Abstract: A respiratory humidification system for providing humidification to gases that pass through a gas passage way before being provided to an airway of a patient is disclosed. The respiratory humidification system may include a liquid flow controller providing a controlled flow of liquid, a heating system including a heating surface configured to be located in a gases passage way and provide humidification to gases passing through the passage way, wherein the heating system receives the controlled flow of liquid, and one or more hardware processors providing deterministic control of a humidity level of gases passing through the gas passage way by instructing the liquid flow controller to adjust the controlled flow of liquid received at the heating system.

Abstract: A device is disclosed including a substrate and a floating blinded infrared detector and/or a shunted blinded infrared detector. The floating blinded infrared detector may include an infrared detector coupled to and thermally isolated from the substrate; and a blocking structure disposed above the infrared detector to block external thermal radiation from being received by the infrared detector; and wherein the blocking structure comprises a plurality of openings. The shunted blinded infrared detector may include an additional infrared detector coupled to the substrate; an additional blocking structure disposed above the infrared detector to block external thermal radiation from being received by the additional infrared detector; and a material that thermally couples the additional infrared detector to the substrate and the additional blocking structure. Methods for using and forming the device are also disclosed.

Abstract: The present invention provides a breathing assistance apparatus that has a convenient and effective method of cleaning internal conduits inside the apparatus. The breathing assistance apparatus is preferably a gases supply and humidification device. The cleaning method is a method of disinfection that is automated so minimal training is required to disinfect in particular an internal elbow conduit within the device. It is therefore not necessary to dismantle the gases supply and humidification device, therefore, inadvertent damage to the internal parts of the device is avoided. The present invention also provides a method of disinfecting a heated breathing conduit and a patient interface.

Abstract: Systems and devices for mounting servers are provided. In one aspect, a rack mounting system includes a first mounting bracket attached to a rack. The rack comprises a rack front side and a rack rear side opposite the rack front side. The first mounting bracket is attached to the rack rear side. A rail bracket is attached to a server component mounted in the rack. A second mounting bracket comprises a first end and a second end. The first end is coupled to the first mounting bracket. The second end is coupled to the rail bracket. The second mounting bracket comprises a first surface and a second surface opposite the first surface. The first surface of the second mounting bracket contacts the first mounting bracket. The second surface of the second mounting bracket contacts the rail bracket.

Abstract: Disclosed herein are compositions and methods for treating ocular diseases, inter alia, diabetic macular edema, age-related macular degeneration (wet form), choroidal neovascularization, diabetic retinopathy, retinal vein occlusion (central or branch), ocular trauma, surgery induced edema, surgery induced neovascularization, cystoid macular edema, ocular ischemia, uveitis, and the like. These diseases or conditions are characterized by changes in the ocular vasculature whether progressive or non-progressive, whether a result of an acute disease or condition, or a chronic disease or condition.

Abstract: The disclosure provides compositions and methods for the treatment of ocular conditions associated with angiogenesis comprising administering an antibody that targets a tyrosine phosphatase inhibitor in a subject.

Abstract: The disclosure provides compositions comprising multi-specific compounds, including a compound that targets a phosphatase and a receptor tyrosine kinase agonist. Also provided are methods for the treatment of conditions associated with angiogenesis, comprising administering a multi-specific compound that targets a phosphatase and a receptor tyrosine kinase agonist.

Abstract: The disclosure provides compositions and methods for the treatment of ocular conditions associated with angiogenesis comprising administering an antibody that targets a tyrosine phosphatase inhibitor in a subject.

Abstract: Patient interfaces for respiratory therapy in the form of nasal interfaces or nasal masks include features that enhance or provide lateral stability of the interface. At least some of the embodiments provide multiple facial contact points or areas located in the general areas of the user's cheeks and/or upper lip. Some embodiments of the nasal interfaces provide advantageous sealing characteristics. The nasal interfaces may provide a controlled expiratory flow to reduce noise. Some embodiments include nasal pillows instead of or in addition to nasal prongs. The nasal pillows can have exhaust vents or can change in length in response to a pressure level within the nasal pillow.

Abstract: Provided are systems and methods for producing seamless woven materials that are variable in each of their 3 dimensions. The systems and methods generally operate by altering heddle positions independently to impart three dimensional structure to a woven fabric. Weft yarn is woven into a set of warp yarns that have been individually raised or lowered along a particular cross section, essentially locking the weave into an intended 3 dimensional form.

Abstract: Additive manufacturing systems are disclosed. The additive manufacturing system may include a sintering device configured to sinter a powder material to form a component, and an actuator coupled to the sintering device. The actuator may adjust a position of the sintering device. Additionally, the system may include at least one computing device operably connected to the actuator and the sintering device. The at least one computing device may control a movement of the sintering device by performing processes including determining an exposure pattern for the sintering device for sintering the powder material based on a geometry of the component. The exposure pattern may include at least one exposure track extending between two sides of the component. The computing device(s) may also perform processes including moving the sintering device, using the actuator, in the determined exposure pattern to sinter the powder material to form the component.

Abstract: The gases temperature supplied to a patient when the patient is undergoing treatment such as oxygen therapy or positive pressure treatment for conditions such as Obstructive Sleep Apnea (OSA) or Chronic Obstructive Pulmonary Disease (COPD) is often measured for safety and to enable controlling of the humidity delivered to the patient. The invention disclosed is related to measurement of properties, particularly temperature (thermister 23), of gases flowing through a heated tube (3), supplying gases to a patient, which utilises the heating wire (21, 28) within the tube.

Abstract: Examples described herein include handles with extended and retracted positions. In some examples, a handle comprises a housing and a knob. The knob may have a first surface and a circumferential sidewall. The knob may have a retracted position in the housing and an extended position. In the extended position, the circumferential sidewall protrudes from the housing and the knob is rotatable between a first position and a second position.

Abstract: Disclosed are methods for treating eye diseases or conditions characterized by vascular instability, vascular leakage and neovacularization such as diabetic macular edema, age-related macular edema, choroidal neovascularization, diabetic retinopathy, trauma, ocular ischemia, retinal angiomatous proliferation, macular telangiectasia and uveitis.

Abstract: The present invention provides a breathing assistance apparatus that has a convenient and effective method of cleaning internal conduits inside the apparatus. The breathing assistance apparatus is preferably a gases supply and humidification device. The cleaning method is a method of disinfection that is automated so minimal training is required to disinfect in particular an internal elbow conduit within the device. It is therefore not necessary to dismantle the gases supply and humidification device, therefore, inadvertent damage to the internal parts of the device is avoided. The present invention also provides a method of disinfecting a heated breathing conduit and a patient interface.

Abstract: A nasal cannula assembly is disclosed having a face mount part, in use resting against a user's face, which includes at least one nasal prong capable of being fitted into a person's nares. The cannula assembly also includes a manifold part, in fluid communication with the face mount part, having a single horizontal side gases entry. In particular, this cannula assembly is for supplying heated, humidified gases to a patient suffering from COPD. A tie or lanyard is disclosed for use with a breathing assistance apparatus such as a nasal cannula, face or nasal mask or tracheostomy connector. The tie or lanyard transfers the weight of the conduits supplying gases to the breathing assistance apparatus from the breathing assistance apparatus and distributes it onto the neck of the patient.

Abstract: An example rail kit includes a bracket assembly that is attachable to opposing columns of a device rack, a middle rail that is slidably engaged by the bracket assembly, and an inner rail that is connectable to an electronic device and slidably engaged by the middle rail. The rail kit may include a rail lock that is attached to the bracket assembly and that is to, when the inner rail is not engaged by the middle rail and the middle rail is located at a first position that is forward of a fully retracted position, lock the middle rail by engaging a depression in the middle rail such that the middle rail is prevented from sliding rearward. The rail lock may be released as a result of the inner rail being slid toward a retracted position while engaged by the middle rail.

Abstract: This invention relates to headgear and a patient interface, or components of a headgear or patient interface, such as a nasal cannula. In one embodiment is a size adjustable headstrap to be provided as a headgear or a part thereof, in another is a portion of a headstrap or component for association therewith in which the portion or component facilitates improved location of the strap upon a user's face, in another embodiment is a system for encapsulating or covering a connector from contact with a user's face or facial skin, in another embodiment is a face mount part or body for a patient interface of a particular configuration, and in yet a further embodiment is a gases flow manifold for delivering of gases to a patient interface of a particular configuration for improved patient comfort.

Abstract: A respiratory assistance apparatus is configured to provide a heated and humidified glow of gases and has a control system that is configured to detect a fault in the flow path. A flow path is provided for a gases stream through the apparatus from a gas inlet through a blower unit and humidification unit to a gases outlet. A flow rate sensor is provided in the flow path and is configured to sense the flow rate and generate an flow rate signal and/or a motor speed sensor is provided that is configured to sense the motor speed of the blower unit and generate an indicative motor speed signal.

Abstract: A method of controlling a flow rate of gases supplied to a patient by a respiratory assistance device includes controlling the supply gases flow rate so as to deliver gases to the patient according to a predetermined gases pressure/flow rate profile for at least a portion of the breathing cycle. A profile may be achieved that provides the patient with a particular benefit or therapy.