Abstract: Novel salicylamine derivatives are targeted directly to the mitochondria to increase effectiveness and lower required dosages in the treatment of conditions caused by inflammation or oxidative stress.

Abstract: Novel salicylamine derivatives are targeted directly to the mitochondria to increase effectiveness and lower required dosages in the treatment of conditions caused by inflammation or oxidative stress.

Abstract: A health monitoring device, comprising: processing circuitry configured to generate a test monitor signal, the test monitor signal configured to imitate a monitor signal of interest; transmission circuitry configured to transmit the test monitor signal over the signal path to a host device, the test monitor signal for determining at the host device an integrity of the signal path for transmission of the monitor signal of interest over the signal path.

Abstract: One embodiment of a modular device for removal, storage, and installation of removable components of a convertible vehicle according to the present disclosure comprises a wheeled base, a vertical support structure, and a horizontal support component, and a connector plate. The vertical support structure may attach to the wheeled base in a “stored” or “deployed” position. Similarly, the horizontal support component may attach to the wheeled base in a “stored” position or to the vertical support structure in a “deployed” position. Another embodiment of a modular device further comprises a plurality of support rods and storage rods. The support and storage rods may attach to the wheeled base in a “stored” or “deployed” position. One embodiment of a system according to the present disclosure comprises a device for removing, storing, and installing removable components from convertible automobiles that is configured to connect to a mechanical lifting device.

Abstract: A ladder rack assembly with a first rack member, a second rack member, and a threaded bolt. The first rack member has a first bracket and a first crossbar coupled to the first bracket, and the second rack member has a second bracket and a second crossbar coupled to the second bracket. The first crossbar and the second crossbar are slidably coupled to each other. The threaded bolt extends through the first crossbar and the second crossbar and is threadedly coupled to a nut. When the threaded bolt is rotated in a clockwise direction, the nut moves along the threaded bolt in a first direction, and when the threaded bolt is rotated in a counterclockwise direction, the nut moves along the threaded bolt in a second direction. The first bracket, the second bracket, and the threaded bolt are configured to retain an object during transport.

Abstract: A ladder rack assembly with a first rack member, a second rack member, and a threaded bolt. The first rack member has a first bracket and a first crossbar coupled to the first bracket, and the second rack member has a second bracket and a second crossbar coupled to the second bracket. The first crossbar and the second crossbar are slidably coupled to each other. The threaded bolt extends through the first crossbar and the second crossbar and is threadedly coupled to a nut. When the threaded bolt is rotated in a clockwise direction, the nut moves along the threaded bolt in a first direction, and when the threaded bolt is rotated in a counterclockwise direction, the nut moves along the threaded bolt in a second direction. The first bracket, the second bracket, and the threaded bolt are configured to retain an object during transport.

Abstract: The transcoding of a contribution feed into a plurality of output feeds in various formats can be monitored to ensure that unnecessary data is not transmitted in the contribution feed. Each output feed can be transcoded using respective values for a set of video format parameters. These values can be aggregated and analyzed to determine the lowest values for individual parameters that are being used for the various output feeds. A video encoder for the contribution feed can then dynamically modify the video format parameters used to encode the contribution feed in order to avoid encoding and transmitting data that is not actually used for these output streams, which can conserve resources such as network bandwidth, or enable those resources to be used more advantageously to send data that will actually result in higher quality video presentation in the output formats for current limitations or conditions.

Abstract: The present invention is directed to a modified clostridial neurotoxin comprising a botulinum neurotoxin A (BoNT/A) Hcc domain, wherein the Hcc domain comprises a modification of methionine 1144 (MI 144), and wherein the modification increases oxidative resistance of the modified clostridial neurotoxin when compared to an otherwise identical clostridial neurotoxin lacking the modification. Also provided are (inter alia) corresponding methods for producing the same, methods for selecting oxidation resistant clostridial neurotoxins, nucleic acids encoding the same, and therapeutic uses of said modified clostridial neurotoxins.

Abstract: The present invention relates to a method for proteolytically processing a single-chain clostridial neurotoxin into a corresponding di-chain clostridial neurotoxin, the method comprising: providing a single-chain clostridial neurotoxin; and contacting the single-chain clostridial neurotoxin with furin; wherein the single-chain clostridial neurotoxin has an activation loop comprising or consisting of the polypeptide sequence Arg-Xaa-Xaa-Arg; and wherein furin hydrolyses a peptide bond of the activation loop thereby producing a di-chain clostridial neurotoxin. The invention also relates to engineered clostridial neurotoxins and methods for manufacturing the same, as well as related pharmaceutical compositions, nucleotide sequences, and therapeutic and cosmetic uses.

Abstract: A chair includes first support comprising a passageway, a second support, a body of material extending from the first support to the second support, a rod extending between the first support and the second support, and a threaded nut. The rod includes a main body and a threaded portion sized to be received by the passageway. The threaded nut is configured to be positioned about and to interface with the threaded portion. Rotating the rod clockwise causes the main body to move laterally away from the support.

Abstract: Techniques for on-demand issuance of private keys for encrypted video transmission are described. A video processing service of a provider network receives a request from a computing device outside the provider network to begin video processing of video data generated by a video source device outside the provider network. The video processing service sends instructions to a video encoding device associated with the video source device to establish the connection for video transmission. The video processing service sends an encryption key to the video encoding device, and sends a decryption key to a video decryption engine. Subsequently, the video processing service receives video data from the video source device, via the video encoding device.

Abstract: The transcoding of a contribution feed into a plurality of output feeds in various formats can be monitored to ensure that unnecessary data is not transmitted in the contribution feed. Each output feed can be transcoded using respective values for a set of video format parameters. These values can be aggregated and analyzed to determine the lowest values for individual parameters that are being used for the various output feeds. A video encoder for the contribution feed can then dynamically modify the video format parameters used to encode the contribution feed in order to avoid encoding and transmitting data that is not actually used for these output streams, which can conserve resources such as network bandwidth, or enable those resources to be used more advantageously to send data that will actually result in higher quality video presentation in the output formats for current limitations or conditions.

Abstract: A contribution encoder receives media from a source, encodes the media, and transmits the encoded media to a network-adaptive encoding system for eventual distribution to end users. The network-adaptive encoding system tests a network connection between the contribution encoder and the network-adaptive encoding system before transmission of the encoded media begins. The network-adaptive encoding system uses the results of the test to select appropriate values for parameters that define the encoding and transmission of the media. The selected parameter values are transmitted by the network-adaptive encoding system to the contribution encoder for use in encoding and transmitting the media.

Abstract: The transcoding of a contribution feed into a plurality of output feeds in various formats can be monitored to ensure that unnecessary data is not transmitted in the contribution feed. Each output feed can be transcoded using respective values for a set of video format parameters. These values can be aggregated and analyzed to determine the lowest values for individual parameters that are being used for the various output feeds. A video encoder for the contribution feed can then dynamically modify the video format parameters used to encode the contribution feed in order to avoid encoding and transmitting data that is not actually used for these output streams, which can conserve resources such as network bandwidth, or enable those resources to be used more advantageously to send data that will actually result in higher quality video presentation in the output formats for current limitations or conditions.

Abstract: A system and method for management of bandwidth shared by a plurality of video content encoders is provided. A management service coordinates an unequal allocation of available bandwidth among a set of encoding nodes. The management service can receive measured bandwidth attributes from a plurality of encoding nodes to determine a total available bandwidth. The management service can then allocate the available bandwidth based by applying allocation criteria that can include performance criteria, financial criteria or other prioritization criteria. The management service can then transmit the allocated bandwidth to the encoding nodes.

Abstract: A system and method for management of bandwidth shared by a plurality of video content encoders is provided. A management service coordinates an unequal allocation of available bandwidth among a set of encoding nodes. A management service can receive measured bandwidth attributes from a plurality of encoding nodes to determine a total available bandwidth. The management service can receive measured bandwidth attributes from a plurality of encoding nodes that is transmitted to the management service in accordance with an IoT based messaging protocol. The management service can then allocate the available bandwidth based on different criteria. The management service can then transmit the allocated bandwidth to the encoding nodes using the IoT based messaging protocol.

Abstract: Techniques for adapting source ports for traffic include generating a first packet with a header and a payload, the header including an indication of a first source port from which the first packet is to be transmitted. The first packet is transmitted to a receiver using the first source port and, upon not receiving an acknowledgment from the receiver, a second packet with second header and the same payload is generated. The second header includes an indication of a second, different source port from which the second packet is to be transmitted. The second packet is transmitted to the receiver using the second, different source port. An acknowledgment is received from the receiver for one of the first or second packets, and the acknowledgment includes an indication of the source port that sent the packet.

Abstract: Techniques for on-demand issuance of private keys for encrypted video transmission are described. A video processing service of a provider network receives a request from a computing device outside the provider network to begin video processing of video data generated by a video source device outside the provider network. The video processing service sends instructions to a video encoding device associated with the video source device to establish the connection for video transmission. The video processing service sends an encryption key to the video encoding device, and sends a decryption key to a video decryption engine. Subsequently, the video processing service receives video data from the video source device, via the video encoding device.

Abstract: Methods and systems are provided to determine suitable hyperparameters for a machine learning model and/or feature engineering process. A suitable machine learning model and associated hyperparameters are determined by analyzing a dataset. Suitable hyperparameter values for compatible machine learning models having one or more hyperparameters in common and a compatible dataset schema are identified. Hyperparameters may be ranked according to each of their respective influences on a model performance metrics, and hyperparameter values identified as having greater influence may be more aggressively searched.

Abstract: Techniques are described enabling users to transfer the association of a cloud-managed video encoding or decoding device from one region of a cloud provider network to another. A video processing service of a cloud provider network enables users to purchase video encoding or decoding devices that can be used to encode and reliably transfer video content to the video processing service from locations of the users' choice. The video processing service receives a request to transfer the association of a video encoding or decoding device from one region of the cloud provider to another and the video processing service executes workflows that enable the association of a video encoding or decoding device to be transferred to one region from another.