Patents by Inventor Kevin R. Guertin

Kevin R. Guertin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Piperididinyl and N-amidinopiperidinyl derivatives
    Publication number: 20040067988
    Abstract: This invention is directed to a compound of formula I which is useful for inhibiting the activity of Factor Xa, by combining said compound with a composition containing Factor Xa. The present invention is also directed to compositions containing compounds of the formula I, methods for their preparation, their use, such as in inhibiting the formation of thrombin or for treating a patient suffering from, or subject to, a disease state associated with a physiologically detrimental excess amount of thrombin.
    Type: Application
    Filed: September 30, 2003
    Publication date: April 8, 2004
    Applicant: AVENTIS PHARMACEUTICALS INC.
    Inventors: Scott I. Klein, Kevin R. Guertin
  • Piperididinyl and N-amidinopiperidinyl derivatives
    Publication number: 20020016339
    Abstract: This invention is directed to a compound of fornula I which is useful for inhibiting the activity of Factor Xa, by combining said compound with a composition containing Factor Xa. The present invention is also directed to compositions containing compounds of the formula I, methods for their preparation, their use, such as in inhibiting the formation of thrombin or for treating a patient suffering from, or subject to, a disease state associated with a physiologically detrimental excess amnount of thrombin.
    Type: Application
    Filed: August 6, 2001
    Publication date: February 7, 2002
    Inventors: Scott I. Klein, Kevin R. Guertin
  • Substituted N-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides
    Patent number: 6323227
    Abstract: This invention relates to compounds of formula which inhibit Factor Xa, to pharmaceutical compositions containing the compounds, and to the use of the compounds for the treatment of patients suffering from conditions which can be ameliorated by the administration of an inhibitor of Factor Xa.
    Type: Grant
    Filed: February 26, 1999
    Date of Patent: November 27, 2001
    Assignee: Aventis Pharmaceuticals Products Inc.
    Inventors: Scott I. Klein, Kevin R. Guertin, Alfred P. Spada, Heinz W. Pauls, Yong Gong, Daniel G. McGarry
  • Piperididinyl and N-amidinopiperidinyl derivatives
    Patent number: 6277865
    Abstract: This invention is directed to a compound of formula I which is useful for inhibiting the activity of Factor Xa, by combining said compound with a composition containing Factor Xa. The present invention is also directed to compositions containing compounds of the formula I, methods for their preparation, their use, such as in inhibiting the formation of thrombin or for treating a patient suffering from, or subject to, a disease state associated with a physiologically detrimental excess amount of thrombin.
    Type: Grant
    Filed: March 22, 1999
    Date of Patent: August 21, 2001
    Assignee: Aventis Pharmaceuticals Products Inc.
    Inventors: Scott I. Klein, Kevin R. Guertin
  • Substituted intermediate compounds for the preparation of n-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides
    Patent number: 6140504
    Abstract: Compounds of the formula: ##STR1##
    Type: Grant
    Filed: February 4, 2000
    Date of Patent: October 31, 2000
    Assignee: Aventis Pharmaceuticals Products Inc.
    Inventors: Scott I. Klein, Kevin R. Guertin, Alfred P. Spada
  • Substituted n-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides
    Patent number: 6080767
    Abstract: The compounds according to the invention are substituted N-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides of formula I herein which exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from certain medical disorders. More especially, they are Factor Xa inhibitors. The present invention is directed to compounds of formula I, compositions containing compounds of formula I, methods for their preparation and their use, which are for treating a patient suffering from, or subject to, conditions which can be ameliorated by the administration of an inhibitor of Factor Xa.
    Type: Grant
    Filed: June 27, 1997
    Date of Patent: June 27, 2000
    Assignee: Aventis Pharmaceuticals Products Inc.
    Inventors: Scott I. Klein, Kevin R. Guertin, Alfred P. Spada