Abstract: The invention provides SARS-2 spike protein designs and uses thereof.

Abstract: In certain aspects the invention provides HIV-1 immunogens, including envelopes (CH0848) and selections there—from, and methods for swarm immunizations using combinations of HIV-1 envelopes.

Abstract: The invention is directed to modified HIV-1 envelopes, compositions comprising these modified envelopes, nucleic acids encoding these modified envelopes, compositions comprising these nucleic acids, and methods of using these modified HIV-1 envelopes and/or these nucleic acids to induce immune responses.

Abstract: In certain aspects the invention provides HIV-1 immunogens, including envelopes (CH0848) and selections therefrom, and methods for swarm immunizations using combinations of HIV-1 envelopes.

Abstract: In certain aspects the invention provides HIV-1 immunogens, including HIV-1 envelope selections from individual CH505, and methods for swarm immunizations using combinations of HIV-1 envelopes.

Abstract: Shear-reduction cushioning devices are provided for the prevention of shear related wounds. Cushioning devices include upper and lower cushioning layers that contact each other through at least one internal shear reduction layer provided between the cushioning layers and extending over a shear reduction region, such that dynamic relative translation of the two cushioning layers is permitted within the shear reduction region while absorbing friction and shear internally. The interface between the cushioning layers (where the shear reduction layer is provided) may be angled relative to an external surface of the cushioning device. The cushioning layers may be attached or attachable to one another beyond the shear reduction region, to limit an amount of relative translation of the cushioning layers and to re-center or reset the cushioning layers after use.

Abstract: Shear-reduction cushioning devices are provided for the prevention of shear related wounds. Cushioning devices include upper and lower cushioning layers that contact each other through at least one internal shear reduction layer provided between the cushioning layers and extending over a shear reduction region, such that dynamic relative translation of the two cushioning layers is permitted within the shear reduction region while absorbing friction and shear internally. The interface between the cushioning layers (where the shear reduction layer is provided) may be angled relative to an external surface of the cushioning device. The cushioning layers may be attached or attachable to one another beyond the shear reduction region, to limit an amount of relative translation of the cushioning layers and to re-center or reset the cushioning layers after use.

Abstract: In certain aspects the invention provides HIV-1 immunogens, including HIV-1 envelope selections from individual CH505, and methods for swarm immunizations using combinations of HIV-1 envelopes.

Abstract: Shear-reduction cushioning devices are provided for the prevention of shear related wounds. Cushioning devices include upper and lower cushioning layers that contact each other through at least one internal shear reduction layer provided between the cushioning layers and extending over a shear reduction region, such that dynamic relative translation of the two cushioning layers is permitted within the shear reduction region while absorbing friction and shear internally. The interface between the cushioning layers (where the shear reduction layer is provided) may be angled relative to an external surface of the cushioning device. The cushioning layers may be attached or attachable to one another beyond the shear reduction region, to limit an amount of relative translation of the cushioning layers and to re-center or reset the cushioning layers after use.

Abstract: A beverage vending machine installation comprising a cabinet and a trolley unit, the cabinet defining a void in which, in use, the trolley unit can be positioned. The cabinet has an opening and at least one door moveable between open and closed positions. A trolley unit comprises at least one beverage vending machine. The trolley unit is moveable relative to the cabinet between an installed position and an uninstalled position. In the installed position the trolley unit is positioned within the void of the cabinet such that at least one door may be closed to allow operation of the vending machine installation. In the uninstalled position, the trolley unit is removed from the cabinet after opening at least one door to allow access to the trolley unit.