Abstract: Provided herein are methods for design of engineered polypeptides that recapitulate molecular structure features of a predetermined portion of several reference protein structures, e.g., related antibody epitopes or protein binding sites. A Machine Learning (ML) model may be used to generate engineered polypeptides. After substituting target residues for corresponding residues in other reference structures in the same scaffold, the scaffolds with each set of target residues may be filtered by structural comparison to identify generalized scaffolds. Generalized scaffolds may be improved by screening libraries of polypeptides.

Abstract: A testing system for monitoring a machine under test is disclosed and includes one or more high frequency sensors configured to generate a sensor signal that is representative of an operating parameter of the machine. The high frequency sensors have a required high frequency sampling rate. The testing system also includes a notification device configured to generate a notification indicating the operating parameter monitored by the high frequency sensors has exceeded a predefined threshold value and a data acquisition control module configured to monitor the high frequency sensors at a first sampling rate. The testing system also includes a monitoring control module in electronic communication with the notification device. The monitoring control module is configured to monitor the high frequency sensors at a second sampling rate that is greater than the first sampling rate and at least equal to the required high frequency sampling rate.

Abstract: A testing system for monitoring a machine under test is disclosed and includes one or more high frequency sensors configured to generate a sensor signal that is representative of an operating parameter of the machine. The high frequency sensors have a required high frequency sampling rate. The testing system also includes a notification device configured to generate a notification indicating the operating parameter monitored by the high frequency sensors has exceeded a predefined threshold value and a data acquisition control module configured to monitor the high frequency sensors at a first sampling rate. The testing system also includes a monitoring control module in electronic communication with the notification device. The monitoring control module is configured to monitor the high frequency sensors at a second sampling rate that is greater than the first sampling rate and at least equal to the required high frequency sampling rate.

Abstract: An online data validator is a digital imaging system integrated onto the front side of a printing unit wherein an exit of the printing unit is set on the same side close to the online data validator for a media exiting therefrom. The online data validator comprises a controller facilitating communication with a printing unit controller and controlling overall operation of the online data validator functions; a camera module including a sensor PCB and an optical lens, wherein the sensor PCB contains a camera sensor for capturing 2D digital images of moving labels; and a light source module including a lightbar, a lightbar PCB, a Fresnel lens and a window for providing uniform and flattened illumination on the media.

Abstract: An online data validator is a digital imaging system integrated onto the front side of a printing unit wherein an exit of the printing unit is set on the same side close to the online data validator for a media exiting therefrom. The online data validator comprises a controller facilitating communication with a printing unit controller and controlling overall operation of the online data validator functions; a camera module including a sensor PCB and an optical lens, wherein the sensor PCB contains a camera sensor for capturing 2D digital images of moving labels; and a light source module including a lightbar, a lightbar PCB, a Fresnel lens and a window for providing uniform and flattened illumination on the media.

Abstract: In one embodiment, an intelligent printer ribbon cartridge includes a microcontroller that monitors sensors related to the ribbon cartridge for use in a line matrix printer. The ribbon cartridge contains an impact printing ribbon in the form of either a simple loop, a mobius loop, or a long strip of ribbon connected to two spools, with one spool at each end of the cartridge. The ribbon cartridge is able to monitor at least one motion sensor, process the information, and perform a suitable action or communicate an action or information to the printer. This allows the ribbon cartridge to adapt or instruct the printer to adapt with any new types of ribbons, ribbon cartridges, formats, etc. so that the printing may occur with virtually any type of ribbon/cartridge.

Abstract: In one embodiment, an intelligent printer ribbon cartridge includes a microcontroller that monitors sensors related to the ribbon cartridge for use in a line matrix printer. The ribbon cartridge contains an impact printing ribbon in the form of either a simple loop, a mobius loop, or a long strip of ribbon connected to two spools, with one spool at each end of the cartridge. The ribbon cartridge is able to monitor at least one motion sensor, process the information, and perform a suitable action or communicate an action or information to the printer. This allows the ribbon cartridge to adapt or instruct the printer to adapt with any new types of ribbons, ribbon cartridges, formats, etc. so that the printing may occur with virtually any type of ribbon/cartridge.

Abstract: A ribbon identification system detects a digitally encoded tract comprised of radially printed bands of dark and light areas positioned on a ribbon spool that fits on a media printing device. Each type and length of ribbon to be used is associated with a specific and unique digitally encoded tract. When the ribbon spool is positioned correctly on the printing device, the digitally encoded tract is detected, and the control program of the printing device sets the parameters associated with that ribbon automatically ensuring proper printing. Through the digitally encoded tract, the ribbon spool is uniquely identified so that once it has been determined by the printing device's control program that the ribbon has been depleted, that ribbon spool, if reinstalled on the same printing device at a later time, will be recognized as a depleted ribbon, and the printing device will not function.

Abstract: A ribbon identification system detects a digitally encoded tract comprised of radially printed bands of dark and light areas positioned on a ribbon spool that fits on a media printing device. Each type and length of ribbon to be used is associated with a specific and unique digitally encoded tract. When the ribbon spool is positioned correctly on the printing device, the digitally encoded tract is detected, and the control program of the printing device sets the parameters associated with that ribbon automatically ensuring proper printing. Through the digitally encoded tract, the ribbon spool is uniquely identified so that once it has been determined by the printing device's control program that the ribbon has been depleted, that ribbon spool, if reinstalled on the same printing device at a later time, will be recognized as a depleted ribbon, and the printing device will not function.

Abstract: An ink density closed loop control system for an ink ribbon of an impact printer having a reservoir roller formed of an ink absorbent material with at least one or more channels within the reservoir roller fluidly connected to a pump and ink supply. A transfer roller can contact the reservoir roller for imparting ink to the ink ribbon. A sensor senses the relative amount of ink on the print ribbon and an electrical drive responsive to the sensor drives the pump for a flow of ink to the one or more channels. The sensor can sense ink on different segments of the ribbon and, with two or more channels in the reservoir roller can distribute ink to two or more segments of the reservoir roller depending upon the ink sensed at a particular segment of the ribbon. A further enhancement of this invention provides a multi-viscosity ink to compensate for changes in ambient temperature conditions.

Abstract: A thermal printer utilizing a platen on which media can move over a print head in association with print ribbon from a supply spool driven by motors connected to a print ribbon supply and take-up with a program to provide current settings and engine control to the ribbon. The printer further has a ribbon support, a program, and a processor connected to a drive for causing the drive to move the support in response to ribbon width. The printer has a control panel, a file system with current settings connected to the file system, and further includes engine control software for controlling the printer functions including print head pressure, print head temperature, and a ribbon support based upon the width of the print ribbon.

Abstract: An ink density closed loop control system for an ink ribbon of an impact printer having a reservoir roller formed of an ink absorbent material with at least one or more channels within the reservoir roller fluidly connected to a pump and ink supply. A transfer roller can contact the reservoir roller for imparting ink to the ink ribbon. A sensor senses the relative amount of ink on the print ribbon and an electrical drive responsive to the sensor drives the pump for a flow of ink to the one or more channels. The sensor can sense ink on different segments of the ribbon and, with two or more channels in the reservoir roller can distribute ink to two or more segments of the reservoir roller depending upon the ink sensed at a particular segment of the ribbon. A further enhancement of this invention provides a multi-viscosity ink to compensate for changes in ambient temperature conditions.

Abstract: A thermal printer utilizing a platen on which media can move over a print head in association with print ribbon from a supply spool driven by motors connected to a print ribbon supply and take-up with a program to provide current settings and engine control to the ribbon. The printer further has a ribbon support, a program, and a processor connected to a drive for causing the drive to move the support in response to ribbon width. The printer has a control panel, a file system with current settings connected to the file system, and further includes engine control software for controlling the printer functions including print head pressure, print head temperature, and a ribbon support based upon the width of the print ribbon.

Abstract: A thermal printer having a supply of media with a rotatable platen on which the media is moved for printing by a thermal printing head. A supply spindle supplies print ribbon from a supply spool mounted thereon, and a take-up spindle takes up the used print ribbon on a take-up spool. The spindles are each driven by a motor and controlled by a controller which detects the Back EMF (BEMF) of the motors, and calculates the velocity of the spindles, spool, and print ribbon to control each motor based on the BEMF. The status of the print ribbon as to low condition, breaks, ribbon full and other monitoring functions can be provided to a remote host computer or other monitoring station.

Abstract: A dot matrix printer having a plurality of hammers forming in part a hammerbank, with a motor for driving the hammerbank, and a controller for releasing the hammers for printing on a print media. A counterbalance is mechanically linked to the hammerbank for balancing it during movement. Lands and grooves are connected for rotation with the motor. A sensor sends pulses corresponding to the lands and grooves for controlling the hammerbank movement. The hammerbank is linked to the position of the lands and grooves as mechanically connected to the motor.