Abstract: Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.

Abstract: Various examples are provided related to automated security analysis of baseband firmware. In one example, a system includes a wireless front end and processing circuitry communicatively coupled to the wireless front end and a target device. The processing circuitry can generate mutated packets based upon a device state of the target device; provide the mutated packets for transmission to the target device; receive feedback information from the target device in response to reception of the mutated packets; and identify a firmware flaw associated with the target device in response to the feedback information. In another example, a method includes generating mutated packets based upon a device state of a target device; transmitting the mutated packets to the target device; receiving feedback information from the target device in response to reception of the mutated packets; and identifying a firmware flaw associated with the target device using the feedback information.

Abstract: Various examples are provided related to automated security analysis of baseband firmware. In one example, a system includes a wireless front end and processing circuitry communicatively coupled to the wireless front end and a target device. The processing circuitry can generate mutated packets based upon a device state of the target device; provide the mutated packets for transmission to the target device; receive feedback information from the target device in response to reception of the mutated packets; and identify a firmware flaw associated with the target device in response to the feedback information. In another example, a method includes generating mutated packets based upon a device state of a target device; transmitting the mutated packets to the target device; receiving feedback information from the target device in response to reception of the mutated packets; and identifying a firmware flaw associated with the target device using the feedback information.

Abstract: Rootkit-resistant disks (RRD) label all immutable system binaries and configuration files at installation time. During normal operation, the disk controller inspects all write operations received from the host operating system and denies those made for labeled blocks. To upgrade, the host is booted into a safe state and system blocks can only be modified if a security token is attached to the disk controller. By enforcing immutability at the disk controller, a compromised operating system is prevented from infecting its on-disk image.