Abstract: Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and/or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

Abstract: A system and method use a protocol implementing a competitive auction with a flat rate entry fee. A user is credited with a preselected, maximum number, of bids per auction. In an initial “warm up” stage, users can join the auction. The auction price decreases when new users join the auction during this stage, as by 0.5%. In an “active stage,” bids are placed within temporal bid windows. Each bid placed decreases the auction price. In a lockout stage, new users are not allowed. A bid window timer remains active. Each user's username is displayed along with each bid. The final bid is the bid that has been placed when the bid window timer expires, and is the winning bid. A strategy is enabled wherein a bidder can receive an item for a reduced price, while not having to place an unlimited number of bids.