Abstract: The present invention provides methods for the treatment of non-alcoholic steatohepatitis (NASH) including advanced fibrotic and/or cirrhotic stages of NASH. The methods include administration of a compound comprising a double stranded RNAi (dsRNAi) oligonucleotide, or a pharmaceutically acceptable salt thereof, to the patient. The dsRNAi oligonucleotide optionally contains an antisense strand and a sense strand, wherein the antisense strand and the sense strand form a duplex region, and wherein the antisense strand comprises a region of complementarity to a KHK mRNA target sequence.

Abstract: dsRNAi oligonucleotides can be used in methods for the treatment of NASH, preferably the advanced fibrotic and/or cirrhotic stages thereof, using dosage regimens comprising a loading phase followed by a maintenance phase.

Abstract: A method for forming a thermoplastic body having regions with varied material composition and/or porosity. Powder blends comprising a thermoplastic polymer, a sacrificial porogen and an inorganic reinforcement or filler are molded to form complementary parts with closely toleranced mating surfaces. The parts are formed discretely, assembled and compression molded to provide a unitary article that is free from discernible boundaries between the assembled parts. Each part in the assembly has differences in composition and/or porosity, and the assembly has accurate physical features throughout the sections of the formed article, without distortion and nonuniformities caused by variable compaction and densification rates in methods that involve compression molding powder blends in a single step.

Abstract: A method for forming a thermoplastic body having regions with varied material composition and/or porosity. Powder blends comprising a thermoplastic polymer, a sacrificial porogen and an inorganic reinforcement or filler are molded to form complementary parts with closely toleranced mating surfaces. The parts are formed discretely, assembled and compression molded to provide a unitary article that is free from discernible boundaries between the assembled parts. Each part in the assembly has differences in composition and/or porosity, and the assembly has accurate physical features throughout the sections of the formed article, without distortion and nonuniformities caused by variable compaction and densification rates in methods that involve compression molding powder blends in a single step.

Abstract: A method for forming a thermoplastic body having regions with varied material composition and/or porosity. Powder blends comprising a thermoplastic polymer, a sacrificial porogen and an inorganic reinforcement or filler are molded to form complementary parts with closely toleranced mating surfaces. The parts are formed discretely, assembled and compression molded to provide a unitary article that is free from discernible boundaries between the assembled parts. Each part in the assembly has differences in composition and/or porosity, and the assembly has accurate physical features throughout the sections of the formed article, without distortion and nonuniformities caused by variable compaction and densification rates in methods that involve compression molding powder blends in a single step.

Abstract: A method and apparatus for inspecting transparent materials. An optical inspection apparatus comprises a prism, a mirror, and a light source. The prism has a first end, a first side, and a second side. The first side is opposite the second side, the first end is located between the first side and the second side, the first end has an angled surface, and the prism is capable of bending light. The first side is around parallel to the second side. The mirror is on the angled surface. The mirror is capable of redirecting light entering the prism on the first side along a directed line of sight to the second side along a line of sight to a viewer. The light source is attached to another surface on the first end. The light source is capable of transmitting light through the prism along the directed line of sight.

Abstract: A method and apparatus for inspecting transparent materials. An optical inspection apparatus comprises a prism, a mirror, and a light source. The prism has a first end, a first side, and a second side. The first side is opposite the second side, the first end is located between the first side and the second side, the first end has an angled surface, and the prism is capable of bending light. The first side is around parallel to the second side. The mirror is on the angled surface. The mirror is capable of redirecting light entering the prism on the first side along a directed line of sight to the second side along a line of sight to a viewer. The light source is attached to another surface on the first end. The light source is capable of transmitting light through the prism along the directed line of sight.