Patents by Inventor Kevin T. Madden

Kevin T. Madden has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Production of carotenoids in oleaginous yeast and fungi
    Patent number: 9909130
    Abstract: The present invention provides systems for producing engineered oleaginous yeast or fungi that express carotenoids.
    Type: Grant
    Filed: August 15, 2012
    Date of Patent: March 6, 2018
    Assignee: DSM IP Assets B.V.
    Inventors: Richard B. Bailey, Kevin T. Madden, Joshua Trueheart
  • Production of carotenoids in oleaginous yeast and fungi
    Patent number: 9297031
    Abstract: The present invention provides systems for producing engineered oleaginous yeast or fungi that express retinolic compounds.
    Type: Grant
    Filed: February 18, 2014
    Date of Patent: March 29, 2016
    Assignee: DSM IP Assets B.V.
    Inventors: Richard B. Bailey, Kevin T. Madden, Joshua Trueheart, Reed Doten, Maria Mayorga, Joshua Griffin Dunn, Dan Dueppen
  • ORGANIC ACID PRODUCTION BY FUNGAL CELLS
    Publication number: 20150104543
    Abstract: Improved systems for the biological production of organic acids are described.
    Type: Application
    Filed: September 25, 2014
    Publication date: April 16, 2015
    Inventors: Aaron Adriaan WINKLER, Abraham Frederik DE HULSTER, Johannes Pieter VAN DIJKEN, Jacobus Thomas PRONK, Joshua TRUEHEART, Kevin T. MADDEN, Carlos Gancedo RODRIGUEZ, Carmen-Lisset Flores MAURIZ, Antonius Jeroen Adriaan VAN MARIS, Jacob C. HARRISON
  • PRODUCTION OF QUINONE DERIVED COMPOUNDS IN OLEAGINOUS YEAST AND FUNGI
    Publication number: 20140315279
    Abstract: The present invention provides systems for producing engineered oleaginous yeast or fungi that express quinone derived compounds.
    Type: Application
    Filed: December 12, 2013
    Publication date: October 23, 2014
    Applicant: DSM IP ASSETS b.v.
    Inventors: Richard B. Bailey, Kevin T. Madden, Joshua Trueheart
  • PRODUCTION OF CAROTENOIDS IN OLEAGINOUS YEAST AND FUNGI
    Publication number: 20140234928
    Abstract: The present invention provides systems for producing engineered oleaginous yeast or fungi that express retinolic compounds.
    Type: Application
    Filed: February 18, 2014
    Publication date: August 21, 2014
    Applicant: DSM IP ASSETS B.V.
    Inventors: Richard B. Bailey, Kevin T. Madden, Joshua Trueheart, Reed Doten, Maria Mayorga, Joshua Griffin Dunn, Dan Dueppen
  • Production of carotenoids in oleaginous yeast and fungi
    Patent number: 8691555
    Abstract: The present invention provides systems for producing engineered oleaginous yeast or fungi that express carotenoids.
    Type: Grant
    Filed: September 28, 2007
    Date of Patent: April 8, 2014
    Assignee: DSM IP Assests B.V.
    Inventors: Richard B. Bailey, Kevin T. Madden, Joshua Trueheart, Reed Doten, Maria Mayorga, Joshua Griffin Dunn, Dan Dueppen
  • Production of quinone derived compounds in oleaginous yeast and fungi
    Patent number: 8633009
    Abstract: The present invention provides systems for producing engineered oleaginous yeast or fungi that express quinone derived compounds.
    Type: Grant
    Filed: March 20, 2007
    Date of Patent: January 21, 2014
    Assignee: DSM IP Assets B.V.
    Inventors: Richard B. Bailey, Kevin T. Madden, Joshua Trueheart
  • PRODUCTION OF CAROTENOIDS IN OLEAGINOUS YEAST AND FUNGI
    Publication number: 20130045504
    Abstract: The present invention provides systems for producing engineered oleaginous yeast or fungi that express carotenoids
    Type: Application
    Filed: August 15, 2012
    Publication date: February 21, 2013
    Applicant: DSM IP ASSETS B.V.
    Inventors: Richard Bailey, Kevin T. Madden, Joshua Trueheart
  • Production of sterols in oleaginous yeast and fungi
    Patent number: 8367395
    Abstract: The present invention provides methods for production of one or more sterol compounds. Further provided are methods and systems for producing engineered oleaginous yeast or fungi that are capable of production of one or more sterol compounds, and compositions which utilize the produced sterol compound(s).
    Type: Grant
    Filed: September 28, 2007
    Date of Patent: February 5, 2013
    Assignee: DSM IP Assets B.V.
    Inventors: Richard B. Bailey, Joshua Trueheart, Kevin T. Madden
  • Production of carotenoids in oleaginous yeast and fungi
    Patent number: 8288149
    Abstract: The present invention provides systems for producing engineered oleaginous yeast or fungi that express carotenoids.
    Type: Grant
    Filed: October 13, 2010
    Date of Patent: October 16, 2012
    Assignee: DSM IP Assets B.V.
    Inventors: Richard B. Bailey, Kevin T. Madden, Joshua Trueheart
  • PRODUCTION OF CAROTENOIDS IN OLEAGINOUS YEAST AND FUNGI
    Publication number: 20120149886
    Abstract: The present disclosure provides systems for producing engineered oleaginous yeast or fungi that express carotenoids.
    Type: Application
    Filed: April 10, 2009
    Publication date: June 14, 2012
    Applicant: MICROBIA, INC.
    Inventors: Richard B. Bailey, Kevin T. Madden, Joshua Trueheart, Reed Doten, Maria Mayorga, Joshua Griffin Dunn, Dan Dueppen
  • MALIC ACID PRODUCTION IN RECOMBINANT YEAST
    Publication number: 20110045559
    Abstract: The present disclosure relates to modified yeast, wherein the yeast has reduced pyruvate decarboxylase polypeptide (PDC) activity and methods of using such yeast to produce malic and/or succinic acid.
    Type: Application
    Filed: May 19, 2008
    Publication date: February 24, 2011
    Inventors: Aaron Adriaan Winkler, Abraham Frederik De Hulster, Johannes Pieter Van Dijken, Jacobus Thomas Pronk, Joshua Trueheart, Kevin T. Madden, Jacob C. Harrison, Carlos Gancedo Rodriguez, Carmen-Lisset Flores Mauriz
  • PRODUCTION OF CAROTENOIDS IN OLEAGINOUS YEAST AND FUNGI
    Publication number: 20110039299
    Abstract: The present invention provides systems for producing engineered oleaginous yeast or fungi that express carotenoids.
    Type: Application
    Filed: September 28, 2007
    Publication date: February 17, 2011
    Applicant: MICROBIA PRECISION ENGINEERING
    Inventors: Richard B. Bailey, Kevin T. Madden, Joshua Trueheart, Reed Doten, Maria Mayorga, Joshua Griffin Dunn, Dan Dueppen
  • ORGANIC ACID PRODUCTION BY FUNGAL CELLS
    Publication number: 20110039327
    Abstract: Improved systems for the biological production of organic acids are described.
    Type: Application
    Filed: May 19, 2008
    Publication date: February 17, 2011
    Inventors: Aaron Adriaan Winkler, Abraham Frederik De Hulster, Johannes Pieter Van Dijken, Jacobus Thomas Pronk, Joshua Trueheart, Kevin T. Madden, Carlos Gancedo Rodriguez, Carmen-Lisset Flores Mauriz, Antonius Jeroen Adriaan Van Maris, Jacob C. Harrison
  • PRODUCTION OF CAROTENOIDS IN OLEAGINOUS YEAST AND FUNGI
    Publication number: 20110021843
    Abstract: The present invention provides systems for producing engineered oleaginous yeast or fungi that express carotenoids
    Type: Application
    Filed: October 13, 2010
    Publication date: January 27, 2011
    Applicant: MICROBIA, INC.
    Inventors: Richard Bailey, Kevin T. Madden, Joshua Trueheart
  • Production of 1,4 Butanediol in a Microorganism
    Publication number: 20110014669
    Abstract: A biological method for the conversion of L-glutamate to 1,4-butanediol that involves a decarboxylation step and avoids production of 4-hydroxybutyrate as an intermediate is described. The method includes: (a) conversion of L-glutamate to L-glutamate 5-phosphate; (b) conversion of L-glutamate 5-phosphate to L-glutamate 5-semialdehyde; (c) conversion of L-glutamate 5-semialdehyde to 5-hydroxy-L-norvaline; (d) conversion of 5-hydroxy-L-norvaline to 5-hydroxy-2-oxopentanoate; (e) conversion of 5-hydroxy-2-oxopentanoate to 4-hydroxybutanal; and (f) the conversion of 4-hydroxybutanal to 1,4-butanediol.
    Type: Application
    Filed: January 25, 2010
    Publication date: January 20, 2011
    Inventors: Kevin T. Madden, David M. Young, Stanley Bower, Chi-Li Liu
  • Production of carotenoids in oleaginous yeast and fungi
    Patent number: 7851199
    Abstract: The present invention provides systems for producing engineered oleaginous yeast or fungi that express carotenoids.
    Type: Grant
    Filed: March 20, 2006
    Date of Patent: December 14, 2010
    Assignee: Microbia, Inc.
    Inventors: Richard Bailey, Kevin T. Madden, Joshua Trueheart
  • PRODUCTION OF STEROLS IN OLEAGINOUS YEAST AND FUNGI
    Publication number: 20100305341
    Abstract: The present invention provides methods for production of one or more sterol compounds. Further provided are methods and systems for producing engineered oleaginous yeast or fungi that are capable of production of one or more sterol compounds, and compositions which utilize the produced sterol compound(s).
    Type: Application
    Filed: September 28, 2007
    Publication date: December 2, 2010
    Applicant: MICROBIA PRECISION ENGINEERING
    Inventors: Richard Bailey, Joshua Trueheart, Kevin T. Madden
  • PRODUCTION OF QUINONE DERIVED COMPOUNDS IN OLEAGINOUS YEAST AND FUNGI
    Publication number: 20090324800
    Abstract: The present invention provides systems for producing engineered oleaginous yeast or fungi that express quinone derived compounds.
    Type: Application
    Filed: March 20, 2007
    Publication date: December 31, 2009
    Inventors: Richard B. Bailey, Kevin T. Madden, Joshua Trueheart
  • Modulation of secondary metabolite production by zinc binuclear cluster proteins
    Patent number: 7229784
    Abstract: Methods for improving the production of a secondary metabolite by a fungus by increasing the yield or productivity of the secondary metabolite produced by the fungus are described. The methods include increasing the expression of LYS14, for example, by transforming a cell with a nucleic acid molecule encoding LYS14.
    Type: Grant
    Filed: September 19, 2001
    Date of Patent: June 12, 2007
    Assignee: Microbia, Inc.
    Inventors: Douglas Holtzman, Kevin T. Madden, Mary Maxon, Amir Sherman