Abstract: An I. S. Machine has a plurality of sections each of which has a controller located with the blank side operator interface which receives a sync signal from a machine control and data from a machine data server. The controller operates the section in accordance with a number of cycles commanded by an operator via blank and blow side interfaces.

Abstract: Compounds that selectively inhibit the binding of ligands to ?4?1 integrin (VLA-4) and methods for their preparation are disclosed. In one embodiment, compounds of the invention are represented by Formula I: As selective inhibitors of VLA-4 mediated cell adhesion, compounds of the present invention are useful in the treatment of conditions associated with such adhesion, including, but not limited to, such conditions as inflammatory and autoimmune responses, diabetes, asthma, psoriasis, inflammatory bowel disease, transplantation rejection, and tumor metastasis. Also disclosed are methods of inhibiting VLA-4 mediated cell adhesion and methods of treating conditions associated with LA-4 mediated cell adhesion.

Abstract: A delivery system for use in minimally invasive surgery that is made up of a substantially cylindrical hollow sleeve and a hooked deployment rod adapted to slide within the hollow sleeve is provided. The inventive delivery system serves to protect and pass anastomotic devices such as self-closing surgical devices (e.g., self-closing surgical clip assemblies) through laparoscopic and thoracoscopic parts. The subject invention also provides a method for protecting and passing such anastomotic devices through laparoscopic and thoracoscopic parts and for precisely delivering these devices to operating or surgical sites.

Abstract: N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I: Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-? expression utilizing compounds of the present invention are also disclosed.

Abstract: Disclosed are substituted benzimidazole compounds of formula (I): wherein R1, R2, R3, R4 and Xa are defined herein. The compounds of the invention inhibit Itk kinase and are therefore useful for treating diseases and pathological conditions involving inflammation, immunological disorders and allergic disorders. Also disclosed are processes for preparing these compounds and to pharmaceutical compositions comprising these compounds.

Abstract: Disclosed are ketone substituted benzimidazole compounds of formula(I): wherein R1, R2, R3, R4 and Xa are defined herein. The compounds of the invention inhibit Itk kinase and are therefore useful for treating diseases and pathological conditions involving inflammation, immunological disorders and allergic disorders. Also disclosed are processes for preparing these compounds and to pharmaceutical compositions comprising these compounds.

Abstract: This invention is directed to physiologically active compounds of formula (I) wherein represents a bicyclic ring system, of about 10 to about 13 ring members, in which the ring is an azaheterocycle, and the ring represents an azaheteroaryl ring, or an optionally halo substituted benzene ring; R1 represents hydrogen or a straight- or branched-chain alkyl group of 1 to about 4 carbon atoms, optionally substituted by hydroxy or one or more halogen atoms, or when Z1 represents a direct bond R1 may also represent a lower alkenyl or lower alkynyl group, or a formyl group; R2 represents hydrogen, alkenyl, alkoxy, alkyl, alkylsulphinyl, alkylsulphonyl, alkylthio, aryl, arylalkyloxy, arylalkylsulphinyl, arylalkylsulphonyl, arylalkylthio, aryloxy, arylsulphinyl, arylsulphonyl, arylthio, cyano, cycloalkenyl, cycloalkenyloxy, cycloalkyl, cycloalkyloxy, heteroaryl, heteroarylalkyloxy, heteroaryloxy, hydroxy, —SO2NR4R5, —NR4SO2R5, —NR4R5, —C(?O)R5, —C(?O)C(?O)R5, —C(?O)NR4R5, —C(?O)OR5, —O(C?O)NR4R5, or

Abstract: An adaptive motion controller for driving a servo motor. The adaptive motion controller has an amplifier including a voltage command which can be set at a voltage at which the amplifier will be operated, a frequency selector which can be set at a frequency at which the amplifier will be operated, a power supply having a current feedback, and a control for driving the servo motor in a test mode wherein the voltage command is set at a selected voltage, and the frequency selector is sequentially set with a series of different frequencies. The servo motor is operated at each frequency, and the frequency of the series of frequencies that has the lowest current feedback is determined and the frequency selector is set at that frequency when the amplifier is operated to drive the servo motor.

Abstract: A pusher mechanism comprising a finger assembly, an upper cylinder including a shaft secured to the finger assembly for displacing the finger assembly between retracted and extended positions, housing means supporting the upper cylinder for pivotal displacement, means for pivotally displacing the upper cylinder from a start location to an end location when the finger assembly is extended including a servomotor, a control including profile generating means for generating a profile having a plurality of constant acceleration segments beginning at selected locations and an amplifier for receiving the profile and for driving the servomotor in response thereto, dynamic electronic clutch means for stopping the servomotor to prevent damage to the pusher mechanism when the pivotal displacement of the upper cylinder to the end location is prevented including the amplifier including means for generating a motor current signal, limit logic means including a corresponding plurality of selected constant current limits cor

Abstract: An amplifier circuit which communicates over a two way bus with a CPU having a profile generating computer for defining at least one profile and which supplies a control signal to a motor. The amplifier circuit has a profile generating computer for generating at least one profile which has been downloaded from the CPU and a motor controller for receiving the profile and for issuing a control signal for the motor.