Abstract: A syringe (10?) for use with a powered injector (20) to inject a fluid into a patient that includes a length of material (1550) adapted to transmit or propagate electromagnetic energy therethrough. The length of material (1550) includes a plurality of indicators (60a-60c) positioned along the length of material. The indicators (60a-60c) are adapted to interact with at least a portion of the energy being propagated through the length of material (1550) of the syringe (10?) in a manner that is detectable. An indicator block (1500) may be disposed over at least a portion of the plurality of indicators (60a-60c). The presence (or absence) of an indicator block (1500) provides or corresponds to information about the syringe (10?) configuration. The indicator(s) (60a-60c) in combination with the indicator blocks (1500) may, for example, provide information about syringe (10?) configuration by the number and/or position thereof.