Abstract: The present invention provides novel antigen binding peptides, such as an antibody or antibody fragment, that specifically bind to selective FXIa inhibitors and/or dual inhibitors of FXIa, and plasma kallikrein. The present invention further relates to methods of reducing the antithrombotic effect of FXIa inhibitors by administering to a subject a pharmaceutically effective dose of the antigen binding peptides provided herein. In addition, the present invention provides detection reagents and methods for detecting the level of the inhibitors of FXIa in a biological sample.

Abstract: The present invention provides novel antigen binding peptides, such as an antibody or antibody fragment, that specifically bind to selective FXIa inhibitors and/or dual inhibitors of FXIa, and plasma kallikrein. The present invention further relates to methods of reducing the antithrombotic effect of FXIa inhibitors by administering to a subject a pharmaceutically effective dose of the antigen binding peptides provided herein. In addition, the present invention provides detection reagents and methods for detecting the level of the inhibitors of FXIa in a biological sample.

Abstract: A thermoplastic pipe gasket fabricated of a thermoset material is provided having a first pipe engaging surface and an exterior surface, with the exterior surface having applied thereto a water-based, flexible, slip-coating. The slip-coating comprises polyurethane, a cross-linking agent, and a dispersion of a friction reducing compound. The friction reducing compound can be selected from a fluoropolymer, silicone, or graphite, either alone or in combinations thereof. Depending on the method of fabrication, the slip-coating can be sprayed onto the thermoset material after the thermoset material has been extruded, but before the extrudate's fabrication into a gasket. Alternatively, the slip-coating can be sprayed onto the gasket following its assembly. Still further, the slip-coating can be applied to the thermoset material by dipping the thermoset material into the water-based, flexible, slip-coating.

Abstract: A corrugated pipe saddle gasket is provided having a leading member, a primary sealing member, and an arm member, with the gasket having a contoured surface extending along at least a portion of the bottom of the primary sealing member and the arm member corresponding to the shape of a corrugated pipe. The primary sealing member of a second length is intermediate the leading member of a first length and the arm member of a third length, with the third length being greater than the sum of the first and second lengths. The gasket has at least a portion of its arm member having a durometer different from the durometer of the primary sealing member. In the preferred embodiment, the arm member has an axis that is substantially horizontal, and the leading member has an axis that is substantially vertical, such that the two axes are substantially perpendicular.

Abstract: The present invention provides isolated modified inosine 5′-monophosphate dehydrogenase (IMPDH) polypeptides. These modified IMPDH polypeptides comprise a substitute oligo-peptide that replaces the subdomain region. The modified polypeptides of the invention bind to an inhibitor, such as MPA, and/or exhibit functional activity of wild-type IMPDH holo-enzyme.