Patents by Inventor Kevin P. Brower

Kevin P. Brower has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of Controlling the Formation of Disulfide Bonds in Protein Solutions
    Publication number: 20240392030
    Abstract: Disclosed herein are methods that have been developed to control the formation of disulfide bonds between polypeptides of a multimeric protein produced by a bioprocess. Also disclosed are protein solution parameters that allow for controlling the formation of disulfide bonds. In one example, the methods disclosed herein can be used to control the proportion of half antibody molecules in an antibody solution.
    Type: Application
    Filed: August 1, 2024
    Publication date: November 28, 2024
    Inventors: Kevin P. BROWER, Chris HWANG, Rao KODURI, Konstantin B. KONSTANTINOV, Veena WARIKOO, Jin YIN, Marcella YU
  • Methods of Controlling the Formation of Disulfide Bonds in Protein Solutions
    Publication number: 20200299402
    Abstract: Disclosed herein are methods that have been developed to control the formation of disulfide bonds between polypeptides of a multimeric protein produced by a bioprocess. Also disclosed are protein solution parameters that allow for controlling the formation of disulfide bonds. In one example, the methods disclosed herein can be used to control the proportion of half antibody molecules in an antibody solution.
    Type: Application
    Filed: April 8, 2020
    Publication date: September 24, 2020
    Inventors: Kevin P. Brower, Chris Hwang, Rao Koduri, Konstantin B. Konstantinov, Veena Warikoo, Jin Yin, Marcella Yu
  • Methods of controlling the formation of disulfide bonds in protein solutions
    Patent number: 10647777
    Abstract: Disclosed herein are methods that have been developed to control the formation of disulfide bonds between polypeptides of a multimeric protein produced by a bioprocess. Also disclosed are protein solution parameters that allow for controlling the formation of disulfide bonds. In one example, the methods disclosed herein can be used to control the proportion of half antibody molecules in an antibody solution.
    Type: Grant
    Filed: March 25, 2015
    Date of Patent: May 12, 2020
    Assignee: GENZYME CORPORATION
    Inventors: Kevin P. Brower, Chris Hwang, Rao Koduri, Konstantin B. Konstantinov, Veena Warikoo, Marcella Yu, Jin Yin
  • Methods of Controlling the Formation of Disulfide Bonds in Protein Solutions
    Publication number: 20160108127
    Abstract: Disclosed herein are methods that have been developed to control the formation of disulfide bonds between polypeptides of a multimeric protein produced by a bioprocess. Also disclosed are protein solution parameters that allow for controlling the formation of disulfide bonds. In one example, the methods disclosed herein can be used to control the proportion of half antibody molecules in an antibody solution.
    Type: Application
    Filed: March 25, 2015
    Publication date: April 21, 2016
    Inventors: Kevin P. Brower, Chris Hwang, Rao Koduri, Konstantin B. Konstantinov, Veena Warikoo, Jin Yin, Marcella Yu