second die contacts at the first die surface, and a second current conducting terminal coupled to a third die contact at a second die surface. The surface-mount components are connected to the additional substrate components, and the surface-mount components are electrically coupled through the substrate to the first and second die contacts. The power amplifier device also includes an encapsulation material layer covering the surface-mount components and the second substrate surface.

Abstract: A power amplifier device includes a substrate formed from a stack of alternating dielectric and patterned conductive layers and conductive vias electrically connecting the patterned conductive layers. The substrate has a set of substrate die contacts exposed at a first substrate surface, and an air cavity extending into the substrate through a portion of the first substrate surface that is located between the set of substrate die contacts. A power transistor die has first and second die contacts at a first die surface, which are connected to the substrate die contacts. The power transistor die also includes an integrated transistor in an active area of the die. The integrated transistor includes a control terminal coupled to the first die contact, and a first current conducting terminal coupled to the second die contact. The active area is aligned with the first air cavity.

Abstract: A power amplifier device includes first and second power transistor dies and a substrate. Each die includes an elongated bondpad and an integrated transistor with a terminal that is coupled to the elongated bondpad. The substrate is formed from a stack of multiple dielectric layers and multiple patterned conductive layers in an alternating arrangement, and a plurality of conductive vias electrically coupling portions of the conductive layers. The substrate includes elongated first and second die contacts exposed at a first substrate surface and connected to the first and second elongated bondpads, respectively. The substrate also includes a conductive structure connected between the first and second die contacts. The conductive structure is formed from portions of the patterned conductive layers and at least two vias of the plurality of conductive vias.

Abstract: A power converter can include first, second, third, and fourth power switches, and a driver for operating the drive switches to modify an input voltage. An AC coupling capacitor can be coupled between the first and fourth power switches. Bootstrap capacitors can be used for driving the first and second power switches, which can be high-side switches. In some embodiments, a current sensing circuit can be used to measure current through the third and/or fourth power switches and for determining the current through the power converter. In some embodiments, the power converter can monitor the voltage across the AC coupling capacitor and can determine the current through the power converter based on the monitored voltages. In some embodiments, the AC coupling capacitor can be pre-charged before the power converter begins normal operation.

Abstract: An amplifier module includes a module substrate with a mounting surface, a signal conducting layer, a ground layer, and a ground terminal pad at the mounting surface. A thermal dissipation structure extends through the module substrate. A ground contact of a power transistor die is coupled to a surface of the thermal dissipation structure. Encapsulant material covers the mounting surface of the module substrate and the power transistor die, and a surface of the encapsulant material defines a contact surface of the amplifier module. A ground terminal is embedded within the encapsulant material. The ground terminal has a proximal end coupled to the ground terminal pad, and a distal end exposed at the contact surface. The ground terminal is electrically coupled to the ground contact of the power transistor die through the ground terminal pad, the ground layer of the module substrate, and the thermal dissipation structure.

Abstract: An RF amplifier includes at least one harmonic trap filter with an array of shunt filter legs having a non-uniform resonance frequency distribution. The harmonic trap filter is configured to suppress frequencies in a suppression frequency range that includes harmonic frequencies of carrier frequencies in a range of carrier frequencies. Each of the shunt filter legs includes a capacitor and inductor coupled in series, and an intermediate node coupled between the capacitor and the inductor. Each intermediate node of the shunt filter leg is coupled to at least one other intermediate node of another shunt filter leg of the filter with a dampening resistor. Shunt filters at or near edges of the array are configured to have lower resonance frequencies than those at or near the center of the array to suppress excess current flow at edges of the RF amplifier.

Abstract: A transistor includes a source contact connected to a Through-Silicon Via (TSV). A drain contact is connected to a first pad. A gate structure is interposed between the source contact and the drain contact. A second pad is connected to the gate structure, the second pad comprising a first side diametrically opposed to a second side, and a third side interposed therebetween, the source contact proximal to the third side, a first portion of the first side and a second portion of the second side.