Abstract: Provided herein are combinations comprising a glucagon-like peptide-1 receptor (GLP-1R) agonist and a thyroid hormone receptor beta (THR?) agonist and methods comprising administering to a subject in need thereof such combinations.

Abstract: The present application provides compounds that may be used as a glucagon-like peptide-1 receptors (GLP-1R) agonist, or pharmaceutically acceptable salts thereof. Also provided are pharmaceutical compositions containing such compounds, or pharmaceutically acceptable salts thereof. Methods of preparing these compounds and compositions, and methods of using these compounds and compositions to treat or prevent a disease or a condition mediated by GLP-1R, are also provided.

Abstract: Provided herein are methods for treating liver disorders, including non-alcoholic steatohepatitis, and symptoms and manifestations thereof, in a patient which utilize, among others, a combination treatment of an FXR agonist and a THR? agonist.

Abstract: Provided herein are methods for treating liver disorders, including non-alcoholic steatohepatitis, and symptoms and manifestations thereof, in a patient which utilize treatment with a THR-? agonist.

Abstract: A method, system, method and computer program product for retrieving data. Records are retrieved from a hierarchical database. The records are categorized into a plurality of record types. Each record comprises a unique identifier field. A record map contains zero or more entries. Each entry comprises an identifying value, data from at least one record and a set of Boolean flags. Each flag corresponds to a record type. A computer iterates over the retrieved records. Data from each record is stored at an entry in the record map having an identifying value equal to the value included in the unique identifier field of the record. Moreover, the flag in this entry which corresponds to the record type of the record is set. Inner joins and outer joins are then performed using the contents of the record map.

Abstract: Techniques for replicating modified data to a hierarchical database. A first list comprises records included in a set of records before at least one modification thereto. A second list comprises records included in the set of records after the at least one modification thereto. For each pre-modification record included in the first list and each post-modification record included in the second list having equal identifying values, a target record at the database and having a matching identifying value is modified. Specifically, if both records include corresponding indexes, information about a structure pointed to by the pre-modification record is removed from an index included in the target record, and information about a structure pointed to by the post-modification record is added to the index. If neither record includes an index, the target record is modified to contain at least one changed value included in the post-modification record.

Abstract: Techniques for replicating modified data to a hierarchical database. A first list comprises records included in a set of records before at least one modification thereto. A second list comprises records included in the set of records after the at least one modification thereto. For each pre-modification record included in the first list and each post-modification record included in the second list having equal identifying values, a target record at the database and having a matching identifying value is modified. Specifically, if both records include corresponding indexes, information about a structure pointed to by the pre-modification record is removed from an index included in the target record, and information about a structure pointed to by the post-modification record is added to the index. If neither record includes an index, the target record is modified to contain at least one changed value included in the post-modification record.

Abstract: A method, system, method and computer program product for retrieving data. Records are retrieved from a hierarchical database. The records are categorized into a plurality of record types. Each record comprises a unique identifier field. A record map contains zero or more entries. Each entry comprises an identifying value, data from at least one record and a set of Boolean flags. Each flag corresponds to a record type. A computer iterates over the retrieved records. Data from each record is stored at an entry in the record map having an identifying value equal to the value included in the unique identifier field of the record. Moreover, the flag in this entry which corresponds to the record type of the record is set. Inner joins and outer joins are then performed using the contents of the record map.

Abstract: A method for addressing process variability in a build-to-order, mass customization production environment. The method includes receiving an order for a product having a particular configuration defined by the order, initiating a production order specifically assigned to the order, fabricating the product based upon the production order, determining if an unrelated product order contains an identical product item configuration and automatically swapping identical product items contained on unrelated production orders to optimize overall production process objectives.

Abstract: A demand fulfillment system and method that uses customer orders to generate a work schedule and a material delivery schedule for a factory that mass produces items, particularly commodities, built to customer order. The demand fulfillment system enables the manufacturer to operate the factory with minimal in-house inventory of parts and/or raw materials by only scheduling work for which inventory is available. Parts and/or raw materials are requested and delivered to an operation of at least one operation on a manufacturing line in the factory from in-house and external inventory based upon the work scheduled for that operation.

Abstract: A method for addressing process variability in a build-to-order, mass customization production environment. The method includes receiving an order for a product having a particular configuration defined by the order, initiating a production order specifically assigned to the order, fabricating the product based upon the production order, determining if an unrelated product order contains an identical product item configuration and automatically swapping identical product items contained on unrelated production orders to optimize overall production process objectives.

Abstract: An automated data warehouse for a demand fulfillment system to provide current supply and demand for generating a work schedule and a material delivery schedule for manufacturing items built to customer order. The automated data warehouse includes outstanding customer orders for items as an accurate measure of current demand, and a current state of an available inventory of material for producing the items as an accurate measure of current supply. The automated data warehouse includes a continuously updated location of a quantity of material from the time the material is accepted into available inventory, during movements from one material source to another, throughout work-in-progress, until the time that the material is consumed. A work schedule and a material delivery schedule are generated periodically to keep up with consumption of materials and fulfillment of customer orders using the automated data warehouse as the source of current supply and demand.

Abstract: A method, computer system, computer program product, and signal embodied on a carrier wave for scheduling delivery of material to a manufacturer with a plurality of manufacturing lines. Each manufacturing line may include at least one operation, and deliveries are made according to the material requirements for the operation. Parts and/or raw materials are requested and delivered to an operation of at least one operation on a manufacturing line in the factory from in-house and external inventory based upon the work scheduled for that operation. Deliveries are scheduled continuously to allow changes in truck arrival schedules from material sources and changes in material requirements. Requests for materials to be delivered are delayed until the last possible moment for making the request to allow for these changes and to ensure that inventory is stored at a manufacturing line and/or operation for minimum time prior to the time the material is needed.

Abstract: A method for addressing process variability in a build-to-order, mass customization production environment. The method includes receiving an order for a product having a particular configuration defined by the order, initiating a production order specifically assigned to the order, fabricating the product based upon the production order, determining if an unrelated product order contains an identical product item configuration and automatically swapping identical product items contained on unrelated production orders to optimize overall production process objectives.

Abstract: A demand fulfillment system and method to provide current supply and demand to generate a work schedule and a material delivery schedule for manufacturing items, particularly commodities, built to customer order. The demand fulfillment system and method uses outstanding customer orders for items as an accurate measure of current demand, and a current state of an available inventory of material for producing the items as an accurate measure of current supply. Customer orders are considered a source of demand from the time the customer order is received until the customer order is fulfilled. Material available to the factory is considered to be part of supply regardless of location of the material. A work schedule and a material delivery schedule are generated periodically using the current state of the available inventory and outstanding customer orders to keep up with consumption of materials and fulfillment of customer orders.

Abstract: An automated data warehouse for a demand fulfillment system to provide current supply and demand for generating a work schedule and a material delivery schedule for manufacturing items built to customer order. The automated data warehouse includes outstanding customer orders for items as an accurate measure of current demand, and a current state of an available inventory of material for producing the items as an accurate measure of current supply. The automated data warehouse includes a continuously updated location of a quantity of material from the time the material is accepted into available inventory, during movements from one material source to another, throughout work-in-progress, until the time that the material is consumed. A work schedule and a material delivery schedule are generated periodically to keep up with consumption of materials and fulfillment of customer orders using the automated data warehouse as the source of current supply and demand.

Abstract: A demand fulfillment system and method that uses customer orders to generate a work schedule and a material delivery schedule for a factory that mass produces items, particularly commodities, built to customer order. The demand fulfillment system enables the manufacturer to operate the factory with minimal in-house inventory of parts and/or raw materials by only scheduling work for which inventory is available. Parts and/or raw materials are requested and delivered to an operation of at least one operation on a manufacturing line in the factory from in-house and external inventory based upon the work scheduled for that operation.

Abstract: A method, computer system, computer program product, and signal embodied on a carrier wave for scheduling delivery of material to a manufacturer with a plurality of manufacturing lines. Each manufacturing line may include at least one operation, and deliveries are made according to the material requirements for the operation. Parts and/or raw materials are requested and delivered to an operation of at least one operation on a manufacturing line in the factory from in-house and external inventory based upon the work scheduled for that operation. Deliveries are scheduled continuously to allow changes in truck arrival schedules from material sources and changes in material requirements. Requests for materials to be delivered are delayed until the last possible moment for making the request to allow for these changes and to ensure that inventory is stored at a manufacturing line and/or operation for minimum time prior to the time the material is needed.

Abstract: A demand fulfillment system and method to provide current supply and demand to generate a work schedule and a material delivery schedule for manufacturing items, particularly commodities, built to customer order. The demand fulfillment system and method uses outstanding customer orders for items as an accurate measure of current demand, and a current state of an available inventory of material for producing the items as an accurate measure of current supply. Customer orders are considered a source of demand from the time the customer order is received until the customer order is fulfilled. Material available to the factory is considered to be part of supply regardless of location of the material. A work schedule and a material delivery schedule are generated periodically using the current state of the available inventory and outstanding customer orders to keep up with consumption of materials and fulfillment of customer orders.