Patents by Inventor Kevin M. Pawlik

Kevin M. Pawlik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polycistronic Vector for Human Induced Pluripotent Stem Cell Production
    Publication number: 20160076000
    Abstract: Methods of producing induced pluripotent stem (iPS) cells are provided. For example, a method of producing an iPS cell from a differentiated cell, which includes transforming the differentiated cell with a first vector comprising a nucleic acid sequence comprising a nucleic acid sequence encoding an Oct4, a nucleic acid sequence encoding a Sox2, and a nucleic acid sequence encoding a Klf4. Each of the nucleic acid sequences are separated from each other by a first and second viral 2A sequence. The method described can further comprise culturing the transformed cell under conditions that allow for the production of an iPS cell and isolating the cultured iPS cell.
    Type: Application
    Filed: September 29, 2015
    Publication date: March 17, 2016
    Inventors: Tim Townes, Kevin M. Pawlik
  • Polycistronic vector for human induced pluripotent stem cell production
    Patent number: 9175311
    Abstract: Methods of producing induced pluripotent stem (iPS) cells are provided. For example, a method of producing an iPS cell from a differentiated cell, which includes transforming the differentiated cell with a first vector comprising a nucleic acid sequence comprising a nucleic acid sequence encoding an Oct4, a nucleic acid sequence encoding a Sox2, and a nucleic acid sequence encoding a Klf4. Each of the nucleic acid sequences are separated from each other by a first and second viral 2A sequence. The method described can further comprise culturing the transformed cell under conditions that allow for the production of an iPS cell and isolating the cultured iPS cell.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: November 3, 2015
    Assignee: The UAB Research Foundation
    Inventors: Tim Townes, Kevin M. Pawlik
  • Polycistronic Vector for Human Induced Pluripotent Stem Cell Production
    Publication number: 20130017596
    Abstract: Methods of producing induced pluripotent stem (iPS) cells are provided. For example, a method of producing an iPS cell from a differentiated cell, which includes transforming the differentiated cell with a first vector comprising a nucleic acid sequence comprising a nucleic acid sequence encoding an Oct4, a nucleic acid sequence encoding a Sox2, and a nucleic acid sequence encoding a Klf4. Each of the nucleic acid sequences are separated from each other by a first and second viral 2A sequence. The method described can further comprise culturing the transformed cell under conditions that allow for the production of an iPS cell and isolating the cultured iPS cell.
    Type: Application
    Filed: May 25, 2012
    Publication date: January 17, 2013
    Applicant: THE UAB RESEARCH FOUNDATION
    Inventors: TIM TOWNES, KEVIN M. PAWLIK
  • Polycistronic Vector For Human Induced Pluripotent Stem Cell Production
    Publication number: 20100150889
    Abstract: Methods of producing induced pluripotent stem (iPS) cells are provided. For example, a method of producing an iPS cell from a differentiated cell, which includes transforming the differentiated cell with a first vector comprising a nucleic acid sequence comprising a nucleic acid sequence encoding an Oct4, a nucleic acid sequence encoding a Sox2, and a nucleic acid sequence encoding a Klf4. Each of the nucleic acid sequences are separated from each other by a first and second viral 2A sequence. The method described can further comprise culturing the transformed cell under conditions that allow for the production of an iPS cell and isolating the cultured iPS cell.
    Type: Application
    Filed: December 17, 2009
    Publication date: June 17, 2010
    Applicant: THE UAB RESEARCH FOUNDATION
    Inventors: Tim Townes, Kevin M. Pawlik