Abstract: In some examples, a neuromodulation catheter includes a neuromodulation element convertible between a low-profile delivery state and a radially expanded deployed state, the neuromodulation element including: an elongated structure configured to have a substantially linear shape defining a longitudinal axis when the neuromodulation element is in the low-profile delivery state, and further configured to have a coiled shape defining a coiled outer surface when the neuromodulation element is in the radially expanded deployed state; one or more electrodes spaced longitudinally apart along the longitudinal axis of the elongated structure; and one or more wires coupled to respective electrodes of one or more electrodes at respective coupling points, wherein the coupling points are arranged such that, when the neuromodulation element is in the deployed state, the coupling points are oriented along the coiled outer surface of the elongated structure.

Abstract: Support devices and associated systems and methods for releasably retaining a delivery system handle while delivering a medical device to a target within a human are described herein. The support device is configured to engage the delivery system handle and enable a user to maneuver a distal end portion of the delivery system by manipulating features of the support device.

Abstract: Aspects of the disclosure generally relate to systems and methods for transcatheter delivery of an implant, such as a prosthetic heart valve, to a target site. Such systems can include a delivery system and an implant having a brim secured to an anchoring member. Systems and methods of the disclosure can include everting the brim of the prosthetic heart valve so that the everted brim and a capsule of the delivery system collectively sheathe the anchoring member of the prosthetic heart valve during delivery of the prosthetic heart valve to the target site.

Abstract: A telescoping catheter including an elongated tubular member having a proximal end, a distal end, and a passageway extending between the proximal end and the distal end. The tubular member includes a first tubular segment and a second tubular segment. The first tubular segment and the second tubular segment are slidable relative to one another to vary a length of the tubular member. The first tubular segment includes a first connector mateable with a second connector of the second tubular segment to selectively maintain the first and second tubular segments in an extended position. The second tubular segment includes a second proximal end that is mateable with a handle.

Abstract: A system includes a prosthesis and a delivery system for delivery thereof. The prosthesis includes a self-expanding frame and a plurality of attachment tabs extending from a first end of the frame. The delivery system includes a shaft, a piston disposed over the shaft, and a capsule which is movable relative to the piston. The piston includes an annular groove or a plurality of circumferentially-extending grooves on an outer surface thereof. In a delivery configuration of the delivery system, the plurality of attachment tabs are disposed within the annular groove of the piston, or the plurality of circumferentially-extending grooves of the piston, and the capsule covers and constrains the prosthesis in a radially collapsed configuration, with the capsule extending over the annular groove, or the plurality of circumferentially-extending grooves, of the piston and the attachment tabs received therein.

Abstract: Support devices and associated systems and methods for releasably retaining a delivery system handle while delivering a medical device to a target within a human are described herein. The support device is configured to engage the delivery system handle and enable a user to maneuver a distal end portion of the delivery system by manipulating features of the support device.

Abstract: A catheter may include an elongate body comprising a proximal portion and a distal portion, and a plurality of electrodes carried by the distal portion. The distal portion of the catheter may be configured to transform from a low-profile delivery state to a radially expanded deployed state in which at least some electrodes of ‘the plurality of electrodes are deployed at different circumferential positions of the radially expanded deployed slate. A ratio of a deployed electrode length to a diameter of the distal portion of the catheter in the radially expanded deployed state may be less than or equal to about 2.0. The deployed electrode length is a distance between, in the radially expanded deployed, stole, a proximal-most point of a proximal-most electrode of the plurality of electrodes and a distal-most point of a distal-most electrode of the plurality of electrodes.

Abstract: Methods, systems, devices, assemblies and apparatuses for renal denervation. The system includes a guide catheter. The guide catheter has a lumen and a guide catheter energy delivery element. The distal portion of the guide catheter is configured to be intravascularly positioned within a main vessel. The system include an inner catheter. The inner catheter is positioned within the lumen of the guide catheter and has multiple energy delivery elements. The multiple energy delivery elements include a first energy delivery element and a second energy delivery element. The system includes a controller. The controller is coupled to the renal denervation device. The controller is configured to measure a first impedance between the first energy delivery element and the guide catheter energy delivery element. The controller is configured to provide a location of the inner catheter within the renal blood vessel based on the first impedance.

Abstract: Systems for delivering prosthetic heart valve devices can include, for example, an elongated catheter body, a deliver capsule carried by the catheter body, and an expandable atraumatic member. The delivery capsule includes a platform and a housing having an outer wall and a proximal rim, and the platform is configured to be releasably coupled to a prosthetic heart valve device. The housing is configured to slide along the platform from a containment configuration to a deployment configuration. The expandable atraumatic member has an atraumatic surface and a peripheral portion. The atraumatic member has a compacted configuration and an expanded configuration in which the peripheral portion extends laterally outward over the proximal rim of the housing to protect tissue of the heart and the vasculature from potentially being damaged by the proximal rim of the housing as the delivery system is withdrawn in a proximal direction through the patient.

Abstract: Delivery systems with telescoping capsules for delivering prosthetic heart valve devices and associated methods are disclosed herein. A delivery system configured in accordance with embodiments of the present technology can include, for example, a delivery capsule having a first housing, a second housing slidably disposed within a portion of the first housing, and a prosthetic device constrained within the first and second housings. During deployment, the first housing is moved in a first direction over the second housing, thereby releasing a first portion of the prosthetic device. Subsequently, fluid the second housing is moved in the first direction to release a second portion of the prosthetic device.

Abstract: Delivery systems with telescoping capsules for delivering prosthetic heart valve devices and associated methods are disclosed herein. A delivery system configured in accordance with embodiments of the present technology can include, for example, a delivery capsule having a first housing, a second housing slidably disposed within a portion of the first housing, and a prosthetic device constrained within the first and second housings. The delivery capsule can further include first and second chamber defined in part by the first and second housings. During deployment, fluid is delivered to the first chamber to move the first housing distally over the second housing, thereby releasing a portion of the prosthetic device. Subsequently, fluid is delivered to the second chamber such that the first and second housings move together in the distal direction to release a second portion of the prosthetic device.

Abstract: A delivery system for prosthetic heart valves are provided. The delivery system includes a flexible shaft, a distal sheath capsule configured to contain the prosthetic heart valve, an inner steerable catheter including an inner distal flex component, and an outer steerable catheter including an outer distal flex component. The inner distal flex component includes a first cut pattern and a second cut pattern distal to the first cut pattern. The outer distal flex component includes a third cut pattern. The inner steerable catheter is rotatable at least 90 degrees relative to the outer steerable catheter when the third cut pattern of the outer distal flex component is disposed over at least a portion of the first cut pattern of the inner distal flex component and each of the inner steerable catheter and the outer steerable catheter is in the flexed configuration.

Abstract: The present disclosure relates to numerous devices and methods for transcatheter stented prosthetic heart valve loading and delivery. Such devices and methods reduce suture tangling and also provide the ability to adjust the stented prosthetic heart valve expansion and contraction prior to the final release of the stented prosthetic heart valve from the delivery device.

Abstract: Systems for delivering prosthetic heart valve devices can include, for example, an elongated catheter body, a deliver capsule carried by the catheter body, and an expandable atraumatic member. The delivery capsule includes a platform and a housing having an outer wall and a proximal rim, and the platform is configured to be releasably coupled to a prosthetic heart valve device. The housing is configured to slide along the platform from a containment configuration to a deployment configuration. The expandable atraumatic member has an atraumatic surface and a peripheral portion. The atraumatic member has a compacted configuration and an expanded configuration in which the peripheral portion extends laterally outward over the proximal rim of the housing to protect tissue of the heart and the vasculature from potentially being damaged by the proximal rim of the housing as the delivery system is withdrawn in a proximal direction through the patient.

Abstract: A telescoping catheter including an elongated tubular member having a proximal end, a distal end, and a passageway extending between the proximal end and the distal end. The tubular member includes a first tubular segment and a second tubular segment. The first tubular segment and the second tubular segment are slidable relative to one another to vary a length of the tubular member. The first tubular segment includes a first connector mateable with a second connector of the second tubular segment to selectively maintain the first and second tubular segments in an extended position. The second tubular segment includes a second proximal end that is mateable with a handle.

Abstract: A telescoping catheter including an elongated tubular member having a proximal end, a distal end, and a passageway extending between the proximal end and the distal end. The tubular member includes a first tubular segment and a second tubular segment. The first tubular segment and the second tubular segment are slidable relative to one another to vary a length of the tubular member. The first tubular segment includes a first connector mateable with a second connector of the second tubular segment to selectively maintain the first and second tubular segments in an extended position. The second tubular segment includes a second proximal end that is mateable with a handle.

Abstract: Support devices and associated systems and methods for releasably retaining a delivery system handle while delivering a medical device to a target within a human are described herein. The support device is configured to engage the delivery system handle and enable a user to maneuver a distal end portion of the delivery system by manipulating features of the support device.

Abstract: Systems for delivering prosthetic heart valve devices can include, for example, an elongated catheter body, a deliver capsule carried by the catheter body, and an expandable atraumatic member. The delivery capsule includes a platform and a housing having an outer wall and a proximal rim, and the platform is configured to be releasably coupled to a prosthetic heart valve device. The housing is configured to slide along the platform from a containment configuration to a deployment configuration. The expandable atraumatic member has an atraumatic surface and a peripheral portion. The atraumatic member has a compacted configuration and an expanded configuration in which the peripheral portion extends laterally outward over the proximal rim of the housing to protect tissue of the heart and the vasculature from potentially being damaged by the proximal rim of the housing as the delivery system is withdrawn in a proximal direction through the patient.

Abstract: Delivery systems with telescoping capsules for delivering prosthetic heart valve devices and associated methods are disclosed herein. A delivery system configured in accordance with embodiments of the present technology can include, for example, a delivery capsule having a first housing, a second housing slidably disposed within a portion of the first housing, and a prosthetic device constrained within the first and second housings. The delivery capsule can further include first and second chamber defined in part by the first and second housings. During deployment, fluid is delivered to the first chamber to move the first housing distally over the second housing, thereby releasing a portion of the prosthetic device. Subsequently, fluid is delivered to the second chamber such that the first and second housings move together in the distal direction to release a second portion of the prosthetic device.

Abstract: Delivery systems with telescoping capsules for delivering prosthetic heart valve devices and associated methods are disclosed herein. A delivery system configured in accordance with embodiments of the present technology can include, for example, a delivery capsule having a first housing, a second housing slidably disposed within a portion of the first housing, and a prosthetic device constrained within the first and second housings. The delivery capsule can further include first and second chamber defined in part by the first and second housings. During deployment, fluid is delivered to the first chamber to move the first housing distally over the second housing, thereby releasing a portion of the prosthetic device. Subsequently, fluid is delivered to the second chamber such that the first and second housings move together in the distal direction to release a second portion of the prosthetic device.