Abstract: In one aspect, the disclosure relates to substituted N-(2-(2,6-dioxopiperidinyl-3-yl)-1,3-dioxoisoindolin-5-yl)arylsulfonamide analogs that useful as modulators of cereblon (CRBN) activity, methods of making same, pharmaceutical compositions comprising same, and methods of treating various clinical conditions and disorders using same, e.g., a disorder of uncontrolled cellular proliferation, such as a cancer, which may be associated with cereblon protein dysfunction and/or a GSPT1 dysfunction. In various further aspects, the disclosed compounds can selectively modulate the degradation of GSPT1 protein, i.e., the disclosed compounds can act as GSPT1 degraders. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: In one aspect, the disclosure relates to substituted N-(2-(2,6-dioxopiperidinyl-3-yl)-1,3-dioxoisoindolin-5-ypaiylsulfo namide analogs that useful as modulators of cereblon (CRBN) activity, methods of making same, pharmaceutical compositions comprising same, and methods of treating various clinical conditions and disorders using same, e.g., a disorder of uncontrolled cellular proliferation, such as a cancer, which may be associated with cereblon protein dysfunction and/or a GSPT1 dysfunction. In various further aspects, the disclosed compounds can selectively modulate the degradation of GSPT1 protein, i.e., the disclosed compounds can act as GSPT1 degraders. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: Furniture systems, such as desks, that can be stand-alone wall mounted, wall mounted with furniture positioned in front, or attached/mounted to furniture, and that also accommodate differing types of computers or electronics and wires in an efficient and visually appealing manner. Specifically, the furniture includes a concealment pocket which provides that cabling and associated structures can be hidden above the floor.

Abstract: Television mounting devices that can be stand-alone wall mounted, wall mounted with furniture positioned in front, or attached/mounted to furniture, and that also accommodate differing types of television or other electronics and wires in an efficient and visually appealing manner.

Abstract: Television mounting devices that can be stand-alone wall mounted, wall mounted with furniture positioned in front, or attached/mounted to furniture, and that also accommodate differing types of television or other electronics and wires in an efficient and visually appealing manner.

Abstract: Television mounting devices that can be stand-alone wall mounted, wall mounted with furniture positioned in front, or attached/mounted to furniture, and that also accommodate differing types of television or other electronics and wires in an efficient and visually appealing manner.

Abstract: Television mounting devices that can be stand-alone wall mounted, wall mounted with furniture positioned in front, or attached/mounted to furniture, and that also accommodate differing types of television or other electronics and wires in an efficient and visually appealing manner.

Abstract: Furniture systems, such as desks, that can be stand-alone wall mounted, wall mounted with furniture positioned in front, or attached/mounted to furniture, and that also accommodate differing types of computers or electronics and wires in an efficient and visually appealing manner. Specifically, the furniture includes a concealment pocket which provides that cabling and associated structures can be hidden above the floor.

Abstract: This disclosure relates to pieces of furniture for housing electronic devices and that give the appearance of being permanently built into a wall. The pieces of furniture comprise panels which can easily be removed and which house and hide wires of electronic devices, giving the appearance that the wires are housed beyond the wall. Additionally, the pieces of furniture are designed to have electronic devices mounted thereon with little mounting (i.e., studs are unnecessary) or no mounting to secure the piece of furniture onto the wall.

Abstract: Television mounting devices that can be stand-alone wall mounted, wall mounted with furniture positioned in front, or attached/mounted to furniture, and that also accommodate differing types of television or other electronics and wires in an efficient and visually appealing manner.

Abstract: This disclosure relates to pieces of furniture for housing electronic devices and that give the appearance of being permanently built into a wall. The pieces of furniture comprise panels which can easily be removed and which house and hide wires of electronic devices, giving the appearance that the wires are housed beyond the wall. Additionally, the pieces of furniture are designed to have electronic devices mounted thereon with little mounting (i.e., studs are unnecessary) or no mounting to secure the piece of furniture onto the wall.

Abstract: Genes and variant RNAs that are differentially expressed in human colon tumor tissues compared with normal colon tissue and the corresponding proteins are identified. These genes and the corresponding antigens are suitable targets for the treatment, diagnosis or prophylaxis of colon cancer.

Abstract: An expandable stand is provided to accommodate televisions of different sizes. The expandable stand includes a fixed frame to support the television, shelves for electronic components or other items, an expandable top, and a rear panel which may include a box to hide electrical wires and cables.

Abstract: Assembling a generic system for testing a network-based telephony system. The process begins by abstracting required performance characteristics of a network-based telephony system. For each functional element of abstracted characteristics, the system separates generic characteristics from implementation-specific performance characteristics of the network; the system proceeds by constructing test components addressing each functional element;, and then it assembles the test components into a unified set, including enabling configuration of each template to accommodate specific network implementations.

Abstract: A process of implementing a test plan for an IP-based telephony network. The process consists initially of installing a system test module as an integral component of the network-based system, whereby test procedures originate within the network-based system, employing system resources rather than outside components to accomplish testing. Further steps are assembling a set of generic functional tests, each test including the components of test elements, each element addressing a single system action, together with verification for completion of such action; test legs, each leg encompassing the actions of a single actor in the test and including interactions between such actors; and a test activity, setting out a single function to be accomplished by the test and combining the functions of one or more test legs, including the interactions among the same.

Abstract: Genes that are upregulated in human prostate tumor tissues and the corresponding proteins are identified. These genes and the corresponding antigens are suitable targets for the treatment, diagnosis or prophylaxis of prostate cancer.

Abstract: A system (and methods) for monitoring telecommunications services end-to-end through a distributed network environment. The system includes a distributed telecommunication network, which is capable of providing communications to a plurality of users during an active state. The system also has a plurality of point of presence servers distributed throughout the cities served by the distributed telecommunication network. Each of the point of presence servers is adapted to provide a test pattern from a plurality of test patterns where each of the test patterns correspond respectively to one of a plurality of services. The test pattern is transferred from one of the point of presence servers to another point of presence server to identify a quality level of the distributed telecommunication network between the one point of presence server and the other point of presence server. Other features are also included.

Abstract: A biosensor for detecting and measuring analytes in an aqueous solution. The biosensor device has a sensor design based on modeling of the active-site chemistry of reactive molecules such as enzymes, antibodies and cellular receptors. The sensor design takes advantage of a synthetic polymer modeled after these reactive molecules to provide reversible, sensitive and reliable detection of analytes in the form of a versatile and economical device.