Patents by Inventor Kevin T. Weber

Kevin T. Weber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterocyclic compound classes for signaling modulation
    Patent number: 10174032
    Abstract: The invention relates to compounds of Formulas I-VII (or pharmaceutically acceptable salts thereof) as defined herein, pharmaceutical compositions thereof, and their use in manufactures and methods for modulating cellular signaling pathways and biological processes associated therewith including inhibition of kinase activity such as PI-3 kinase or inhibition of bromodomain proteins or both at the same time as well as to therapeutic methods for treating a disease associated with aberrant PI3K and/or bromodomain proteins.
    Type: Grant
    Filed: May 4, 2015
    Date of Patent: January 8, 2019
    Assignee: SignalRx Pharmaceuticals, Inc.
    Inventors: Guillermo A Morales, Joseph R. Garlich, Kevin T. Weber, Jessica M. Newblom, Donald L. Durden
  • Novel Heterocyclic Compound Classes for Signaling Modulation
    Publication number: 20150315207
    Abstract: The invention relates to compounds of Formulas I-VII (or pharmaceutically acceptable salts thereof) as defined herein, pharmaceutical compositions thereof, and their use in manufactures and methods for modulating cellular signaling pathways and biological processes associated therewith including inhibition of kinase activity such as PI-3 kinase or inhibition of bromodomain proteins or both at the same time as well as to therapeutic methods for treating a disease associated with aberrant PI3K and/or bromodomain proteins.
    Type: Application
    Filed: May 4, 2015
    Publication date: November 5, 2015
    Applicant: SignalRx Pharmaceuticals, Inc.
    Inventors: Guillermo A Morales, Joseph R. Garlich, Kevin T. Weber, Jessica M. Newblom, Donald L. Durden
  • Thienopyranones as kinase inhibitors
    Patent number: 8557807
    Abstract: The invention, relates to compounds of formula I (or pharmaceutically acceptable salts thereof) as defined herein, pharmaceutical compositions thereof, and their use in manufactures and methods for modulating biological processes including inhibition of kinase activity such as P1-3 kinase.
    Type: Grant
    Filed: January 23, 2009
    Date of Patent: October 15, 2013
    Assignee: Signal Rx Pharmaceuticals, Inc.
    Inventors: Guillermo A. Morales, Kevin T. Weber, Jessica M. Newblom, Xiaodong Peng, Jingdong Su, Joseph R. Garlich
  • 2-[1H-benzimidazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides and 2-[benzothiazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides as kinase inhibitors
    Patent number: 8129396
    Abstract: 2-[1H-benzimidazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides and 2-[benzothiazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides and their salts are kinase inhibitors, useful in the treatment of cancer.
    Type: Grant
    Filed: September 25, 2009
    Date of Patent: March 6, 2012
    Assignee: Telik, Inc.
    Inventors: Natalia Aurrecoechea, Paul P. Beroza, Komath V. Damodaran, Karen Y. Pontius, Louise Robinson, Reyna J. Simon, Truong Vu, Kevin T. Weber
  • Sulfonylethyl phosphorodiamidates
    Patent number: 8093231
    Abstract: Sulfonylethyl and thioethyl phosphorodiamidates, their preparation and intermediates in their preparation, formulations containing them, and their pharmaceutical use. The compounds are useful for treating cancer, alone and in combination with other anticancer therapies.
    Type: Grant
    Filed: July 17, 2007
    Date of Patent: January 10, 2012
    Assignee: Telik, Inc.
    Inventors: David R. Allen, Wenli Ma, Brian T. Peterson, Louise Robinson, Steven R. Schow, Songyuan Shi, Reyna J. Simon, Kevin T. Weber, Michael M. Wick
  • GUANIDINE COMPOUNDS AS ANESTHETICS AND FOR TREATMENT OF NERVOUS SYSTEM DISORDERS
    Publication number: 20110178079
    Abstract: Novel guanidine compounds having the formula in which R1, R2, and R4 are as defined, are effective as sodium channel dockers in neuronal mammalian cells and as anesthetics and/or analgesics, particularly local spinal and/or epidural anesthetics, for alleviation of neuropathic pain, for providing a neuroprotective effect, and for producing anti-convulsant effects.
    Type: Application
    Filed: March 30, 2011
    Publication date: July 21, 2011
    Inventors: Kenneth Drasner, Kevin T. Weber
  • GUANIDINE COMPOUNDS AS ANESTHETICS AND FOR TREATMENT OF NERVOUS SYSTEM DISORDERS
    Publication number: 20110166181
    Abstract: Novel guanidine compounds having the formula in which R1, R2 and R4 are as defined, are effective as sodium channel dockers in neuronal mammalian cells and as anesthetics and/or analgesics, particularly local spinal and/or epidural anesthetics, for alleviation of neuropathic pain, for providing a neuroprotective effect, and for producing anti-convulsant effects.
    Type: Application
    Filed: December 7, 2010
    Publication date: July 7, 2011
    Inventors: Kenneth Drasner, Kevin T. Weber
  • 2-{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates
    Patent number: 7872134
    Abstract: 2-{[2-(Substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates and their salts, their preparation and intermediates in their preparation, pharmaceutical compositions containing them, and methods of treatment using them. The compounds are useful for treating cancer and autoimmune diseases, alone and in combination with other therapies.
    Type: Grant
    Filed: December 12, 2007
    Date of Patent: January 18, 2011
    Assignee: Telik, Inc.
    Inventors: Edgardo Laborde, Andrew B. Kelson, Wenli Ma, Kevin T. Weber
  • Guanidine compounds as anesthetics and for treatment of nervous system disorders
    Patent number: 7868028
    Abstract: Novel guanidine compounds having the formula in which R1, R2 and R4 are as defined, are effective as sodium channel blockers in neuronal mammalian cells and as anesthetics and/or analgesics, particularly local spinal and/or epidural anesthetics, for alleviation of neuropathic pain, for providing a neuroprotective effect, and for producing anti-convulsant effects.
    Type: Grant
    Filed: June 17, 2002
    Date of Patent: January 11, 2011
    Inventors: Kenneth Drasner, Kevin T. Weber
  • THIENOPYRANONES AS KINASE INHIBITORS
    Publication number: 20100310466
    Abstract: The invention, relates to compounds of formula I (or pharmaceutically acceptable salts thereof) as defined herein, pharmaceutical compositions thereof, and their use in manufactures and methods for modulating biological processes including inhibition of kinase activity such as PI-3 kinase.
    Type: Application
    Filed: January 23, 2009
    Publication date: December 9, 2010
    Inventors: Guillermo A. Morales, Kevin T. Weber, Jessica M. Newblom, Xiaodong Peng, Jingdong Su, Joseph R. Garlich
  • 2-[1H-Benzimidazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides and 2-[benzothiazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides as kinase inhibitors
    Publication number: 20100081653
    Abstract: 2-[1H-benzimidazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides and 2-[benzothiazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides and their salts are kinase inhibitors, useful in the treatment of cancer.
    Type: Application
    Filed: September 25, 2009
    Publication date: April 1, 2010
    Inventors: Natalia Aurrecoechea, Paul P. Beroza, Komath V. Damodaran, Karen Y. Pontius, Louise Robinson, Reyna J. Simon, Truong Vu, Kevin T. Weber
  • 2{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N,N',N'-tetrakis(2-chloroethyl)phosphorodiamidates
    Patent number: 7655799
    Abstract: 2-{[2-(Substituted amino)ethyl]sulfonyl}ethyl N,N,N?,N?-tetrakis(2-chloroethyl)-phosphorodiamidates, their preparation and intermediates in their preparation, pharmaceutical compositions containing them, and methods of treatment using them. The compounds are useful for treating cancer, alone and in combination with other anticancer therapies.
    Type: Grant
    Filed: November 29, 2006
    Date of Patent: February 2, 2010
    Assignee: Telik, Inc.
    Inventors: Wenli Ma, Kevin T. Weber, Robert M. Yee
  • 2-ethyl N,N-bis(2-chloroethyl)phosphorodiamidates
    Publication number: 20090156559
    Abstract: 2-{[2-(Substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates and their salts, their preparation and intermediates in their preparation, pharmaceutical compositions containing them, and methods of treatment using them. The compounds are useful for treating cancer and autoimmune diseases, alone and in combination with other therapies.
    Type: Application
    Filed: December 12, 2007
    Publication date: June 18, 2009
    Inventors: Edgardo Laborde, Andrew B. Kelson, Wenli Ma, Kevin T. Weber
  • 2-ETHYL N,N,N',N'-tetrakis(2-chloroethyl)phosphorodiamidates
    Publication number: 20080125398
    Abstract: 2-{[2-(Substituted amino)ethyl]sulfonyl}ethyl N,N,N?,N?-tetrakis(2-chloroethyl)-phosphorodiamidates, their preparation and intermediates in their preparation, pharmaceutical compositions containing them, and methods of treatment using them. The compounds are useful for treating cancer, alone and in combination with other anticancer therapies.
    Type: Application
    Filed: November 29, 2006
    Publication date: May 29, 2008
    Inventors: Wenli Ma, Kevin T. Weber, Robert M. Yee