Abstract: Guidewire-management devices and systems. The guidewire-management device can include a guidewire, a first sleeve, and a second sleeve. The first sleeve can be configured for distally feeding the guidewire out of the guidewire-management device. The first sleeve can also be configured for proximally feeding the guidewire into the guidewire-management device. The second sleeve can be proximal of the first sleeve in the guidewire-management device. The second sleeve can be configured for feeding the guidewire in concert with the first sleeve. At least a length of the guidewire extending between the first sleeve and the second sleeve can be disposed within a sterile barrier configured to maintain sterility of the guidewire.

Abstract: A personal display device for displaying virtual images to a wearer including a frame having a right temple section, a left temple section, a right eye see-through section, and a left eye see-through section; a projection display device connected to the frame; a processor connected to the projection display device and arranged within the left temple section or right temple section; and at least one waveguide stack module connected to the frame, the at least one waveguide stack module being configured to receive image-bearing light beams from the projection display device.

Abstract: The present disclosure provides novel 15-hydroxy-prostaglandin dehydrogenase inhibitors, pharmaceutical compositions comprising such compounds, and methods of using such compounds and compositions in treating 15-hydroxy-prostaglandin dehydrogenase-mediated disease. Also provided are methods of making such compounds and intermediates thereof. The compounds have a general Formula (A). Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (A).

Abstract: A personal display device for displaying virtual images to a wearer including a frame having a right temple section, a left temple section, a right eye see-through section, and a left eye see-through section; a projection display device connected to the frame; a processor connected to the projection display device and arranged within the left temple section or right temple section; and at least one waveguide stack module connected to the frame, the at least one waveguide stack module being configured to receive image-bearing light beams from the projection display device.

Abstract: A device orientation calibration system to perform operations that include: accessing inertial measurement unit (IMU) data generated by an IMU mounted upon an object that corresponds with a first reference frame, the IMU data indicating a second reference frame that comprises a Z-axis, a Y-axis, and an X-axis; performing a calibration of the IMU data to align the second reference frame of the IMU with the first reference frame of the object, the performing the calibration comprising: determining a gravitational vector based on a first portion of the IMU data; applying a first rotation to the IMU data to align the Z-axis of the second reference frame with the gravitational vector; determining a forward motion vector based on a second portion of the IMU data; and applying a second rotation to the IMU data to align the X-axis of the second reference frame with the forward motion vector.

Abstract: Guidewire-management devices and systems thereof are disclosed herein. A guidewire-management device can include a guidewire, a first sleeve, and a second sleeve. The first sleeve can be configured for distally feeding the guidewire out of the guidewire-management device. The first sleeve can also be configured for proximally feeding the guidewire into the guidewire-management device. The second sleeve can be proximal of the first sleeve in the guidewire-management device. The second sleeve can be configured for feeding the guidewire in concert with the first sleeve. At least a length of the guidewire extending between the first sleeve and the second sleeve can be disposed within a sterile barrier configured to maintain sterility of the guidewire.

Abstract: One variation of a method includes: detecting a set of radio signals transmitted between a set of computing devices and a set of access points in the space; for each radio signal in the set of radio signals, extracting a pair of unique identifiers representing an initial computing device and an initial access point from the radio signal; storing the pair of unique identifiers in a set of containers; accessing a known position of the wireless sensor; accessing a signal transmission range of an access point based on the set of containers; deriving a signal strength of a radio signal based on the known position and the signal transmission range; in response to the signal strength exceeding a threshold signal strength, deriving a location unit occupied by the access point; and aggregating the location unit into a localization map representing locations of the set of access points in the space.

Abstract: Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.

Abstract: A systems for detecting level sensor malfunction or tampering based on reductant consumption and determining when to initiate a quality check of reductant used in an aftertreatment system are disclosed. The system comprises a memory storing instructions and a processor executing the instructions to perform a process including: receiving dosing data associated with an amount of DEF supplied to the aftertreatment system; receiving tank level data from a level sensor in a DEF tank; comparing the dosing data with the tank level data; and based on the comparison: initiating, by the one or more processors, a quality check; and/or determining, by the one or more processors, a possible error requiring further diagnostics; and causing to present, by the one or more processors, an indication that the quality check is being initiated and/or that a possible error requires further diagnostics on a display.

Abstract: A personal display device for displaying virtual images to a wearer. The personal display device includes a frame having a right temple section, a left temple section, a right rear section, a left rear section, a right eye see-through section, and a left eye see-through section; a projection display device connected to the frame for projecting an image to the wearer; at least one waveguide stack module connected to the frame for propagating image-bearing light beams along a length of the at least one waveguide stack module, the at least one waveguide stack module being configured to receive the image from the projection display device and detected touch motions of the wearer sensed by the touchpad including sensing directions of the touch motions of the wearer.

Abstract: A systems for detecting level sensor malfunction or tampering based on reductant consumption and determining when to initiate a quality check of reductant used in an aftertreatment system are disclosed. The system comprises a memory storing instructions and a processor executing the instructions to perform a process including: receiving dosing data associated with an amount of DEF supplied to the aftertreatment system; receiving tank level data from a level sensor in a DEF tank; comparing the dosing data with the tank level data; and based on the comparison: initiating, by the one or more processors, a quality check; and/or determining, by the one or more processors, a possible error requiring further diagnostics; and causing to present, by the one or more processors, an indication that the quality check is being initiated and/or that a possible error requires further diagnostics on a display.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable media for configuration of optical sensor devices in vehicles based on thermal data. To manage the temperature of an optical sensor device, temperature data describing the current temperature of the optical sensor is used to determine whether the current temperature meets or exceeds a predetermined threshold temperature. If the current temperature meets or exceeds the threshold temperature, the optical sensor device may be configured into a modified operating mode to reduce the current temperature of the optical sensor device. For example, the operating mode of the optical sensor device may be modified to terminate one or more processes, reduce a frame rate at which image/video data is captured, and the like.

Abstract: The present invention provides a platform providing curated entertainment options and event suggestions based on preference data associated with a user profile and/or feedback provided regarding the entertainment options and event suggestions. The platform is configured to receive feedback regarding pandemic compliance measures (e.g., COVID-19 safety protocols) and/or disability accommodations provided by the one or more venues and/or events. The platform includes an artificial intelligence module, which analyzes the feedback regarding pandemic compliance measures and/or disability accommodations in order to generate custom-catered suggestions for each user profile.

Abstract: Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.

Abstract: An engine valve actuation system includes engine braking rocker arms each having a hydraulically actuated switch, and an electrohydraulic control system including an actuation fluid supply, an electrically actuated valve adjustable to vary a pressure of actuation fluid supplied from the actuation fluid supply to the hydraulically actuated switches, and an engine braking control unit. The engine braking control unit is structured to command adjusting the electrically actuated valve to adjust the hydraulically actuated switch in each of the engine braking rocker arms at a switching window timing that is varied from engine braking cycle to engine braking cycle to distribute hard handoffs among the engine braking rocker arms.

Abstract: A reduction device includes a housing defining an input chamber configured to receive exhaust from a power source, an output chamber, an exhaust channel configured to direct the exhaust from the input chamber to the output chamber, and a longitudinal axis. The reduction device also includes a treatment unit disposed in the exhaust channel and along the longitudinal axis. The treatment unit is configured to at least partly remove pollutant species from the exhaust. The reduction device also includes an attenuation component disposed in the housing and radially outward of the treatment unit. The attenuation component is fluidly connected to the exhaust channel, and is configured to attenuate a range of frequencies corresponding to operation of the power source. Additionally, the exhaust channel prohibits exhaust entering the input chamber from exiting the housing without passing through the treatment unit.

Abstract: A reduction device includes a housing defining an input chamber configured to receive exhaust from a power source, an output chamber, an exhaust channel configured to direct the exhaust from the input chamber to the output chamber, and a longitudinal axis. The reduction device also includes a treatment unit disposed in the exhaust channel and along the longitudinal axis. The treatment unit is configured to at least partly remove pollutant species from the exhaust. The reduction device also includes an attenuation component disposed in the housing and radially outward of the treatment unit. The attenuation component is fluidly connected to the exhaust channel, and is configured to attenuate a range of frequencies corresponding to operation of the power source. Additionally, the exhaust channel prohibits exhaust entering the input chamber from exiting the housing without passing through the treatment unit.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable media for configuration of optical sensor devices in vehicles based on thermal data. To manage the temperature of an optical sensor device, temperature data describing the current temperature of the optical sensor is used to determine whether the current temperature meets or exceeds a predetermined threshold temperature. If the current temperature meets or exceeds the threshold temperature, the optical sensor device may be configured into a modified operating mode to reduce the current temperature of the optical sensor device. For example, the operating mode of the optical sensor device may be modified to terminate one or more processes, reduce a frame rate at which image/video data is captured, and the like.

Abstract: An exhaust system includes an exhaust pressure sensing system having sensor conduits structured to fluidly connect to an exhaust conduit in an exhaust system and feed exhaust to a differential pressure sensor. The differential pressure sensor produces a pressure signal indicative of a pressure drop across an exhaust aftertreatment element such as an exhaust filter. A plugging-mitigation conduit provides an always-open leakage path to convey condensate in a stream of leaked exhaust between the sensor conduits to prevent formation of deposits that can impact pressure sensing accuracy.

Abstract: An engine optimization controller may determine values of a set of input parameters of an engine and process, using an engine model, the values to determine a plurality of sets of potential output parameters. The engine optimization controller may determine, based on the plurality of sets of potential output parameters, an engine optimization scheme, which may indicate a first number of cylinders, of one or more cylinders of the engine, to be active and to receive gas; a second number of cylinders, of the one or more cylinders, to be inactive and to receive gas, and/or a third number of cylinders, of the one or more cylinders, to be inactive and to not receive gas. The engine optimization controller may provide the engine configuration scheme to another controller to allow control of the one or more cylinders and one or more fuel injectors according to the engine configuration scheme.