Abstract: The present invention relates to pyridazinones and related compounds which are inhibitors of PARP7 and are useful in the treatment of cancer.

Abstract: A neuromodulation system including a catheter has a balloon along its distal end. An ultrasound transducer positioned within an interior of the balloon can be selectively activated to emit acoustic energy radially outwardly, targeting nerve tissue and other portions of the subject anatomy. Targeted nerve tissue can be heated by the application of ultrasonic energy to neuromodulate the tissue. The system may be delivered over a guidewire. A catheter enhances fluid delivery to a distal end of the catheter while reducing an overall diameter of the catheter. The catheter comprises a guidewire lumen that is eccentric relative to a center axis of the catheter.

Abstract: The present disclosure provides substituted cyclohexylamine compounds having Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2a, R2b, R3a, R3b, R4, R5, and R7 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.

Abstract: Method and system for treating a patient using a compressible, pressure-attenuating device. According to one embodiment, the system is used to treat urinary tract disorders and comprises an access device, a delivery device, a pressure-attenuating device, and a removal device. The access device can be used to create a passageway to an anatomical structure, such as the patient's bladder. The delivery device can be inserted through the passageway created by the access device and can be used to deliver the pressure-attenuating device to the anatomical structure. The removal device can be inserted through the passageway created by the access device and can be used to view the bladder and/or to capture, to deflate and to remove the pressure-attenuating device.

Abstract: The apparatus includes a standard computer processor in operation receiving a plurality of stimulus-value signals. The apparatus includes a standard computer-readable medium storing instructions that, when executed by the processor, cause the processor to carry out a method for identifying at least one chemical of interest. The method includes the following. A chromaticity chart including a plurality of chemical groupings is generated. The at least one chemical of interest is classified as belonging to a respective chemical grouping of the plurality of chemical groupings based on the chromaticity chart and the plurality of stimulus-value signals. Optionally, the chromaticity chart includes a molecular vibrational chart.

Abstract: Systems, devices, and methods for performing remote sensing using WMA. Embodiments include modulating an interrogation signal, transmitting the interrogation signal to a remote vibrating target, and receiving, at a first port of a WMA interferometer, a reflected signal. Embodiments also include splitting, by a first beam splitter, the reflected signal into first and second portions propagating down first and second waveguides, delaying, by a delay element, a phase of the reflected signal, and spatially phase shifting the reflected signal. Embodiments may further include splitting, by a second beam splitter, the first and second portions of the reflected signal into third and fourth portions propagating down the first and second waveguides, detecting an intensity difference between a first lobe and a second lobe of the third portion of the reflected signal, and calculating a Doppler frequency based on the intensity difference.

Abstract: Compounds, compositions, and methods for treatment of, or prophylaxis against, inflammation and/or oxidative stress are disclosed.

Abstract: A first conductor is embedded in the first dielectric layer to a first wear depth, where the first wear depth is associated with a first threshold wear level. A second dielectric layer overlies the first dielectric layer to a second wear depth. The second wear depth is associated with a second threshold wear level greater than the first threshold wear level. A second conductor is embedded in the second dielectric layer and separate from the first conductor. An indicator is adapted to indicate whether the wear plate is the first threshold wear level or the second threshold wear level.

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

Abstract: High-connection density and bandwidth fiber optic apparatuses and related equipment and methods are disclosed. In certain embodiments, fiber optic apparatuses are provided and comprise a chassis defining one or more U space fiber optic equipment units. At least one of the one or more U space fiber optic equipment units may be configured to support particular fiber optic connection densities and bandwidths in a given 1-U space. The fiber optic connection densities and bandwidths may be supported by one or more fiber optic components, including but not limited to fiber optic adapters and fiber optic connectors, including but not limited to simplex, duplex, and other multi-fiber optic components. The fiber optic components may also be disposed in fiber optic modules, fiber optic patch panels, or other types of fiber optic equipment.

Abstract: A fluid device for a bicycle may be provided to vent fluid from a hydraulic chamber of a seating component such as an adjustable seating assembly for a bicycle. The fluid device may be operable to vent a compressible fluid or a mixed combination flow of compressible and non-compressible fluids in a metered volume. The fluid device may recycle fluids preferentially.

Abstract: A dynamic zooming system may use overlays to display usage information over associated webpages. In one example, a replay manager may zoom-in on particular areas of the webpages to view more specific usage information. In another example, the replay manager may zoom-out the webpages to view more general usage information. The dynamic zooming system may use a first scaled overlay layer to dynamically vary a zoom level of the usage information to match a zoom level for the webpages. The dynamic zooming system also may use a second fixed overlay layer to display other usage information independently of the zoom-level for the webpages.

Abstract: Systems and methods for replacing a 2D image with an equivalent 3D image within a web page. Content of a 2D image displayed within a web page may be identified and 3D images may be identified as possible replacements of the 2D image. The 3D images may be ranked based on sets of ranking criteria. A 3D image with a highest-ranking value may be selected based on a ranking of the 3D images. The selected 3D image may be integrated into the web page, thereby replacing the 2D image with the selected 3D image. Further, a user input manipulating the 3D image within the web page may be received. The user input may include movement of a view point of a user relative to a display displaying the web page and/or detection of a beam projected from an end of a user input device intersecting with the 3D image.

Abstract: Aspects of the disclosure relate to cloud computing architectures. A system may include a plurality of clouds. One or more of the clouds may transfer data to another one or more of the clouds. A data integration platform may control the data transfer. The transfer may be securely routed through the data integration platform. The transfer may be logged, and the log may be transmitted to an administrative network.

Abstract: Absorbent articles designed and configured to leverage a greater amount of plant-derived materials and/or to minimize the inclusion of unwanted materials towards providing a more pure end product to consumers desiring the same are described.

Abstract: The present application describes a monoblock container, with wheels, consisting of two compartments intended, for example, for product storage and transportation. The monoblock container is formed in one piece, which is divided in two compartments of distinct dimensions, favouring the segmentation of products to be stored/transported among said compartments.

Abstract: An integral check valve has a stem with a first interior bore extending longitudinally inward from a first end thereof and a spindle having a central shaft having a first end and an opposing second end with flange circumscribing the central shaft. The interior bore is sized to receive the stem and a portion of the central shaft extending from the first end to the flange. The integral check valve may be a component of a plumbing fixture that further includes a hollow body having a water inlet, a water outlet and an integral check valve receiving conduit. The integral check valve receiving conduit has threads sized to engage the outwardly extending threads of the stem.

Abstract: A drain assembly for being placed inground includes a first panel and a second panel spaced-apart from the first panel, a plurality of supports extending between the first panel and the second panel, a bottom or pipe extending between a bottom portion of the first panel and the second panel, and a cap extending between a top portion of the first panel and the second panel. The first panel may define a plurality of drainage apertures. A related method is also provided.

Abstract: A dust hood (100), including a flange (90) for fastening the dust hood (100) to a transmission extension housing (210) of an angle grinder (200), and including a hood body (10) for covering a circular cutting wheel (220) on both sides, at least in sections, and including a suction connecting piece (40) for connecting a suction hose (400), via which removed substrate material (UG) may be extracted from the hood body (10), the dust hood (100) including a sensor unit (20), with the aid of which it is possible to detect whether the suction hose (20) is connected to the suction connecting piece (40) and/or whether a flap (45) of the suction connecting piece (40) is open.

Abstract: A system and method include receiving, by an authentication system, device data of a computing device used by a customer during a checkout process of a current transaction on a merchant website and contextual data of the customer. The system and method also include retrieving a customer token associated with a payment instrument of the customer, assigning the computing device a device score and the customer a customer score based on the device data and the contextual data, and computing an overall score from the device score and the customer score. The system and method further include determining from the overall score that the current transaction is not fraudulent before the current transaction is completed and auto-filling payment information of the payment instrument in the customer token during the checkout process of the merchant website to complete the current transaction upon determining that the current transaction is not fraudulent.