Abstract: A method includes receiving patient health data; determining a score using a trained machine learning model; determining a threshold value using an adaptive threshold tuning learning model; comparing the score to the threshold value; and generating an alarm. A computing system includes a processor; and a memory having stored thereon instructions that, when executed by the processor, cause the computing system to: receive patient health data; determine a score using a trained machine learning model; determine a threshold value using an adaptive threshold tuning learning model; compare the score to the threshold value; and generate an alarm. A non-transitory computer readable medium includes program instructions that when executed, cause a computer to: receive patient health data; determine a score using a trained machine learning model; determine a threshold value using an adaptive threshold tuning learning model; compare the score to the threshold value; and generate an alarm.

Abstract: A microfluidic device system includes a channel having an entrance and an exit, a height at the entrance being greater than a height at the exit. The height of the channel may decrease continuously from the height at the entrance to the height at the exit. Cells or particles or beads traveling through the channel become trapped based on their size and/or deformability. A visual sensor captures images of the trapped cells or particles or beads, and image software analyzes the captured images to provide size and/or deformability and/or fluorescence information. A method of fabricating such a microfluidic device includes introducing a glass wafer to an etching solution at a specific rate such that a first end of the glass wafer is etched longer than other portions of the glass wafer.

Abstract: A droplet-based microfluidic rheometer system and method of use for real-time viscosity monitoring of blood coagulation is disclosed. Droplets of blood samples are generated in a microfluidic rheometer, and the size of the droplets is highly correlated to the sample viscosity. The size of the droplets can be determined optically using an inverted light microscope and a camera or using electrodes. The microfluidic rheometer systems provides viscosity measurements in less than a second and consumes less than 1 ?l blood or plasma over an hour period. The viscosity measurements may be displayed and transmitted to the Internet or cloud storage.

Abstract: Devices and techniques for continuously monitoring pressure and simultaneously monitoring changes in blood flow, vascular resistance, and/or vascular behavior are provided. The techniques are employed in measuring intracranial pressure (ICP), while simultaneously measuring cerebral blood flow and/or cerebrovascular resistance or behavior. A sensor device includes an optical and piezoelectric sensing assembly integrated into a deployable ICP monitoring device.

Abstract: A method includes receiving patient health data; determining a score using a trained machine learning model; determining a threshold value using an adaptive threshold tuning learning model; comparing the score to the threshold value; and generating an alarm. A computing system includes a processor; and a memory having stored thereon instructions that, when executed by the processor, cause the computing system to: receive patient health data; determine a score using a trained machine learning model; determine a threshold value using an adaptive threshold tuning learning model; compare the score to the threshold value; and generate an alarm. A non-transitory computer readable medium includes program instructions that when executed, cause a computer to: receive patient health data; determine a score using a trained machine learning model; determine a threshold value using an adaptive threshold tuning learning model; compare the score to the threshold value; and generate an alarm.

Abstract: A method of predicting patient deterioration includes receiving an electronic health record data set of the patient, determining a risk score corresponding to the patient by analyzing the electronic health record data set of the patient using a trained machine learning model, determining a threshold value using an online/reinforcement learning model, comparing the risk score to the threshold value, and when the risk score exceeds the threshold value, generating an alarm. A non-transitory computer readable medium includes program instructions that when executed, cause the computer to receive a list of patients, display selectable patient information corresponding to each of the list of patients according to an ordering established by a feature importance algorithm, receive a selection, retrieve vital sign information corresponding to the selection, and display the vital sign information.

Abstract: A personal respiratory isolation system (PRIS) provides a personal, negative pressure environment for a patient or user that reduces contamination and spread of pathogens exhaled by the patient into the environment. The PRIS includes an enclosure to receive the patient's head (such as a hood and a drape) and a negative pressure source which draws ambient air into the interior of the enclosure and draws air within the enclosure's interior (including the exhalations of the patient, including any contaminants and/or pathogens) out of the enclosure via a fluid port into a container for biohazard processing or disposal. The PRIS may allow positive air pressure therapeutic treatments to be delivered to the patient within the negative pressure environment, and the PRIS may maintain a constant pressure within the interior of the enclosure. The PRIS may include a transparent, hinged face shield for ease of patient observation and/or access.

Abstract: A blood biomarker analysis systems providing fast biomarker identification includes a multimodal bioassay device having a biosensor within a portable pipette-shaped device and using nanoplasmonic barcode detectors, such as formed of antibody conjugated gold nanoparticle arrays (AuNPs), capable of capturing any of a plurality of biomarkers. The biomarker analysis system further includes the pipette-shaped device being smartphone-connected and portable to form a highly accurate, point-of-care bioassay device.

Abstract: A microfluidic device system includes a channel having an entrance and an exit, a height at the entrance being greater than a height at the exit. The height of the channel may decrease continuously from the height at the entrance to the height at the exit. Cells or particles or beads traveling through the channel become trapped based on their size and/or deformability. A visual sensor captures images of the trapped cells or particles or beads, and image software analyzes the captured images to provide size and/or deformability and/or fluorescence information. A method of fabricating such a microfluidic device includes introducing a glass wafer to an etching solution at a specific rate such that a first end of the glass wafer is etched longer than other portions of the glass wafer.

Abstract: A microfluidic device system includes a channel having an entrance and an exit, a height at the entrance being greater than a height at the exit. The height of the channel may decrease continuously from the height at the entrance to the height at the exit. Cells or particles or beads traveling through the channel become trapped based on their size and/or deformability. A visual sensor captures images of the trapped cells or particles or beads, and image software analyzes the captured images to provide size and/or deformability and/or fluorescence information. A method of fabricating such a microfluidic device includes introducing a glass wafer to an etching solution at a specific rate such that a first end of the glass wafer is etched longer than other portions of the glass wafer.

Abstract: A microfluidic device system includes a channel having an entrance and an exit, a height at the entrance being greater than a height at the exit. The height of the channel may decrease continuously from the height at the entrance to the height at the exit. Cells or particles or beads traveling through the channel become trapped based on their size and/or deformability. A visual sensor captures images of the trapped cells or particles or beads, and image software analyzes the captured images to provide size and/or deformability and/or fluorescence information. A method of fabricating such a microfluidic device includes introducing a glass wafer to an etching solution at a specific rate such that a first end of the glass wafer is etched longer than other portions of the glass wafer.

Abstract: A method for noninvasively measuring hemodynamic variables of a person includes physically configuring a sensor to measure the pulse of a person. The sensor generates a pulse waveform indicative of the pulse of the person. A processor obtains the pulse waveform from the sensor and the processor determines a reflection coefficient and reflection delay between an incident and a reflected wave, from which the processor determines the hemodynamic variables of the person from the reflection coefficient and the reflection delay.

Abstract: Quick-deployable medical drapes with included integrated toolkits are provided that allow the medical drape, once deployed, to simultaneously protect an area of a patient in need of a medical procedure and expose tools of the integrated toolkit for immediate access by medical professionals. The integrated toolkits may be of different types that include medical and/or surgical tools for use medical procedures. The medical drapes are formed of fully or partially sterile materials and formed into packages having a stored state, in which the medical drape and toolkit are protected against contamination, and a deployed state, in which the medical drape is placed on the patient and ready for the medical procedure.

Abstract: A blood clot retraction assay device and methods of measuring whole-blood clot retractive forces during coagulation are described. When placed in proximity to a micro-beam, a blood droplet attaches thereto, applying a force to the micro-beam during clot formation. Using Piezoresistive micro-beams or other Piezoresistive components disposed upon such micro-beams, the device measures retractive force of a blood droplet based upon changes in resistance. The sensitivity of such measurements allows use of small quantities of blood for measurement, between 15 microliters and 300 microliters. The device further permits continuous measurement of coagulation, allowing measurement of distinct reaction, contraction development, and fibrinolysis phases for each blood sample.

Abstract: A wearable assembly has a pulse plethysmography (PPG) sensor and a piezoelectric pressure sensor and is attachable to a patient's finger or other area corresponding to a peripheral vascular region, and further includes a signal processor configured to monitor blood flow dependent measurements and pressure measurements over time, comparing these measurements to determine properties of the vascular region, such as vascular resistance of a blood vessel, vascular radius of the blood vessel, vascular stiffness of the vascular region, blood pressure, and/or cardiac vascular power. The signal processor may apply a hysteresis comparison of the sensor outputs, e.g., using an elliptical model, and in some examples may apply an extended Kalman filter for optimizing output of the vascular region properties.

Abstract: Compositions comprising clay minerals and methods for their use in promoting hemostasis are provided. The compositions comprise clay minerals such as bentonite, and facilitate blood clotting when applied to a hemorrhaging wound. Electrospun or electrosprayed materials (e.g. bandages, micron beads, etc.) which include clay minerals, and methods for the treatment of acute hemorrhage, are also provided.

Abstract: A collapsible isolation tent assembly includes a collapsible frame assembly, a flexible skin of impermeable material, and an air exchange arrangement, and further an air pump configured for being connected to the air exchange arrangement to effect a unidirectional air flow through the air exchange arrangement. The air pump has a pump capacity within the range of 85 per minute through 20,000 liters per minute. Openings in the flexible skin or around edges of the collapsible tent allow for an air flow compensating for the unidirectional air flow created by the air pump, and the collapsible isolation tent has a footprint dimensioned to be placed on a support surface for an individual patient, for example a hospital bed. A method for preventing air containing airborne pathogens from contaminating a surrounding space or the interior of the isolation tent involves operating an air pump in fluid communication with the collapsible tent.

Abstract: A method includes receiving raw input signals, analyzing the raw signals using a trained coding architecture including an encoding layer; and displaying an output. A computing system includes a processor and a memory storing instructions that when executed by the processor, cause the computing system to receive raw input signals, analyzing the raw signals using a trained coding architecture and display an output. A non-transitory computer readable medium includes program instructions that when executed cause a computer to receive raw input signals, analyze the raw signals using a trained coding architecture and display an output.

Abstract: An anti-hemorrhage device, and an anti-hemorrhage kit, includes a rigid platform and a compression device adjustably secured to the rigid platform. The kit also includes a gastroesophageal aortic occlusion device.

Abstract: A bioelectrochemical sensor utilizing a nanoporous gold electrode. The bioelectrochemical sensor is suitable for measuring redox in biologic media while having increased resistance to biofouling as compared to conventional electrodes such as planar gold electrodes, due to greater exposed surface area of the three-dimensional ligature structure defining the nanopores. The nanopores have a pore size of 5-100 nm, preferably with an average pore size of less than 50 nm, and more preferably with an average pore size of less than 20 nm.