Patents by Inventor Kevin R. Turbyfill

Kevin R. Turbyfill has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Artificial invaplex formulated with deacylated lipopolysaccharide
    Patent number: 10881684
    Abstract: Disclosed herein are artificial Invaplexes comprising deacylated lipopolysaccharides and methods of making and using thereof.
    Type: Grant
    Filed: June 26, 2017
    Date of Patent: January 5, 2021
    Assignee: The United States Government as represented by the Secretary of the Army
    Inventors: Robert W. Kaminski, Kevin R. Turbyfill, Edwin V. Oaks, Kristen Clarkson
  • Artificial Invaplex Formulated with Deacylated Lipopolysaccharide
    Publication number: 20190099442
    Abstract: Disclosed herein are artificial Invaplexes comprising deacylated lipopolysaccharides and methods of making and using thereof.
    Type: Application
    Filed: June 26, 2017
    Publication date: April 4, 2019
    Inventors: Robert W. Kaminski, Kevin R. Turbyfill, Edwin V. Oaks, Kristen Clarkson
  • Artificial invaplex
    Patent number: 7780966
    Abstract: An artificial invasin complex is prepared from purified or recombinantly prepared invasins and gram negative bacteria lipopolysaccharides. Typically, IpaB is mixed with IpaC to form a IpaB:IpaC complex. This invasin protein complex is then mixed with the lipopolysaccharide to form an artificial invasin complex. Additional bioactive molecules can be incorporated into the complex during manufacture. This artificial invasin complex is similar in function to native Invaplex 24 or Invaplex 50. The artificial invasin complex has superior immunogenicity properties relative to the native complex and can be tailor made. Its method of preparation lends itself to scale up. The artificial invasin complex can facilitate transport of biomolecules, therapeutics and antibiotics across cell membranes in a manner similar to native Shigella Invaplex.
    Type: Grant
    Filed: March 27, 2007
    Date of Patent: August 24, 2010
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Edwin V. Oaks, Kevin R. Turbyfill, Robert W. Kaminski
  • Artificial invaplex
    Publication number: 20080241196
    Abstract: An artificial invasin complex is prepared from purified or recombinantly prepared invasins and gram negative bacteria lipopolysaccharides. Typically, IpaB is mixed with IpaC to form a IpaB:IpaC complex. This invasin protein complex is then mixed with the lipopolysaccharide to form an artificial invasin complex. Additional bioactive molecules can be incorporated into the complex during manufacture. This artificial invasin complex is similar in function to native Invaplex 24 or Invaplex 50. The artificial invasin complex has superior immunogenicity properties relative to the native complex and can be taylor made. Its method of preparation lends itself to scale up. The artificial invasin complex can facilitate transport of biomolecules, therapeutics and antibiotics across cell membranes in a manner similar to native Shigella Invaplex.
    Type: Application
    Filed: March 27, 2007
    Publication date: October 2, 2008
    Applicant: The U.S.A. as represented by the Secretary of the Army, Walter Reed Army Institute of Research
    Inventors: Edwin V. Oaks, Kevin R. Turbyfill, Robert W. Kaminski
  • Heterologous protection induced by immunization with invaplex vaccine
    Patent number: 7258863
    Abstract: In this application is described a composition, Invaplex, derived from a gram negative bacteria for use in generating an immune response in a subject against one or more heterologous species or strains of gram-negative bacteria.
    Type: Grant
    Filed: May 17, 2002
    Date of Patent: August 21, 2007
    Assignee: United States of America as represented by the Secretary of the Army
    Inventors: Edwin V. Oaks, Kevin R. Turbyfill
  • Heterologous protection induced by immunization with invaplex vaccine
    Publication number: 20020197276
    Abstract: In this application is described a composition, Invaplex, derived from a gram negative bacteria for use in generating an immune response in a subject against one or more heterologous species or strains of gram-negative bacteria.
    Type: Application
    Filed: May 17, 2002
    Publication date: December 26, 2002
    Inventors: Edwin V. Oaks, Kevin R. Turbyfill