Abstract: Methods and systems to reduce neurotoxicity associated with the treatment of CD19+ B-cell hyperproliferative disorders are disclosed. Neurotoxicity is reduced by the use of agents that protect CD19+ neurovascular pericytes and/or CD19+ vSMCs from attack by CD19-targeted therapy, and by modification of CD19-targeted therapy to avoid CD19+ pericytes and/or CD19+ vSMCs.

Abstract: An improvement for a phasor fragmentation engine and method, whereby a phasor flipping algorithm is applied when determining fragment phasors for a non-constant envelope modulation signal (e.g. OFDM). The phasor flipping algorithm avoids sharp phase transitions for the fragment phasors, which cause an increase in bandwidth, by performing a comparison of the phasor angle separation between the prior and current time samples. This comparison corresponds to a determination of whether the modulation signal V has passed near or through zero.

Abstract: An improvement for a phasor fragmentation engine and method, whereby a phasor flipping algorithm is applied when determining fragment phasors for a non-constant envelope modulation signal (e.g. OFDM). The phasor flipping algorithm avoids sharp phase transitions for the fragment phasors, which cause an increase in bandwidth, by performing a comparison of the phasor angle separation between the prior and current time samples. This comparison corresponds to a determination of whether the modulation signal V has passed near or through zero.

Abstract: An improvement for a phasor fragmentation engine and method, whereby a phasor flipping algorithm is applied when determining fragment phasors for a non-constant envelope modulation signal (e.g. OFDM). The phasor flipping algorithm avoids sharp phase transitions for the fragment phasors, which cause an increase in bandwidth, by performing a comparison of the phasor angle separation between the prior and current time samples. This comparison corresponds to a determination of whether the modulation signal V has passed near or through zero.

Abstract: A power amplifier receives an input analog signal and generates a corresponding power amplified output analog signal. The power amplifier includes first and second power supply rails, an amplifier circuit, and a switch circuit. The first and second power supply rails are capable of supplying power having respective first and second predetermined levels, and a single predetermined polarity. The amplifier circuit is connected to receive the input analog signal and adapted to generate the output analog signal. Finally, the switch circuit is adapted to selectively connect one of the first and second power supply rails to the amplifier circuit.