Patents by Inventor Kevin M. Brady

Kevin M. Brady has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Variants of plasminogen activators and processes for their production
    Patent number: 5520911
    Abstract: A fibrinolytically active amino acid sequence variant of a plasminogen activator is prepared that has one or more glycosylation sites in regions that are not glycosylated in the native molecule. DNA sequences can be prepared that encode the variants, as well as expression vectors incorporating the DNA sequences, and host cells transformed with the expression vectors. The variants may be used in a pharmaceutical preparation to treat a vascular disease or condition in patients.
    Type: Grant
    Filed: December 13, 1994
    Date of Patent: May 28, 1996
    Assignee: Genentech, Inc.
    Inventors: Stephen Anderson, Kevin M. Brady, Bruce A. Keyt, Leonard G. Presta
  • Variants of tissue plasminogen activator, compositions and methods of use for same
    Patent number: 5385732
    Abstract: A fibrinolytically active amino acid sequence variant of a plasminogen activator is prepared that has one or more glycosylation sites in regions that are not glycosylated in the native molecule. DNA sequences can be prepared that encode the variants, as well as expression vectors incorporating the DNA sequences, and host cells transformed with the expression vectors. The variants may be used in a pharmaceutical preparation to treat a vascular disease or condition in patients.
    Type: Grant
    Filed: March 22, 1993
    Date of Patent: January 31, 1995
    Assignee: Genentech, Inc.
    Inventors: Stephen Anderson, Kevin M. Brady, Bruce A. Keyt, Leonard G. Presta
  • DNA encoding variants of tissue plasminogen activators and expression vectors and hosts thereof
    Patent number: 5346824
    Abstract: A fibrinolytically active amino acid sequence variant of a plasminogen activator is prepared that has one or more glycosylation sites in regions that are not glycosylated in the native molecule. DNA sequences can be prepared that encode the variants, as well as expression vectors incorporating the DNA sequences, and host cells transformed with the expression vectors. The variants may be used in a pharmaceutical preparation to treat a vascular disease or condition in patients.
    Type: Grant
    Filed: March 22, 1993
    Date of Patent: September 13, 1994
    Assignee: Genentech, Inc.
    Inventors: Stephen Anderson, Kevin M. Brady, Bruce A. Keyt, Leonard G. Presta
  • DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
    Patent number: 5270198
    Abstract: A fibrinolytically active amino acid sequence variant of a plasminogen activator is prepared that has one or more glycosylation sites in regions that are not glycosylated in the native molecule. DNA sequences can be prepared that encode the variants, as well as expression vectors incorporating the DNA sequences, and host cells transformed with the expression vectors. The variants may be used in a pharmaceutical preparation to treat a vascular disease or condition in patients.
    Type: Grant
    Filed: January 21, 1992
    Date of Patent: December 14, 1993
    Assignee: Genentech, Inc.
    Inventors: Stephen Anderson, Kevin M. Brady, Bruce A. Keyt, Leonard G. Presta