Abstract: The subject invention provides a robust, quantitative, and reproducible process and assay for diagnosis of a neurological condition in a subject. The invention provides measurement of two or more biomarkers in a biological fluid such as CSF or serum resulting in a synergistic mechanism for determining the extent of neurological damage in a subject with an abnormal neurological condition and for discerning subtypes thereof or tissue types subjected to damage.

Abstract: Various aspects of the present invention are directed to apparatuses, systems, and methods that may include a tissue ablation system. The tissue ablation system may include an ablation device; an ablation generator; and a controller configured to cause the ablation generator to apply a first power level to the ablation device and cause the ablation generator to apply a second power level to the ablation device, the second power level being higher than the first power level; the power provided by the ablation generator to the ablation device is adjusted from the first power level to the second power level, adjusting the power from the first power level to the second power level includes causing the ablation generator to provide a plurality of distinct intermediate power levels corresponding to delivering a plurality of intermediate energy levels from the ablation device, and each of the intermediate power levels is between the first power level and the second power level.