Patents by Inventor Kevin Kunnen

Kevin Kunnen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of producing cancer targeting compounds
    Patent number: 9845283
    Abstract: Provided herein are methods of making the compound of Formula I: and certain intermediates involved in such process.
    Type: Grant
    Filed: August 9, 2016
    Date of Patent: December 19, 2017
    Assignee: INSPYR THERAPEUTICS, INC.
    Inventors: John K Lynch, Jeff Hutchison, Xiong Fu, Kevin Kunnen
  • Methods of producing cancer treating compounds
    Patent number: 9822064
    Abstract: Provided herein are methods of making the compound of Formula I: and certain intermediates involved in such process.
    Type: Grant
    Filed: August 9, 2016
    Date of Patent: November 21, 2017
    Assignee: Inspyr Therapeutics, Inc.
    Inventors: John K Lynch, Jeff Hutchison, Xiong Fu, Kevin Kunnen
  • Methods of Producing Cancer Compounds
    Publication number: 20160347706
    Abstract: Provided herein are methods of making the compound of Formula I: and certain intermediates involved in such process.
    Type: Application
    Filed: August 9, 2016
    Publication date: December 1, 2016
    Applicant: Genspera, Inc.
    Inventors: John K. Lynch, Jeff Hutchison, Xiong Fu, Kevin Kunnen
  • Methods of Producing Cancer Compounds
    Publication number: 20160347730
    Abstract: Provided herein are methods of making the compound of Formula I: and certain intermediates involved in such process.
    Type: Application
    Filed: August 9, 2016
    Publication date: December 1, 2016
    Applicant: Genspera, Inc.
    Inventors: John K. Lynch, Jeff Hutchison, Xiong Fu, Kevin Kunnen
  • Methods of producing cancer compounds
    Patent number: 9446141
    Abstract: Provided herein are methods of making the compound of Formula I: and certain intermediates involved in such process.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: September 20, 2016
    Assignee: GenSpera, Inc.
    Inventors: John K Lynch, Jeff Hutchison, Xiong Fu, Kevin Kunnen
  • Methods of Producing Cancer Compounds
    Publication number: 20160030589
    Abstract: Provided is a method for making the compound of Formula 1: Various compounds utilized in that method are also provided, as are methods of making those compounds. Also provided is a compound having the formula XO—CO—(CH2)nNH2, where n is an integer greater than 2. A method of making that compound is additionally provided. Further provided is a method of making a prodrug of a bioactive compound.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 4, 2016
    Applicant: Genspera, Inc.
    Inventors: John K Lynch, Jeff Hutchison, Xiong Fu, Kevin Kunnen
  • Exemestane and its intermediates and methods of making the same
    Patent number: 8541609
    Abstract: A method is provided for preparing an aromatase inhibitor of formula (I) wherein each of R1, R2, R3, R4, independently, is hydrogen, halogen or C1-C6 alkyl. In one form, the aromatase inhibitor is exemestane wherein each of R1, R2, R3, R4 is hydrogen. In the method, a compound of formula (II) wherein R1, R2, R3, R4 are as defined above and R is alkylene, is reacted with a deprotonating agent and a compound of the formula R5SO2X wherein R5 is C1-C5 alkyl and X is halogen so as to obtain a compound of formula (III) wherein R1, R2, R3, R4, R5 are as defined above. The compound of Formula (III) is then reacted with a base to form an aromatase inhibitor of formula (I).
    Type: Grant
    Filed: April 19, 2012
    Date of Patent: September 24, 2013
    Assignee: Cedarburg Pharmaceuticals, Inc.
    Inventors: Kevin Kunnen, Nathan W. Stehle, Scot W. Weis, John M. Pascone, Richard J. Pariza, Scott G. Van Ornum, Paul Zizelman
  • Exemestane and its Intermediates and Methods of Making the Same
    Publication number: 20120209016
    Abstract: A method is provided for preparing an aromatase inhibitor of formula (I) wherein each of R1, R2, R3, R4, independently, is hydrogen, halogen or C1-C6 alkyl. In one form, the aromatase inhibitor is exemestane wherein each of R1, R2, R3, R4 is hydrogen. In the method, a compound of formula (II) wherein R1, R2, R3, R4 are as defined above and R is alkylene, is reacted with a deprotonating agent and a compound of the formula R5SO2X wherein R5 is C1-C5 alkyl and X is halogen so as to obtain a compound of formula (III) wherein R1, R2, R3, R4, R5 are as defined above. The compound of Formula (III) is then reacted with a base to form an aromatase inhibitor of formula (I).
    Type: Application
    Filed: April 19, 2012
    Publication date: August 16, 2012
    Inventors: Kevin Kunnen, Nathan W. Stehle, Scot W. Weis, John M. Pascone, Richard J. Pariza, Scott G. Van Ornum, Paul Zizelman
  • Exemestane and its intermediates and methods of making the same
    Patent number: 8183401
    Abstract: A method is provided for preparing an aromatase inhibitor of formula (I) wherein each of R1, R2, R3, R4, independently, is hydrogen, halogen or C1-C6 alkyl. In one form, the aromatase inhibitor is exemestane wherein each of R1, R2, R3, R4 is hydrogen. In the method, a compound of formula (II) wherein R1, R2, R3, R4 are as defined above and R is alkylene, is reacted with a deprotonating agent and a compound of the formula R5SO2X wherein R5 is C1-C5 alkyl and X is halogen so as to obtain a compound of formula (III) wherein R1, R2, R3, R4, R5 are as defined above. The compound of Formula (III) is then reacted with a base to form an aromatase inhibitor of formula (I).
    Type: Grant
    Filed: January 14, 2005
    Date of Patent: May 22, 2012
    Assignee: Cedarburg Pharmaceuticals, Inc.
    Inventors: Kevin Kunnen, Nathan W. Stehle, Scot W. Weis, John M. Pascone, Richard J Pariza, Scott G. Van Ornum, Paul Zizelman
  • Exemestane and Its Intermediates and Methods of Making the Same
    Publication number: 20080234505
    Abstract: A method is provided for preparing an aromatase inhibitor of formula (I) wherein each of R1, R2, R3, R4, independently, is hydrogen, halogen or C1-C6 alkyl. In one form, the aromatase inhibitor is exemestane wherein each of R1, R2, R3, R4 is hydrogen. In the method, a compound of formula (II) wherein R1, R2, R3, R4 are as defined above and R is alkylene, is reacted with a deprotonating agent and a compound of the formula R5SO2X wherein R5 is C1-C5 alkyl and X is halogen so as to obtain a compound of formula (III) wherein R1, R2, R3, R4, R5 are as defined above. The compound of Formula (III) is then reacted with a base to form an aromatase inhibitor of formula (I).
    Type: Application
    Filed: January 14, 2005
    Publication date: September 25, 2008
    Applicant: CEDARBURG PHARMACEUTICALS, INC
    Inventors: Kevin Kunnen, Nathan W. Stehle, Scot W. Weis, John M. Pascone, Richard J. Pariza, Scott G. Van Ornum, Paul Zizelman
  • Aqueous method to prepare cyclopropyl methylketone from acetyl-propanol
    Patent number: 6025528
    Abstract: An entirely aqueous method to prepare cyclopropyl methylketone from acetyl-propanol. The method is practiced by (1) forming a mixture of acetyl-propanol and an aqueous hydrogen halide, (2) distilling the mixture and returning at least a portion of the distillate that is aqueous to the distilland, (3) recovering 5-halo-2-pentanone from the distillate, and (4) reacting the 5-halo-2-pentanone with a basic solution that is from about 1-wt % to about 25-wt % base and about 75-wt % to about 99-wt % water to yield cyclopropyl methylketone.
    Type: Grant
    Filed: March 3, 1998
    Date of Patent: February 15, 2000
    Assignee: Great Lakes Chemical Corporation
    Inventors: Kevin Kunnen, Ignacio H. Sanchez