Abstract: A cartridge, analyzer for use therewith, and system including the cartridge and analyzer. The cartridge is configured to receive a biological fluid to be analyzed and includes a plate defining a main channel, a hemolysis chamber, and an oximetry chamber consecutively interconnected with one another. The analyzer is configured to perform analysis of sample disposed within the main channel, hemolyze sample disposed within the hemolysis chamber, and perform oximetry on sample disposed within the oximetry chamber. The cartridge and analyzer may further include alignment and clamping structures for maintain the cartridge in fixed position and alignment during testing or may further include cooperating features for moving the cartridge relative to the analyzer into a testing position or between various different testing positions.