Abstract: Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter d1 of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Ti that is less than or equal to 0.85*s1, wherein s1 is a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

Abstract: Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter d1 of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Ti that is less than or equal to 0.85*s1, wherein s1 is a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

Abstract: A system, comprising one or more processors; and memory storing instructions executable by the one or more processors to causes the system to associate together streams of data from at least three devices separated by a network, the at least three devices comprising a first device of a first user, a second device of the first user, and a third device of a second user, wherein association of the streams of data together enables the first device to receive data from the third device and the third device to receive data from the first device and the second device, wherein the data from the first device and the second device indicate playing of a first musical instrument by the first user and the data from the third device indicates playing of a second musical instrument by the second user, update a first user interface of the first device according to an event that occurred on the third device, and update a second user interface of the third device according to an event that occurred on the third device.

Abstract: A piano training device is described herein. The piano training device comprising a plurality of keys which may be illuminated by a light source associated with each key. The light source associated with each key is oriented such that the light source transmits light toward the front surface of the key. The key is further manufactured so that the light transmitted toward the front surface of the key is redirected to the top surface of the key.

Abstract: A piano training device is described herein. The piano training device comprising a plurality of keys which may be illuminated by a light source associated with each key. The light source associated with each key is oriented such that the light source transmits light toward the front surface of the key. The key is further manufactured so that the light transmitted toward the front surface of the key is redirected to the top surface of the key.

Abstract: A piano training device is described herein. The piano training device comprising a plurality of keys which may be illuminated by a light source associated with each key. The light source associated with each key is oriented such that the light source transmits light toward the front surface of the key. The key is further manufactured so that the light transmitted toward the front surface of the key is redirected to the top surface of the key.

Abstract: A piano training device is described herein. The piano training device comprising a plurality of keys which may be illuminated by a light source associated with each key. The light source associated with each key is oriented such that the light source transmits light toward the front surface of the key. The key is further manufactured so that the light transmitted toward the front surface of the key is redirected to the top surface of the key.

Abstract: The present invention provides methods of identifying a clonal population of cells suitable for large-scale production of a protein of interest. The invention further provides methods for high-throughput screening for genetic rearrangements in the gene encoding the protein of interest, whereby the absence of a deletion in the gene encoding the protein of interest indicates that the cell is suitable for large-scale production of the protein of interest.

Abstract: The present invention is based on the discovery that the transcriptional activity of both hamster mammary tumor 7 (HMT-7) and hamster layilin genes are increased when Chinese Hamster Ovary (CHO) cells are cultured at temperatures lower than 37° C. The present invention provides novel genomic, cDNA, and protein sequences of HMT-7 and a novel genomic sequence for hamster layilin. Included in the genomic sequences are novel temperature-induced promoter sequences for each; two promoter sequences are provided for HMT-7 and one promoter sequence is provided for layilin. The invention additionally provides antisense and siRNA molecules to the nucleic acid molecules of HMT-7. The invention also provides genetically engineered expression vectors comprising the novel temperature-induced promoters of the invention, which are particularly useful as part of a mammalian temperature-inducible expression system.

Abstract: A system including at least one computer configured as a server that contains a database of deal information, business rules, libraries and templates for deals for at least one business entity is provided. The system further includes at least one client system connected to the server through a network. The server is configured to prompt a user to create a deal, including identifying deal team members, notify members of the deal team of tasks to perform and milestones accomplished, receive documents relating to a deal from a client system that are submitted for approval by a user, and provide access to the deal documents through a client system for review and approval.

Abstract: A system including at least one computer configured as a server that contains a database of deal information, business rules, libraries and templates for deals for at least one business entity is provided. The system further includes at least one client system connected to the server through a network. The server is configured to prompt a user to create a deal, including identifying deal team members, notify members of the deal team of tasks to perform and milestones accomplished, receive documents relating to a deal from a client system that are submitted for approval by a user, and provide access to the deal documents through a client system for review and approval.

Abstract: A system including at least one computer configured as a server that contains a database of deal information, business rules, libraries and templates for deals for at least one business entity is provided. The system further includes at least one client system connected to the server through a network. The server is configured to prompt a user to create a deal, including identifying deal team members, notify members of the deal team of tasks to perform and milestones accomplished, receive documents relating to a deal from a client system that are submitted for approval by a user, and transmit the deal documents to a client system for review and approval.