Publication number: 20090209522
Abstract: A compound of formula (I): wherein either B is absent and A and Z are the same or different and are each hydrogen, halogen, alkyl, hydroxy, alkoxy, —CN, —C(Rc)2OH, —N(Rd)C(?X)Rc, —C(?X)N(Rc)(Rd), —S(O)m—Rc, —N(Rc)(Rd)S(O)2, —S(O)2N(Rc)(Rd), —N(Rc)2, aryl optionally substituted with Ra or —O-aryl optionally substituted with Ra; or B is present and is —(CH2)n—, —C(Rb)2— or —O—, or B taken together with A or Z can be —C?C(Rb)—, —C(Rb)?C—, —CH2—CH(Rb)— or —CH(Rb)—CH2—; D is —O— or —S(O)m?—; E is a bond or is —(CH2)n—, —N(Rd)—, —(CH2)nN(Rd)— or —N(Rd)(CH2)n—; F is —C(?X)—; G is —(CH2)n—, —N(Rd)—, —(CH2)nN(Rd)— or —N(Rd)(CH2)n; J is a bond, —O—, —N(RC)C(?X)—, —C(?X)N(Rc)—, —S(O)m?—, —N(Rc)S(O)m—, —S(O)nN(Rc)—, —N(Rc)— or —N(Rg)(Rh); K is a bond, alkylene, cycloalkylene, cycloalkenylene, arylene, heterocycloalkylene, heterocycloalkylene or heteroarylene; and L is hydrogen or a terminal group; has therapeutic utility.
Type:
Application
Filed:
June 27, 2006
Publication date:
August 20, 2009
Inventors:
Graham Andrew Showell, David John Miller, Angela Glen, Maria Angeles Cubillo De Dios, Kevin Merchant, Ajay Kumar Mandal
