Abstract: One or more techniques and/or systems are disclosed for a transmission variator. The variator receives input power from at least two power sources and provides variable speed output power paths for the transmission. A variator clutch assembly transfers input power to a variator shaft, which drives a planetary gear assembly, including a sun drive gear, planetary gears, and one or more ring gears. The ring gear(s) provide output power to a high output and low output gear assembly. A double reverse tapered spline between the sun drive gear and sun gear to provide forward thrust on the sun gear. A lubrication pin in the planetary gears can provide pressurized lubrication to the planetary gear assembly. A ring gear retention key can be disposed in a spur gear of the high output gear assembly, and ride in a groove in the underside of the ring gear to provide for alignment.

Abstract: A sealing system for multiple fluids includes a transmission housing having a first port and a first opening, an electronic component connected to the transmission housing forming a vent space between the electronic component and the transmission housing, and a seal positioned between the electronic component and the transmission housing. The electronic component includes a first conduit. The seal includes an outer loop maintaining a first fluid outside of the outer loop. The seal includes a first inner loop surrounding the first conduit and positioned inside of the outer loop. The first inner loop maintains a second fluid inside the first inner loop. The first port is in fluid communication with the first conduit. The first opening is positioned inside of the outer loop and outside of the first inner loop. The first opening is in fluid communication with the vent space.

Abstract: A multi-mode CVT for a work vehicle powertrain has a continuously variable power source (CVP), an input arrangement with an input shaft receiving engine power, a variator arrangement with a variator shaft supporting a planetary set, a drop set arrangement with a drop set shaft, and an output arrangement with an output shaft supporting an output component. The input, variator, and drop set arrangements include clutch components with the clutch(es) of the drop set arrangement transmitting CVP power or combined CVP and engine power to the output arrangement to provide a selective gear reduction for transmission of an output power according to a plurality of transmission modes, including a CVP-only mode and a combined engine and CVP split-path mode.

Abstract: A method for spin set bearing setting verification in a preload state on a shaft. An inertia wheel may be disposed on the shaft. The inertia wheel or the shaft is rotated. A first rotational speed is measured at a first time. The inertia wheel may decelerate over time to achieve a second rotational speed measured at a second time. The second speed is less than first speed. The change in time between the first time and the second time is measured. The bearing setting may be adjusted if the change in time is outside a predetermined time range. The bearing setting may remain unchanged if the change in time is within a predetermined time range.

Abstract: One or more techniques and/or systems are disclosed for a clutch configuration and/or clutch operation. The clutch configuration includes an arrangement having a transmission input shaft having a conduit therethrough and a rotating clutch drum configured to rotatably couple to the transmission input shaft and operate independent of the transmission input shaft. The rotating clutch drum has a conduit complementary to the conduit of the transmission input shaft. The clutch arrangement further includes a bearing spacer between the transmission input shaft and the rotating clutch drum, wherein the bearing spacer has a conduit complementary to the conduit of the transmission input shaft and the conduit of the rotating clutch drum. The conduits of the bearing spacer, the transmission input shaft, and the rotating clutch drum define a clutch apply pressure path to control actuation of the rotating clutch drum.

Abstract: A method for spin set bearing setting verification in a preload state on a shaft. An inertia wheel may be disposed on the shaft. The inertia wheel or the shaft is rotated. A first rotational speed is measured at a first time. The inertia wheel may decelerate over time to achieve a second rotational speed measured at a second time. The second speed is less than first speed. The change in time between the first time and the second time is measured. The bearing setting may be adjusted if the change in time is outside a predetermined time range. The bearing setting may remain unchanged if the change in time is within a predetermined time range.

Abstract: A method for spin set bearing setting verification in a preload state on a shaft. An inertia wheel may be disposed on the shaft. The inertia wheel or the shaft is rotated. A first rotational speed is measured at a first time. The inertia wheel may decelerate over time to achieve a second rotational speed measured at a second time. The second speed is less than first speed. The change in time between the first time and the second time is measured. The bearing setting may be adjusted if the change in time is outside a predetermined time range. The bearing setting may remain unchanged if the change in time is within a predetermined time range.

Abstract: A method for spin set bearing setting verification in a preload state on a shaft. An inertia wheel may be disposed on the shaft. The inertia wheel or the shaft is rotated. A first rotational speed is measured at a first time. The inertia wheel may decelerate over time to achieve a second rotational speed measured at a second time. The second speed is less than first speed. The change in time between the first time and the second time is measured. The bearing setting may be adjusted if the change in time is outside a predetermined time range. The bearing setting may remain unchanged if the change in time is within a predetermined time range.

Abstract: Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick, structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.

Abstract: Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick, structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.

Abstract: Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick, structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.

Abstract: The present embodiments relate to compositions and methods for treating the inflammatory response in a tissue or organ, such as the liver, by contacting the tissue with a tissue-specific gap junction inhibitor; and compositions and methods of reducing the toxicity of an agent by administering a gap junction inhibitor either simultaneously or sequentially with exposure to the agent. For example, inhibition of the liver-specific gap junction connexin 32 by 2-aminoethyoxydiphenyl-borate, effectively treats and/or prevents hepatotoxicity.

Abstract: Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick, structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.

Abstract: The present embodiments relate to compositions and methods for treating the inflammatory response in a tissue or organ, such as the liver, by contacting the tissue with a tissue-specific gap junction inhibitor; and compositions and methods of reducing the toxicity of an agent by administering a gap junction inhibitor either simultaneously or sequentially with exposure to the agent. For example, inhibition of the liver-specific gap junction connexin 32 by 2 aminoethyoxydiphenyl-borate, effectively treats and/or prevents hepatotoxicity.

Abstract: Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.

Abstract: Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.

Abstract: Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.

Abstract: Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.

Abstract: The invention provides for translating two-dimensional microfabrication technology into the third dimension. Two-dimensional templates are fabricated using high-resolution molding processes. These templates are then bonded to form three-dimensional scaffold structures with closed lumens. The scaffolds can serve as the template for cell adhesion and growth by cells that are added to the scaffolds through the vessels, holes or pores. These scaffolds can be formed by layering techniques, to interconnect flat template sheets to build up a fully vascularized organ.

Abstract: The invention provides for the translating two-dimensional microfabrication technology into the third dimension. Two-dimensional templates are fabricated using high-resolution molding processes. These templates are then bonded to form three-dimensional scaffold structures with closed lumens. These scaffolds can be formed by layering techniques, to interconnect flat template sheets to build up a full, vascularized organ. Alternatively, such scaffolds can be formed by rolling or folding the templates to form thick three-dimensional constructs.