Abstract: Bone anchor assemblies are disclosed herein that can provide for improved fixation as compared with traditional bone anchor assemblies. An exemplary assembly can include a bracket or wing that extends down from the receiver member and accommodates one or more auxiliary bone anchors that augment the fixation of the assembly's primary bone anchor. Another exemplary assembly can include a plate that is seated between the receiver member and the rod and accommodates one or more auxiliary bone anchors that augment the fixation of the assembly's primary bone anchor. Another exemplary assembly can include a hook that extends out from the receiver member to hook onto an anatomical structure or another implant to augment the fixation of the assembly's primary bone anchor. Surgical methods using the bone anchor assemblies described herein are also disclosed.

Abstract: The present disclosure is directed towards improved systems and methods for large-scale production of nanoparticles used for delivery of therapeutic material. The apparatus can be used to manufacture a wide array of nanoparticles containing therapeutic material including, but not limited to, lipid nanoparticles and polymer nanoparticles. In certain embodiments, continuous flow operation and parallelization of microfluidic mixers contribute to increased nanoparticle production volume.

Abstract: Method for treating a heat exchanger which in operation is used to cool process water which has been in contact with polymer particles. The method includes passing to the process side of the heat exchanger a treatment stream while the heat exchanger is at an elevated temperature compared to the temperature when the heat exchanger is in operation.

Abstract: The present invention relates to processes and apparatus useful for the production of polymer powder, and in particular to processes and apparatus for the degassing of polymer powder.

Abstract: Polymerization unit for producing polymer powder having at least one polymerization reactor for the polymerization of light (co)monomer(s) having less than 7 carbon atoms, and heavy comonomer(s) having at least 7 carbon atoms, and a degassing section including two (and optionally a third) cylindrical degassing vessels in series. Light (co)monomer(s) are degassed in the first degassing vessel (V1) and recovered, and heavy comonomers are degassed in the second degassing vessel (V2) and recovered. The active polymer powder is optionally polished and/or optionally deactivated in the optional third degassing vessel (V3). The cross-sectional area (S2) of the second degassing vessel is greater than 1.5 times the cross-sectional area (S1) of the first degassing vessel [S2>1.5×S1], and vessels V1 and V2 are equipped with a vent recovery unit (VR) for respectively recovering the light (co-)monomer(s) (VR1) and the heavy comonomer(s) (VR2) from the gases exiting the vessels.

Abstract: The present invention relates to processes and apparatus useful for the production of polymer powder, and in particular to processes and apparatus for the degassing of polymer powder.

Abstract: The present invention relates to heat exchangers, and in particular to a method for treatment of a heat exchanger which in operation is used to cool process water which has been in contact with polymer particles, which method comprises passing to the process side of the heat exchanger a treatment stream whilst the heat exchanger is at an elevated temperature compared to the temperature when the heat exchanger is in operation.