Patents by Inventor Kevin Solomon
Kevin Solomon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12037371Abstract: Provided herein are novel proteins and protein domains from newly discovered anaerobic fungal species. The anaerobic fungal species have unique enzymatic capabilities, including the ability to digest diverse lignocellulosic biomass feedstocks and to synthesize secondary metabolites. The scope of the invention encompasses novel engineered proteins comprising glycoside hydrolase enzymes, dockerin domains, carbohydrate binding domains, and polyketide synthase enzymes. The invention further encompasses artificial cellulosomes comprising novel proteins and domains of the invention. The scope of the invention further includes novel nucleic acid sequences coding for the engineered proteins of the invention, and methods of using such engineered organisms to degrade lignocellulosic biomass and to create polyketides.Type: GrantFiled: May 17, 2021Date of Patent: July 16, 2024Assignee: The Regents of the University of CaliforniaInventors: Michelle O'Malley, Kevin Solomon, Charles Haitjema
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Publication number: 20240209382Abstract: Methods and nucleic acid sequences for the synthesis of biotemplates in a non-plant based expression system are provided. Such biotemplates include Barley stripe mosaic virus viral-like particles (BSMV-VLPs) that are capable of self-assembly due to being operatively linked with an origin of self-assembly with the Barley stripe mosaic virus capsid protein (BSMV-CP). Also provided are BSMV-VLPs that are capable of self-assembly due one or more site-directed mutations on the BSMV-CP, and BSMV-VLPs that exhibit enhanced stability due to such site-directed mutation(s).Type: ApplicationFiled: November 21, 2023Publication date: June 27, 2024Inventors: Kevin SOLOMON, Kok Zhi LEE, Akash VAIDYA, Mruthula RAMMOHAN
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Patent number: 11820988Abstract: Methods and nucleic acid sequences for the synthesis of biotemplates in a non-plant based expression system are provided. Such biotemplates include Barley stripe mosaic virus viral-like particles (BSMV-VLPs) that are capable of self-assembly due to being operatively linked with an origin of self-assembly with the Barley stripe mosaic virus capsid protein (BSMV-CP). Also provided are BSMV-VLPs that are capable of self-assembly due one or more site-directed mutations on the BSMV-CP, and BSMV-VLPs that exhibit enhanced stability due to such site-directed mutation(s).Type: GrantFiled: February 28, 2020Date of Patent: November 21, 2023Assignee: Purdue Research FoundationInventors: Kevin Solomon, Kok Zhi Lee, Yu-Hsuan Lee, Michael Harris, Loretta Sue Loesch-Fries
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Publication number: 20210269492Abstract: Provided herein are novel proteins and protein domains from newly discovered anaerobic fungal species. The anaerobic fungal species have unique enzymatic capabilities, including the ability to digest diverse lignocellulosic biomass feedstocks and to synthesize secondary metabolites. The scope of the invention encompasses novel engineered proteins comprising glycoside hydrolase enzymes, dockerin domains, carbohydrate binding domains, and polyketide synthase enzymes. The invention further encompasses artificial cellulosomes comprising novel proteins and domains of the invention. The scope of the invention further includes novel nucleic acid sequences coding for the engineered proteins of the invention, and methods of using such engineered organisms to degrade lignocellulosic biomass and to create polyketides.Type: ApplicationFiled: May 17, 2021Publication date: September 2, 2021Applicant: The Regents of the University of CaliforniaInventors: Michelle O'Malley, Kevin Solomon, Charles Haitjema
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Patent number: 11021524Abstract: Provided herein are novel proteins and protein domains from newly discovered anaerobic fungal species. The anaerobic fungal species have unique enzymatic capabilities, including the ability to digest diverse lignocellulosic biomass feedstocks and to synthesize secondary metabolites. The scope of the invention encompasses novel engineered proteins comprising glycoside hydrolase enzymes, dockerin domains, carbohydrate binding domains, and polyketide synthase enzymes. The invention further encompasses artificial cellulosomes comprising novel proteins and domains of the invention. The scope of the invention further includes novel nucleic acid sequences coding for the engineered proteins of the invention, and methods of using such engineered organisms to degrade lignocellulosic biomass and to create polyketides.Type: GrantFiled: June 10, 2020Date of Patent: June 1, 2021Assignee: The Regents of the University of CaliforniaInventors: Michelle O'Malley, Kevin Solomon, Charles Haitjema
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Publication number: 20200299338Abstract: Provided herein are novel proteins and protein domains from newly discovered anaerobic fungal species. The anaerobic fungal species have unique enzymatic capabilities, including the ability to digest diverse lignocellulosic biomass feedstocks and to synthesize secondary metabolites. The scope of the invention encompasses novel engineered proteins comprising glycoside hydrolase enzymes, dockerin domains, carbohydrate binding domains, and polyketide synthase enzymes. The invention further encompasses artificial cellulosomes comprising novel proteins and domains of the invention. The scope of the invention further includes novel nucleic acid sequences coding for the engineered proteins of the invention, and methods of using such engineered organisms to degrade lignocellulosic biomass and to create polyketides.Type: ApplicationFiled: June 10, 2020Publication date: September 24, 2020Applicant: The Regents of the University of CaliforniaInventors: Michelle O'Malley, Kevin Solomon, Charles Haitjema
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Publication number: 20200277613Abstract: Methods and nucleic acid sequences for the synthesis of biotemplates in a non-plant based expression system are provided. Such biotemplates include Barley stripe mosaic virus viral-like particles (BSMV-VLPs) that are capable of self-assembly due to being operatively linked with an origin of self-assembly with the Barley stripe mosaic virus capsid protein (BSMV-CP). Also provided are BSMV-VLPs that are capable of self-assembly due one or more site-directed mutations on the BSMV-CP, and BSMV-VLPs that exhibit enhanced stability due to such site-directed mutation(s).Type: ApplicationFiled: February 28, 2020Publication date: September 3, 2020Inventors: Kevin Solomon, Kok Zhi Lee, Yu-Hsuan Lee, Michael Harris, Loretta Sue Loesch-Fries
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Patent number: 10717768Abstract: Provided herein are novel proteins and protein domains from newly discovered anaerobic fungal species. The anaerobic fungal species have unique enzymatic capabilities, including the ability to digest diverse lignocellulosic biomass feedstocks and to synthesize secondary metabolites. The scope of the invention encompasses novel engineered proteins comprising glycoside hydrolase enzymes, dockerin domains, carbohydrate binding domains, and polyketide synthase enzymes. The invention further encompasses artificial cellulosomes comprising novel proteins and domains of the invention. The scope of the invention further includes novel nucleic acid sequences coding for the engineered proteins of the invention, and methods of using such engineered organisms to degrade lignocellulosic biomass and to create polyketides.Type: GrantFiled: December 8, 2016Date of Patent: July 21, 2020Assignee: The Regents of the University of CaliforniaInventors: Michelle O'Malley, Kevin Solomon, Charles Haitjema
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Patent number: 10676766Abstract: The invention relates to an engineered eukaryotic microorganism into which a gene encoding an acyl-CoA dehydrogenase is introduced and a method for producing methacrylic acid esters such as MMA and MMA-CoA and precursors thereof using the microorganism.Type: GrantFiled: April 20, 2018Date of Patent: June 9, 2020Assignees: The Regents of the University of California, Mitsubishi Chemical CorporationInventors: Michelle O'Malley, Kevin Solomon, Wataru Mizunashi, Fujio Yu
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Publication number: 20180362597Abstract: Provided herein are novel proteins and protein domains from newly discovered anaerobic fungal species. The anaerobic fungal species have unique enzymatic capabilities, including the ability to digest diverse lignocellulosic biomass feedstocks and to synthesize secondary metabolites. The scope of the invention encompasses novel engineered proteins comprising glycoside hydrolase enzymes, dockerin domains, carbohydrate binding domains, and polyketide synthase enzymes. The invention further encompasses artificial cellulosomes comprising novel proteins and domains of the invention. The scope of the invention further includes novel nucleic acid sequences coding for the engineered proteins of the invention, and methods of using such engineered organisms to degrade lignocellulosic biomass and to create polyketides.Type: ApplicationFiled: December 8, 2016Publication date: December 20, 2018Applicant: The Regents of the University of CaliforniaInventors: Michelle O'Malley, Kevin Solomon, Charles Haitjema
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Publication number: 20180346942Abstract: The invention relates to an engineered eukaryotic microorganism into which a gene encoding an acyl-CoA dehydrogenase is introduced and a method for producing methacrylic acid esters such as MMA and MMA-CoA and precursors thereof using the microorganism.Type: ApplicationFiled: April 20, 2018Publication date: December 6, 2018Applicants: The Regents of the University of California, Mitsubishi Chemical CorporationInventors: Michelle O'MALLEY, Kevin SOLOMON, Wataru MIZUNASHI, Fujio YU
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Patent number: 8835138Abstract: Aspects of the invention relate to the design and construction of Metabolite Valves, such as Glucose Valves, that can be used to divert metabolites from endogenous pathways toward alternative pathways in a cell.Type: GrantFiled: March 30, 2011Date of Patent: September 16, 2014Assignee: Massachusetts Institute of TechnologyInventors: Kevin Solomon, Tae Seok Moon, Kristala Lanett Jones Prather
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Publication number: 20130071894Abstract: Aspects of the invention relate to the design and construction of Metabolite Valves, such as Glucose Valves, that can be used to divert metabolites from endogenous pathways toward alternative pathways in a cell.Type: ApplicationFiled: March 30, 2011Publication date: March 21, 2013Applicant: Massachusetts Institute of TechnologyInventors: Kevin Solomon, Tae Seok Moon, Kristala Lanett Jones Prather