Patents by Inventor Kevin R. Bracken

Kevin R. Bracken has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bulk drying and the effects of inducing bubble nucleation
    Patent number: 6884866
    Abstract: The present invention discloses apparatus and methods of inducing bubble nucleation to overcome problems commonly associated with preservation by foam formation. Specifically, the invention relates to methods of using bubble nucleation in foam formation to preserve sensitive biological materials. Preferred methods of inducing bubble nucleation include, mixing, chamber rotation, crystals, and ultrasound.
    Type: Grant
    Filed: October 18, 2002
    Date of Patent: April 26, 2005
    Assignee: Avant Immunotherapeutics, Inc.
    Inventors: Victor Bronshtein, Kevin R. Bracken, John G. Cambell
  • Industrial scale barrier technology for preservation of sensitive biological materials
    Patent number: 6692695
    Abstract: This invention relates to barrier methods for preserving sensitive biological materials as a porous foam, subsequently crushing the foam to form a powder, and optionally formulating mixtures of preserved powdered biological materials. The invention also encompasses an apparatus for integrating the methods of foam formation and subsequent crushing of the preserved biological materials using barrier technology.
    Type: Grant
    Filed: June 7, 2000
    Date of Patent: February 17, 2004
    Assignee: Quadrant Drug Delivery Limited
    Inventors: Victor Bronshtein, Kevin R. Bracken, Ronnie K. Livers, David R. Williams
  • Bulk drying and the effects of inducing bubble nucleation
    Publication number: 20030155669
    Abstract: The present invention discloses apparatus and methods of inducing bubble nucleation to overcome problems commonly associated with preservation by foam formation. Specifically, the invention relates to methods of using bubble nucleation in foam formation to preserve sensitive biological materials. Preferred methods of inducing bubble nucleation include, mixing, chamber rotation, crystals, and ultrasound.
    Type: Application
    Filed: October 18, 2002
    Publication date: August 21, 2003
    Inventors: Victor Bronshtein, Kevin R. Bracken, John G. Campbell
  • Industrial scale barrier technology for preservation of sensitive biological materials at ambient temperatures
    Patent number: 6306345
    Abstract: This invention relates to barrier methods for preserving sensitive biological materials as a porous foam, subsequently crushing the foam to form a powder, and optionally formulating mixtures of preserved powdered biological materials. The invention also encompasses an apparatus for integrating the methods of foam formation and subsequent crushing of the preserved biological materials using barrier technology.
    Type: Grant
    Filed: May 6, 1999
    Date of Patent: October 23, 2001
    Assignee: Universal Preservation Technologies, Inc.
    Inventors: Victor Bronshtein, Kevin R. Bracken, Ronnie K. Livers, David R. Williams
  • Antibiotic formulation and use for bacterial infections
    Patent number: 6221388
    Abstract: A liposomal aminoglycoside formulation comprising a neutral lipid, a negatively charged lipids and a sterol. The formulation contains unilamellar vesicles having an average size below 100 nm. A process of making liposomes containing an aminoglycoside is also provided. A method is also provided for the treatment of drug susceptible and drug resistant bacteria.
    Type: Grant
    Filed: September 28, 1999
    Date of Patent: April 24, 2001
    Assignee: Gilead Sciences, Inc.
    Inventors: Evan M. Hersch, Eskild A. Petersen, Richard T. Proffitt, Kevin R. Bracken, Su-Ming Chiang
  • Antibiotic formulation and use for bacterial infections
    Patent number: 5958449
    Abstract: A liposomal aminoglycoside formulation comprising a neutral lipid, a negatively charged lipid and a sterol. The formulation contains unilamellar vesicles having an average size below 100 nm. A process of making liposomes containing an aminoglycoside is provided. A method is also provide for the treatment of drug susceptible and drug resistant bacteria.
    Type: Grant
    Filed: May 21, 1998
    Date of Patent: September 28, 1999
    Assignee: NeXstar Pharmaceuticals, Inc.
    Inventors: Evan M. Hersch, Eskild A. Petersen, Richard T. Proffitt, Kevin R. Bracken, Su-Ming Chiang
  • Antibiotic formulation and use for drug resistant infections
    Patent number: 5759571
    Abstract: A liposomal aminoglycoside formulation comprising a neutral lipid, a negatively charged lipids and a sterol. The formulation contains unilamellar vesicles having an average size below 100 nm. A process of making liposomes containing an aminoglycoside is provided where the hydration temperature is significantly below the transition temperature of the formulation. A method for the treatment of drug susceptible and drug resistant bacteria.
    Type: Grant
    Filed: June 23, 1993
    Date of Patent: June 2, 1998
    Assignee: NeXstar Pharmaceuticals, Inc.
    Inventors: Evan M. Hersch, Eskild A. Petersen, Richard T. Proffitt, Kevin R. Bracken, Su-Ming Chiang
  • Antibiotic formulation and use for drug resistant infections
    Patent number: 5756120
    Abstract: A liposomal aminoglycoside formulation comprising a neutral lipid, a negatively charged lipids and a sterol. The formulation contains unilamellar vesicles having an average size below 100 nm. A process of making liposomes containing an aminoglycoside is provided where the hydration temperature is significantly below the transition temperature of the formulation. A method for the treatment of drug susceptible and drug resistant bacteria.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: May 26, 1998
    Assignee: NeXstar Pharmaceuticals, Inc.
    Inventors: Evan M. Hersch, Eskild A. Petersen, Richard T. Proffitt, Kevin R. Bracken, Su-Ming Chiang
  • Antibiotic formulation and use for drug resistant infections
    Patent number: 5756121
    Abstract: A liposomal aminoglycoside formulation comprising a neutral lipid, a negatively charged lipids and a sterol. The formulation contains unilamellar vesicles having an average size below 100 nm. A process of making liposomes containing an aminoglycoside is provided where the hydration temperature is significantly below the transition temperature of the formulation. A method for the treatment of drug susceptible and drug resistant bacteria.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: May 26, 1998
    Assignee: NeXstar Pharmaceuticals, Inc.
    Inventor: Kevin R. Bracken
  • Film-forming evaporation apparatus
    Patent number: 5028297
    Abstract: A thin-film evaporator for preparing liposomes in commercial quantities provides a film-forming zone of uniform thickness which enables the uniform evaporation of an organic solvent to form a film of uniform thickness, followed by in situ hydration of the film in an aqueous phase by agitation with a rotor.
    Type: Grant
    Filed: June 6, 1990
    Date of Patent: July 2, 1991
    Assignee: Vestar, Inc.
    Inventor: Kevin R. Bracken
  • Method for vesicle formation
    Patent number: 4935171
    Abstract: A single-vessel method is provided for preparing liposomes in commercial quantities by forming a homogeneous and uniform lipid film in a thin-film evaporator by evaporation of the organic solvent, followed by in situ hydration of the film in an aqueous phase by agitation with the rotor.
    Type: Grant
    Filed: January 27, 1989
    Date of Patent: June 19, 1990
    Assignee: Vestar, Inc.
    Inventor: Kevin R. Bracken