Abstract: A computing system and method leverage aggregated information regarding historical medication usage and medication availability to efficiently determine a unified purchasing solution. In a method, an order is received for a quantity of a medication. For a covered entity, a portion of the quantity of the medication that is able to be satisfied pursuant to a 340B program is determined based upon information regarding historical usage of the medication for outpatients and prior purchases under the 340B program. The method also includes determining the portions that are separately able to be satisfied pursuant to a group purchasing organization (GPO) program and a wholesaler/prime vendor program. The method further includes determining a proposed purchasing solution and to cause information regarding the proposed purchasing solution to be provided including information regarding savings based upon the prices of the medication for a respective period of time that was provided by the supplier.