Abstract: A powered handle for a surgical stapler can have a drive system including an electric motor. The powered handle can include a manual articulation mechanism to articulate a jaw assembly coupled to a reload shaft connected to the handle. The manual articulation mechanism can include a ball screw mechanism that translates an articulation member responsive to rotation of an articulation knob when an instrument shaft is engaged with the handle. The articulation mechanism includes a release function that allows the jaw assembly to return to a longitudinally centered orientation. The powered handle includes a battery pack serving as a power supply for the drive system. A control system can control actuation of the motor based on user inputs and operating parameters of the stapler and can provide certain motor drive profiles for predetermined positions of the stapler. The powered handle can include a manual return mechanism.

Abstract: Disclosed are ROS-sensitive NOS inhibitors, as well as methods of making and using the same.

Abstract: Disclosed are ROS-sensitive NOS inhibitors, as well as methods of making and using the same.

Abstract: A truck bed extender having a pair of generally parallel, spaced apart side walls which are joined to a back wall, and having an open top and an open bottom. A pair of forward pointing plates or tabs are coupled to the side walls, with the forward pointing plates generally structured and configured to slidably engage slots defined by the strike plates and truck bed walls of a pickup truck. A pair of downward pointing plates or tabs, each including an opening for a latch bolt, are also coupled to the side walls, with the downward pointing plates structured and configured to slidably engage the slots defined by the latch plates and sides of the tail ate of a pickup truck.