Abstract: Provided herein are combinations comprising a glucagon-like peptide-1 receptor (GLP-1R) agonist and a thyroid hormone receptor beta (THR?) agonist and methods comprising administering to a subject in need thereof such combinations.

Abstract: Provided herein are combinations comprising a glucagon-like peptide-1 receptor (GLP-1R) agonist and a thyroid hormone receptor beta (THR?) agonist and methods comprising administering to a subject in need thereof such combinations.

Abstract: The present application provides compounds that may be used as a glucagon-like peptide-1 receptors (GLP-1R) agonist, or pharmaceutically acceptable salts thereof. Also provided are pharmaceutical compositions containing such compounds, or pharmaceutically acceptable salts thereof. Methods of preparing these compounds and compositions, and methods of using these compounds and compositions to treat or prevent a disease or a condition mediated by GLP-1R, are also provided.

Abstract: A clamping circuit for clamping a circuit node during an initial circuit powerup interval includes a switching circuit and a switching control circuit. The switching circuit is an N-MOSFET with its drain and source terminals connected to circuit ground and the subject node sought to be clamped, respectively, and its gate terminal connected to the switching control circuit. The switching control circuit includes a number of N-MOSFETs which are interconnected in such a manner as to receive the power supply voltage and generate a switching signal which turns the switching circuit N-MOSFET on during an initial circuit powerup interval to clamp the subject node and then off after the power supply has reached a preselected minimum value. Upon initial circuit powerup, the switching control circuit self-triggers itself to turn the switching circuit on and clamp the subject node at ground potential.