Abstract: A device and method for the separation of a compound or compounds from impurities is described. The device comprises a tube having a mixing apparatus that mixes by convection a feedstock comprising one or more products such that the products can be bound to a resin and then contacted with various buffer solutions. At various distances along the cylindrical module, solutions (e.g., sample products to be purified, buffers, etc.) of various compositions can be sequentially added and removed. The resin particles can be retained within the module by filters or screens at the addition and exit ports. In this way, a slurry of resin particles can be continuously equilibrated, loaded with product, washed of impurities, eluted of processed product(s), stripped, re-equilibrated and recycled for re-use.

Abstract: The present invention is in the field of hemophilia therapy. It relates to a new variant of antihemophilic factor VIII having increased specific activity in comparison to known factor VIII products.

Abstract: The present invention is in the field of hemophilia therapy. It relates to a new variant of antihemophilic factor VIII having increased specific activity in comparison to known factor VIII products.

Abstract: The present invention is in the field of hemophilia therapy. It relates to a new variant of antihemophilic factor VIII having increased specific activity in comparison to known factor VIII products.

Abstract: The present invention is in the field of hemophilia therapy. It relates to a new variant of antihemophilic factor VIII having increased specific activity in comparison to known factor VIII products.

Abstract: The present invention provides a tire monitor apparatus and monitored vehicle tire. A module which monitors tire information is supported by a rubber ply affixed to the inside surface of the tire. The module has electrical components for monitoring tire information by collecting, storing and/or reading information about the tire. A retainer assembly is used to secure the module to the rubber ply such that the module is support within the tire's cavity. The module is mounted to be removed, exchanged, etc. In one embodiment, the monitor module may be isolated from tire loads such that the durability of the monitoring system is improved. The fastener assembly has first parts carried by the rubber ply and second fastener parts built into the module. The first and second fastener parts cooperate to support said module from said rubber ply. The first part may be in the form of a shaft or stem having an axial length which allows the module to be retained at an offset distance from the ply and tire.

Abstract: The present invention provides a tire monitor retainer assembly and monitored vehicle tire. A module which monitors tire information is supported by a rubber ply affixed to the inside surface of the tire. The module has electrical components for monitoring tire information by collecting, storing and/or reading information about the tire. A fastener assembly is used to secure the module to the rubber ply such that the module is support within the tire's cavity. The module is mounted to be isolated from tire loads such that the durability of the monitoring system is improved. The fastener assembly has first parts carried by the rubber ply and second fastener parts built into the module. The first and second fastener parts cooperate to support said module from said rubber ply. The module is made with a retainer opening having edges to receive a fastener device having standoff or indexing elements.

Abstract: An installation kit for installing an absorption device on a piece of equipment and then rendering the device tamper-proof with respect to the damping setting thereof, including an absorption device having an adjustment member for adjusting the damping setting thereof, and locking mechanism for locking the adjustment member after the damping setting has been set to a desired level. The kit also includes an obstruction element to be applied to the locking mechanism for prohibiting access to the locking mechanism. The obstruction element is a mass of deformable material disposed on a sheet material that facilitates alignment of the mass of deformable material with the locking mechanism during transfer of the mass of deformable material into the locking mechanism. The invention also relates to a method of adjusting the damping setting of an absorption device and then rendering the device tamper-proof with respect to the damping setting thereof.

Abstract: In recombinant microorganisms which were rendered capable of converting 2,5-diketo-D-gluconic acid (2,5-DKG) to 2-keto-L-gulonic acid (2-KLG) by transfer of genetic material, the secondary metabolites and metabolic pathways leading to the metabolic diversion of 2-KLG and 2,5-DKG were determined, and the diversion of 2-KLG to L-iodonic acid (IA) or of 2,5-DKG to 5-keto-D-gluconate (5-KDH) was blocked.