Abstract: The invention provides compounds of the formula: (A), pharmaceutically acceptable salts, pharmaceutical compositions thereof and methods of using these compounds, salts, or compositions to treat hyperphosphatemia, chronic kidney disease, and/or the cardiovascular disease associated with chronic kidney disease.

Abstract: Provided herein are pharmaceutically acceptable sodium nitrite and pharmaceutical compositions thereof. Also provided herein are methods for determining the total non-volatile organic carbon in a sodium nitrite-containing sample. Further provided herein are methods for producing pharmaceutically acceptable sodium nitrite. Still further provided herein are methods of treatment comprising the administration of pharmaceutically acceptable sodium nitrite.

Abstract: A system for delivering an implantable medical device includes an outer sheath drive assembly and an actuation shaft drive assembly. The outer sheath drive assembly is configured to cause an outer sheath to translate relative to a handle, and includes an outer sheath drive motor. The actuation shaft drive assembly is configured to cause an actuation shaft to translate relative to the handle, and includes an actuation shaft drive motor. The outer sheath drive motor and/or the actuation shaft drive motor may be removed from the system, and the outer sheath drive assembly and/or the actuation shaft drive assembly may instead be manually driven.

Abstract: A platform for building a plurality of vehicle types is disclosed. In an embodiment, a facility may include a processing system for designing a plurality of definition nodes for a vehicle and identifying a relative position for each definition node. Based on the design, the internal volume and other vehicle parameters can be determined. The facility includes a 3-D printer for additively manufacturing the definition nodes. In an embodiment, a plurality of commercial-off-the-shelf (COTS) parts are acquired and the definition nodes are designed to interface with the COTS parts. The facility may also include a station, or primary location where the major portions of the vehicle are assembled. In another embodiment, multiple such geographically-distributed facilities can be used, such that one facility can manufacture a desired vehicle type on behalf of another facility, e.g., in the event of an overflow.

Abstract: A counter-flow heat exchanger is provided that includes: a first fluid path having a first supply tube connected to a first transition area separating the first fluid path into a first array of first passageways, with the first array of first passageways merging at a first converging area into a first discharge tube; and a second fluid path having a second supply tube connected to a second transition area separating the second fluid path into a second array of second passageways, with the second array of second passageways merge at a second converging area into a second discharge tube. The first passageways and the second passageways have a substantially helical path around the centerline of the counter-flow heat exchanger. Additionally, the first array and the second array are arranged together such that each first passageway is adjacent to at least one second passageway.

Abstract: Embodiments of the invention relate to a turbine assembly including a shroud assembly and a nozzle assembly axially adjacent to each other which both include confronting radial sides and confronting axial ends. A spline connector having a circumferential portion and an axial portion such that the circumferential portion of the spline connector extends across the axial ends and the axial portion of the spline connector extends across the confronting radial sides.

Abstract: Connections between nodes and tubes are provided. An apparatus can include additively manufactured first and second nodes, a tube, and an interconnect connecting the tube to the first and second nodes. An apparatus can include a node having an end portion with inner and outer concentric portions forming an annular gap therebetween, and a tube having an end portion extending into the gap.

Abstract: Provided herein are pharmaceutically acceptable sodium thiosulfate and pharmaceutical compositions thereof. Also provided herein are methods for determining the total non-purgeable organic carbon in a sodium thiosulfate-containing sample. Further provided herein are methods for producing pharmaceutically acceptable sodium thiosulfate. Still further provided herein are methods of treatment comprising the administration of pharmaceutically acceptable sodium thiosulfate.

Abstract: Provided herein are pharmaceutically acceptable sodium thiosulfate and pharmaceutical compositions thereof. Also provided herein are methods for determining the total non-purgeable organic carbon in a sodium thiosulfate-containing sample. Further provided herein are methods for producing pharmaceutically acceptable sodium thiosulfate. Still further provided herein are methods of treatment comprising the administration of pharmaceutically acceptable sodium thiosulfate.

Abstract: A speech recognition platform configured to receive an audio signal that includes speech from a user and perform automatic speech recognition (ASR) on the audio signal to identify ASR results. The platform may identify: (i) a domain of a voice command within the speech based on the ASR results and based on context information associated with the speech or the user, and (ii) an intent of the voice command. In response to identifying the intent, the platform may perform multiple actions corresponding to this intent. The platform may select a target action to perform, and may engage in a back-and-forth dialog to obtain information for completing the target action. The action may include streaming audio to the device, setting a reminder for the user, purchasing an item on behalf of the user, making a reservation for the user or launching an application for the user.

Abstract: Engine components are provided for a gas turbine engines that generate a hot combustion gas flow. The engine component can include a substrate constructed from a CMC material and having a hot surface facing the hot combustion gas flow and a cooling surface facing a cooling fluid flow. The substrate generally defines a film hole extending through the substrate and having an inlet provided on the cooling surface, an outlet provided on the hot surface, and a passage connecting the inlet and the outlet. The engine component can also include a coating on at least a portion of the hot surface and on at least a portion of an inner surface defined within the passage.

Abstract: A system for delivering an implantable medical device includes a handle housing. An outer sheath is coupler secured to a proximal end of an outer sheath that is configured to cover at least a portion of the implantable medical device. An outer sheath drive assembly is operably coupled to the outer sheath coupler and is configured to translate the outer sheath relative to the handle housing. An actuation shaft coupler is secured to a proximal end of an activation shaft. An actuation shaft drive assembly is operably coupled to the actuation shaft coupler and is configured to cause the actuation shaft to translate relative to the handle housing and shift the implantable medical device from a first position and a second position in which the implantable medical device is radially expanded relative to the first position.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example system for delivering an implantable medical device includes an outer shaft and an inner catheter, each having a proximal end, a distal portion and a lumen extending therein, wherein the inner catheter extends within a portion of the outer shaft lumen. The system also includes an actuation shaft extending within a portion of the inner catheter lumen, wherein a distal end of the actuation shaft is coupled to the implantable medical device. The system also includes a guidewire shaft extending within a portion of the inner catheter lumen and a coupling component including a distal end region, a proximal end region and a length, wherein the actuation shaft and the guidewire shaft are coupled to the coupling component such that actuation of the coupling component translates the actuation shaft and the tubular guidewire shaft simultaneously.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example system for delivering an implantable medical device includes a handle member including a seal assembly, wherein the seal assembly includes an outer sheath seal assembly coupled to an outer sheath, the outer sheath including a curved portion, the outer sheath seal assembly being translatable relative to the handle. The seal assembly also includes a first fixed seal assembly fixed relative to the handle, the first fixed seal assembly including a first alignment surface and a compression shaft coupled to the first fixed seal assembly. Additionally, first alignment surface is designed to align the compression shaft with at least a portion of the outer sheath.

Abstract: Provided herein are pharmaceutically acceptable sodium nitrite and pharmaceutical compositions thereof. Also provided herein are methods for determining the total non-volatile organic carbon in a sodium nitrite-containing sample. Further provided herein are methods for producing pharmaceutically acceptable sodium nitrite. Still further provided herein are methods of treatment comprising the administration of pharmaceutically acceptable sodium nitrite.

Abstract: An additively manufactured node is disclosed. A node is an additively manufactured (AM) structure that includes a feature, e.g., a socket, a channel, etc., for accepting another structure, e.g., a tube, a panel, etc. The node can include a node surface of a receptacle extending into the node. The receptacle can receive a structure, and a seal interface on the node surface can seat a seal member between the node surface and the structure to create an adhesive region between the node and the structure, the adhesive region being bounded by the node surface, the structure, and the seal member. The node can also include two channels connecting an exterior surface of the node to the adhesive region. In this way, adhesive can be injected into the adhesive region between the node and the structure, and the adhesive can be contained by the seal member.

Abstract: A method and apparatus for an airfoil in a gas turbine engine can include an outer surface bounding an interior. At least one flow channel can be defined among one or more full-length and partial-length ribs to further define a cooling circuit within the airfoil. The cooling circuit can have at least one tip turn at the partial-length rib, having at least on fastback turbulator disposed at least partially within the tip turn.

Abstract: There is provided inter alia a composition comprising a TNF-alpha binding polypeptide and an IL-6R binding polypeptide.

Abstract: A berry harvester provides flexible cushioned elements and surfaces to limit bruising of the fruit harvested. A chassis defines a picking tunnel that passes over rows of plants. A picking system removes fruit from the plants as the harvester moves along the rows. A catching system configured to receive fruit removed from the plants. The catching system includes resilient catch assemblies on each side of the picking tunnel, each of the catch assemblies at least partially overlapping adjacent catch assemblies. Each of the catch assemblies has an upper surface oriented orthogonally to horizontal and flex upon impact by falling fruit.

Abstract: Embodiments of the present invention provide a computer-implemented method of processing image data for determining seed points with respect to the image data, comprising determining a voting map, wherein said voting map is based on voting locations determined for at least some pixels within the image data, determining a density map, wherein determining said density map comprises determining a weighting for at least some pixels within the voting map, wherein the weighting is determined as a non-linear function based on a value of each of the at least some pixels of the voting map, and determining the seed points in the image data on the density map.