Patents by Inventor Kevin N. Sill

Kevin N. Sill has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polymer excipients for drug delivery applications
    Patent number: 11891482
    Abstract: The present disclosure relates to the field of polymer chemistry and more particularly to multiblock copolymers comprising a poly(sarcosine) block and a D,L-mixed poly(amino acid) block and uses thereof.
    Type: Grant
    Filed: February 15, 2022
    Date of Patent: February 6, 2024
    Assignee: TYNDALL FORMULATION SERVICES, LLC
    Inventors: Kevin N. Sill, Bradford T. Sullivan
  • Formulations of SN-38 with poly(amino acid) block polymers
    Patent number: 11857630
    Abstract: This disclosure relates to the field of formulations of SN-38 with a poly(amino acid) copolymer and methods of making and using thereof. Compositions herein are drug products suitable for the treatment of cancer.
    Type: Grant
    Filed: January 6, 2021
    Date of Patent: January 2, 2024
    Assignee: TYNDALL FORMULATION SERVICES, LLC
    Inventors: Kevin N. Sill, Bradford T. Sullivan
  • POLY(SARCOSINE) POLYMER EXCIPIENTS
    Publication number: 20230312927
    Abstract: The present disclosure relates to the field of polymer chemistry and more particularly to poly(sarcosine) polymers and uses thereof. The disclosure is also directed to compositions comprising a protein and a poly(sarcosine) polymer and uses thereof.
    Type: Application
    Filed: June 8, 2023
    Publication date: October 5, 2023
    Inventors: Bradford T. Sullivan, Kevin N. Sill
  • Poly(sarcosine) polymer excipients
    Patent number: 11718754
    Abstract: The present disclosure relates to the field of polymer chemistry and more particularly to poly(sarcosine) polymers and uses thereof. The disclosure is also directed to compositions comprising a protein and a poly(sarcosine) polymer and uses thereof.
    Type: Grant
    Filed: November 11, 2022
    Date of Patent: August 8, 2023
    Assignee: CALUSA BIO, LLC
    Inventors: Bradford T. Sullivan, Kevin N. Sill
  • Poly(sarcosine) polymer excipients
    Patent number: 11692099
    Abstract: The present disclosure relates to the field of polymer chemistry and more particularly to poly(sarcosine) polymers and uses thereof. The disclosure is also directed to compositions comprising a protein and a poly(sarcosine) polymer and uses thereof.
    Type: Grant
    Filed: November 11, 2022
    Date of Patent: July 4, 2023
    Assignee: CALUSA BIO, LLC
    Inventors: Bradford T. Sullivan, Kevin N. Sill
  • MELANOCORTIN 1 RECEPTOR LIGANDS AND METHODS OF USE
    Publication number: 20230167154
    Abstract: The subject invention pertains to a modified MC1R peptide ligand comprising a peptide that is a melanocortin 1 receptor (MC1R) ligand and a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MC1R peptide ligand can be coupled, e.g., via a click reaction with a complementary click functionality attached, to a moiety to form an MC1R-targeted agent. Drugs, contrast agents, polymers, particles, micelles, surfaces of larger structures, or other moieties can be targeted to the MC1R. The subject invention also pertains to a MC1R peptide ligand-micelle complex comprising a peptide that is a melanocortin 1 receptor ligand connected via a click reaction product to a micelle. The micelle is stable in vivo and can target melanoma tumor cells by association of the peptide ligand with the MC1R or the tumor and selectively provide a detectable and/or therapeutic agent (such as an imageable contrast agent and/or anti-cancer agent) selectively to the tumor cell.
    Type: Application
    Filed: January 24, 2022
    Publication date: June 1, 2023
    Inventors: ROBERT J. GILLIES, DAVID L. MORSE, NATALIE M. BARKEY, KEVIN N. SILL, JOSEF VAGNER, NARGES K. TAFRESHI, JONATHAN L. SESSLER, CHRISTIAN PREIHS, VICTOR J. HRUBY
  • POLY(SARCOSINE) POLYMER EXCIPIENTS
    Publication number: 20230142365
    Abstract: The present disclosure relates to the field of polymer chemistry and more particularly to poly(sarcosine) polymers and uses thereof. The disclosure is also directed to compositions comprising a protein and a poly(sarcosine) polymer and uses thereof.
    Type: Application
    Filed: November 11, 2022
    Publication date: May 11, 2023
    Inventors: Bradford T. Sullivan, Kevin N. Sill
  • POLY(SARCOSINE) POLYMER EXCIPIENTS
    Publication number: 20230142999
    Abstract: The present disclosure relates to the field of polymer chemistry and more particularly to poly(sarcosine) polymers and uses thereof. The disclosure is also directed to compositions comprising a protein and a poly(sarcosine) polymer and uses thereof.
    Type: Application
    Filed: November 11, 2022
    Publication date: May 11, 2023
    Inventors: Bradford T. Sullivan, Kevin N. Sill
  • Compositions of ixabepilone
    Patent number: 11478505
    Abstract: Provided herein are compositions comprising ixabepilone, or a pharmaceutically acceptable salt thereof, and a copolymer represented by formula I: Also provided are methods of treating cancer using the compositions described herein, and methods of preparing the compositions.
    Type: Grant
    Filed: January 8, 2021
    Date of Patent: October 25, 2022
    Assignee: R-Pharm US Operating LLC
    Inventors: Kevin N. Sill, Bradford T. Sullivan
  • POLYMER EXCIPIENTS FOR DRUG DELIVERY APPLICATIONS
    Publication number: 20220251296
    Abstract: The present disclosure relates to the field of polymer chemistry and more particularly to multiblock copolymers comprising a poly(sarcosine) block and a D,L-mixed poly(amino acid) block and uses thereof.
    Type: Application
    Filed: February 15, 2022
    Publication date: August 11, 2022
    Inventors: Kevin N. Sill, Bradford T. Sullivan
  • Polymer excipients for drug delivery applications
    Patent number: 11286344
    Abstract: The present disclosure relates to the field of polymer chemistry and more particularly to multiblock copolymers comprising a poly(sarcosine) block and a D,L-mixed poly(amino acid) block and uses thereof.
    Type: Grant
    Filed: January 10, 2020
    Date of Patent: March 29, 2022
    Assignee: Tyndall Formulation Services, LLC
    Inventors: Kevin N. Sill, Bradford T. Sullivan
  • Melanocortin 1 receptor ligands and methods of use
    Patent number: 11230568
    Abstract: The subject invention pertains to a modified MC1R peptide ligand comprising a peptide that is a melanocortin 1 receptor (MC1R) ligand and a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MC1R peptide ligand can be coupled, e.g., via a click reaction with a complementary click functionality attached, to a moiety to form an MC1R-targeted agent. Drugs, contrast agents, polymers, particles, micelles, surfaces of larger structures, or other moieties can be targeted to the MC1R. The subject invention also pertains to a MC1R peptide ligand-micelle complex comprising a peptide that is a melanocortin 1 receptor ligand connected via a click reaction product to a micelle. The micelle is stable in vivo and can target melanoma tumor cells by association of the peptide ligand with the MC1R or the tumor and selectively provide a detectable and/or therapeutic agent (such as an imageable contrast agent and/or anti-cancer agent) selectively to the tumor cell.
    Type: Grant
    Filed: June 24, 2019
    Date of Patent: January 25, 2022
    Assignees: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC., INTEZYNE TECHNOLOGIES INC., ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA, BOARD OF REGENTS, UNTVERSITY OF TEXAS SYSTEM
    Inventors: Robert J. Gillies, David L. Morse, Natalie M. Barkey, Kevin N. Sill, Josef Vagner, Narges K. Tafreshi, Jonathan L. Sessler, Christian Preihs, Victor J. Hruby
  • Compositions of Ixabepilone
    Publication number: 20210213044
    Abstract: Provided herein are compositions comprising ixabepilone, or a pharmaceutically acceptable salt thereof, and a copolymer represented by formula I: Also provided are methods of treating cancer using the compositions described herein, and methods of preparing the compositions.
    Type: Application
    Filed: January 8, 2021
    Publication date: July 15, 2021
    Inventors: Kevin N. Sill, Bradford T. Sullivan
  • FORMULATIONS OF SN-38 WITH POLY(AMINO ACID) BLOCK POLYMERS
    Publication number: 20210213132
    Abstract: This disclosure relates to the field of formulations of SN-38 with a poly(amino acid) copolymer and methods of making and using thereof. Compositions herein are drug products suitable for the treatment of cancer.
    Type: Application
    Filed: January 6, 2021
    Publication date: July 15, 2021
    Inventors: Kevin N. Sill, Bradford T. Sullivan
  • POLYMER EXCIPIENTS FOR DRUG DELIVERY APPLICATIONS
    Publication number: 20210214496
    Abstract: The present disclosure relates to the field of polymer chemistry and more particularly to multiblock copolymers comprising a poly(sarcosine) block and a D,L-mixed poly(amino acid) block and uses thereof.
    Type: Application
    Filed: January 10, 2020
    Publication date: July 15, 2021
    Inventors: Kevin N. Sill, Bradford T. Sullivan
  • Formulations of paclitaxel with poly(amino acid) block polymers
    Patent number: 10918619
    Abstract: This disclosure relates to the field of formulations of paclitaxel with a poly(amino acid) copolymer and methods of making and using thereof. Compositions herein are drug products suitable for the treatment of cancers.
    Type: Grant
    Filed: January 10, 2020
    Date of Patent: February 16, 2021
    Assignee: Tyndall Formulation Services, LLC
    Inventors: Kevin N. Sill, Bradford T. Sullivan
  • SN-38 loaded iron crosslinked micelle and methods thereof
    Patent number: 10857147
    Abstract: The present invention provides SN-38 compositions for treating cancer.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: December 8, 2020
    Assignee: Intezyne Technologies, Inc.
    Inventors: Kevin N. Sill, Adam Carie
  • Polymer excipients for drug delivery applications
    Patent number: 10836869
    Abstract: The present disclosure relates to the field of polymer chemistry and more particularly to multiblock copolymers comprising a poly(sarcosine) block and a D,L-mixed poly(amino acid) block and uses thereof.
    Type: Grant
    Filed: January 10, 2020
    Date of Patent: November 17, 2020
    Assignee: Tyndall Formulation Services, LLC
    Inventors: Kevin N. Sill, Bradford T. Sullivan
  • MELANOCORTIN 1 RECEPTOR LIGANDS AND METHODS OF USE
    Publication number: 20200002376
    Abstract: The subject invention pertains to a modified MC1R peptide ligand comprising a peptide that is a melanocortin 1 receptor (MC1R) ligand and a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MC1R peptide ligand can be coupled, e.g., via a click reaction with a complementary click functionality attached, to a moiety to form an MC1R-targeted agent. Drugs, contrast agents, polymers, particles, micelles, surfaces of larger structures, or other moieties can be targeted to the MC1R. The subject invention also pertains to a MC1R peptide ligand-micelle complex comprising a peptide that is a melanocortin 1 receptor ligand connected via a click reaction product to a micelle. The micelle is stable in vivo and can target melanoma tumor cells by association of the peptide ligand with the MC1R or the tumor and selectively provide a detectable and/or therapeutic agent (such as an imageable contrast agent and/or anti-cancer agent) selectively to the tumor cell.
    Type: Application
    Filed: June 24, 2019
    Publication date: January 2, 2020
    Inventors: ROBERT J. GILLIES, DAVID L. MORSE, NATALIE M. BARKEY, KEVIN N. SILL, JOSEF VAGNER, NARGES K. TAFRESHI, JONATHAN L. SESSLER, CHRISTIAN PREIHS, VICTOR J. HRUBY
  • SN-38 LOADED IRON CROSSLINKED MICELLE AND METHODS THEREOF
    Publication number: 20190321353
    Abstract: The present invention provides SN-38 compositions for treating cancer.
    Type: Application
    Filed: November 19, 2018
    Publication date: October 24, 2019
    Inventors: Kevin N. Sill, Adam Carie