Patents by Inventor Kevin Pagel

Kevin Pagel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dendritic detergents for the analysis of proteins by mass spectrometry
    Patent number: 12122805
    Abstract: A method of detecting a protein by mass spectrometry comprises: providing a solution comprising a dendritic detergent and a protein; providing a mass spectrometer comprising a nanoelectrospray ionisation source, a mass analyser and a detector; vaporising the solution using the nanoelectrospray ionisation source; ionising the protein; resolving the ionised protein using the mass analyser; and detecting the resolved protein using the detector. A method of extracting a membrane protein from its native membrane comprises: providing a membrane protein in its native membrane; contacting the membrane protein with a dendritic detergent. Dendritic detergents for use in the methods are also provided.
    Type: Grant
    Filed: September 4, 2019
    Date of Patent: October 22, 2024
    Assignees: OXFORD UNIVERSITY INNOVATION LIMITED, FREIE UNIVERSITÄT BERLIN
    Inventors: Carol V. Robinson, Idlir Liko, Hsin-Yung Yen, Kevin Pagel, Rainer Haag, Svenja Christina Ehrmann, Leonhard Hagen Urner
  • DETERGENTS AND METHODS
    Publication number: 20240264164
    Abstract: A method of detecting a protein by mass spectrometry comprises: providing a solution comprising a hybrid detergent and a protein; providing a mass spectrometer comprising a nanoelectrospray ionisation source; vaporising the solution; ionising the protein; resolving the ionised protein; and detecting the resolved protein. The mass spectrometry methods may be used to interrogate the lipidome of a protein of interest, and/or for analysing membrane proteins in the form of complexes with ligands, and in particular lipids.
    Type: Application
    Filed: May 11, 2022
    Publication date: August 8, 2024
    Inventors: Leonhard Hagen URNER, Kevin PAGEL, Rainer HAAG, Dennis SHUTIN, Mark AGASID, Francesco FIORENTINO, Carol V. ROBINSON
  • DENDRITIC DETERGENTS FOR THE ANALYSIS OF PROTEINS BY MASS SPECTROMETRY
    Publication number: 20210188902
    Abstract: A method of detecting a protein by mass spectrometry comprises: providing a solution comprising a dendritic detergent and a protein; providing a mass spectrometer comprising a nanoelectrospray ionisation source, a mass analyser and a detector; vaporising the solution using the nanoelectrospray ionisation source; ionising the protein; resolving the ionised protein using the mass analyser; and detecting the resolved protein using the detector. A method of extracting a membrane protein from its native membrane comprises: providing a membrane protein in its native membrane; contacting the membrane protein with a dendritic detergent. Dendritic detergents for use in the methods are also provided.
    Type: Application
    Filed: September 4, 2019
    Publication date: June 24, 2021
    Inventors: Carol V. Robinson, Idlir Liko, Hsin-Yung Yen, Kevin Pagel, Rainer Haag, Svenja Christina Ehrmann, Leonhard Hagen Urner
  • Method for determining carbohydrates structure
    Patent number: 10359398
    Abstract: The present invention relates to a method for determining in an expedient manner and with minimal sample consumption the structure of an unknown carbohydrate by using ion mobility-mass spectrometry (IM-MS) in negative ionization mode and fragmentation and a database containing structures of carbohydrates and/or of the fragments of the negative ions of carbohydrates, and for each of the structures of the target carbohydrates the collision cross section value and the mass-to-charge ratio value of the negative ion thereof, and for each of the structures of the fragments of the negative ions of the target carbohydrates the collision cross section value and the mass-to-charge ratio value of the fragment of the negative ion of the target carbohydrate.
    Type: Grant
    Filed: September 3, 2015
    Date of Patent: July 23, 2019
    Assignees: Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V., Freie Universitat Berlin
    Inventors: Johanna Hofmann, Heung Sik Hahm, Peter Seeberger, Kevin Pagel
  • METHOD FOR DETERMINING CARBOHYDRATES STRUCTURE
    Publication number: 20180246062
    Abstract: The present invention relates to a method for determining in an expedient manner and with minimal sample consumption the structure of an unknown carbohydrate by using ion mobility-mass spectrometry (IM-MS) in negative ionization mode and fragmentation and a database containing structures of carbohydrates and/or of the fragments of the negative ions of carbohydrates, and for each of the structures of the target carbohydrates the collision cross section value and the mass-to-charge ratio value of the negative ion thereof, and for each of the structures of the fragments of the negative ions of the target carbohydrates the collision cross section value and the mass-to-charge ratio value of the fragment of the negative ion of the target carbohydrate.
    Type: Application
    Filed: September 3, 2015
    Publication date: August 30, 2018
    Applicants: Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V., Freie Universitat Berlin, Freie Universitat Berlin
    Inventors: Johanna Hofmann, Heung Sik Hahm, Peter Seeberger, Kevin Pagel