Patents by Inventor Kevin P. Francis

Kevin P. Francis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • In vivo imaging of enzymatic activity
    Patent number: 9446151
    Abstract: Compositions and methods are described for detecting enzyme activity in a live organism (e.g., animal) are provided.
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: September 20, 2016
    Assignee: Caliper Life Sciences, Inc.
    Inventors: Daniel Ansaldi, Kevin P. Francis, Rajendra Singh, Ning Zhang
  • IN VIVO IMAGING OF ENZYMATIC ACTIVITY
    Publication number: 20130101511
    Abstract: Compositions and methods are described for detecting enzyme activity in a live organism (e.g., animal) are provided.
    Type: Application
    Filed: April 13, 2012
    Publication date: April 25, 2013
    Inventors: Daniel Ansaldi, Kevin P. Francis, Rajendra Singh, Ning Zhang
  • Methods of screening for introduction of DNA into a target cell
    Patent number: 8372597
    Abstract: The present invention provides methods of introducing a polynucleotide into a target cell, wherein the method employs a light generating protein coding sequence acting as a reporter. An important advantage of the methods described herein is that drug resistant target cells or target cells having no useful auxotrophic markers can be effectively transformed. The present invention also includes transformed cells produced by the methods described herein. Also described are light generating protein coding sequence modifications, a variety of vectors, and methods of using the transformed cells of the present invention.
    Type: Grant
    Filed: May 4, 2006
    Date of Patent: February 12, 2013
    Assignee: Xenogen Corporation
    Inventors: Kevin P. Francis, Timothy C. Doyle, Kevin A. Nawotka
  • Methods of screening for introduction of DNA into a target cell
    Patent number: 7090994
    Abstract: The present invention provides methods of introducing a polynucleotide into a target cell, wherein the method employs a light generating protein coding sequence acting as a reporter. An important advantage of the methods described herein is that drug resistant target cells or target cells having no useful auxotrophic markers can be effectively transformed. The present invention also includes transformed cells produced by the methods described herein. Also described are light generating protein coding sequence modifications, a variety of vectors, and methods of using the transformed cells of the present invention.
    Type: Grant
    Filed: March 7, 2002
    Date of Patent: August 15, 2006
    Assignee: Xenogen Corporation
    Inventors: Kevin P. Francis, Timothy C. Doyle, Kevin A. Nawotka
  • Compositions and methods for use thereof in modifying the genomes of microorganisms
    Patent number: 7056728
    Abstract: The present invention relates to bacterial luciferase transposon cassettes suitable for conferring bioluminescence properties on a Gram-positive bacteria, Gram-negative bacteria, and other organisms of interest. The invention further includes cells transformed with vectors carrying the transposon cassettes, cells whose genomes have been modified by introduction of such cassettes, and methods of making and using such transposon cassettes, transposon cassette vectors, and cells containing the transposons.
    Type: Grant
    Filed: June 21, 2001
    Date of Patent: June 6, 2006
    Assignee: Xenogen Corporation
    Inventors: Kevin P. Francis, Anthony F. Purchio
  • Luciferase expression cassettes and methods of use
    Patent number: 6737245
    Abstract: The present invention relates to bacterial luciferase expression cassettes suitable for conferring bioluminescence properties on Gram-positive bacteria, cells transformed with such cassettes, and methods of making and using such cassettes.
    Type: Grant
    Filed: September 7, 2000
    Date of Patent: May 18, 2004
    Assignee: Xenogen Corporation
    Inventors: Kevin P. Francis, Pamela R. Contag, Danny J. Joh
  • Methods of screening for introduction of DNA into a target cell
    Publication number: 20020192755
    Abstract: The present invention provides methods of introducing a polynucleotide into a target cell, wherein the method employs a light generating protein coding sequence acting as a reporter. An important advantage of the methods described herein is that drug resistant target cells or target cells having no useful auxotrophic markers can be effectively transformed. The present invention also includes transformed cells produced by the methods described herein. Also described are light generating protein coding sequence modifications, a variety of vectors, and methods of using the transformed cells of the present invention.
    Type: Application
    Filed: March 7, 2002
    Publication date: December 19, 2002
    Inventors: Kevin P. Francis, Timothy C. Doyle, Kevin A. Nawotka
  • Compositions and methods for use thereof in modifying the genomes of microorganisms
    Publication number: 20020137215
    Abstract: The present invention relates to bacterial luciferase transposon cassettes suitable for conferring bioluminescence properties on a Gram-positive bacteria, Gram-negative bacteria, and other organisms of interest. The invention further includes cells transformed with vectors carrying the transposon cassettes, cells whose genomes have been modified by introduction of such cassettes, and methods of making and using such transposon cassettes, transposon cassette vectors, and cells containing the transposons.
    Type: Application
    Filed: June 21, 2001
    Publication date: September 26, 2002
    Inventors: Kevin P. Francis, Anthony F. Purchio