Abstract: A target sequence of polymer units is estimated from plural series of measurements taken from sequences of polymer units that comprise the target sequence or a complementary sequence. Each measurement is dependent on a k-mer (k polymer units). Models treat the measurements as observations of k-mer states, comprising transition weightings in respect of transitions between successive k-mer states and emission weightings for different measurements being observed. An estimated alignment mapping between the plural series of measurements is derived based on an application of the models to each series. An estimate of the target sequence of polymer units is generated by applying the models, treating the types of k-mer state of each model and the measurements as dimensions of a plural dimensional k-mer state and plural dimensional observations. Constraint of paths through the plural dimensional k-mer states using the derived alignment mapping greatly reduces the required processing.

Abstract: A method and control system for determining and applying stimulation settings for a brain stimulation probe (10, 12) is provided. The brain stimulation probe (10, 12) comprises a plurality of stimulation electrodes (11). The method comprises for multiple stimulation electrodes (11) of the plurality of stimulation electrodes (11): applying a test current and determining a corresponding patient response, determining a volume of influence based (32, 52, 71, 91) on the test current and a position of the stimulation electrode (11), combining the volume of influence (32, 52, 71, 91) and the corresponding patient response with generalized anatomic knowledge of stimulation induced behavior for associating the volume of influence (32, 52, 71, 91) to an anatomic structure (33, 43, 53), and determining an intersection (41, 51) of the volume of influence (32, 52, 71, 91) and the associated anatomic structure (33, 43, 53).

Abstract: A method is provided for visualizing a surgical trajectory (32, 101, 42, 46, 47). The method comprises steps of receiving (71) 3D imaging information (31) of a region to undergo surgery and combining (72) the received 3D imaging information (31) with data from a digitized anatomical atlas. As a result, a combined map of the region to undergo surgery is obtained. The combined map comprises expected positions of anatomical structures (102, 103, 104) in the region to undergo surgery. The method further comprises steps of receiving (73) the surgical trajectory (32, 101, 42, 46, 47) for the surgery, determining (74) positions of intersections (43, 44) of the surgical trajectory (32, 101, 42, 46, 47) with the anatomical structures (102, 103, 104) and providing (75) the positions of the intersections (43, 44) in a coordinate system aligned with the surgical trajectory (32, 101, 42, 46, 47).

Abstract: A method and control system for determining and applying stimulation settings for a brain stimulation probe (10, 12) is provided. The brain stimulation probe (10, 12) comprises a plurality of stimulation electrodes (11). The method comprises for multiple stimulation electrodes (11) of the plurality of stimulation electrodes (11): applying a test current and determining a corresponding patient response, determining a volume of influence based (32, 52, 71, 91) on the test current and a position of the stimulation electrode (11), combining the volume of influence (32, 52, 71, 91) and the corresponding patient response with generalized anatomic knowledge of stimulation induced behavior for associating the volume of influence (32, 52, 71, 91) to an anatomic structure (33, 43, 53), and determining an intersection (41, 51) of the volume of influence (32, 52, 71, 91) and the associated anatomic structure (33, 43, 53).

Abstract: A method is provided for visualizing a surgical trajectory (32, 101, 42, 46, 47). The method comprises steps of receiving (71) 3D imaging information (31) of a region to undergo surgery and combining (72) the received 3D imaging information (31) with data from a digitized anatomical atlas. As a result, a combined map of the region to undergo surgery is obtained. The combined map comprises expected positions of anatomical structures (102, 103, 104) in the region to undergo surgery. The method further comprises steps of receiving (73) the surgical trajectory (32, 101, 42, 46, 47) for the surgery, determining (74) positions of intersections (43, 44) of the surgical trajectory (32, 101, 42, 46, 47) with the anatomical structures (102, 103, 104) and providing (75) the positions of the intersections (43, 44) in a coordinate system aligned with the surgical trajectory (32, 101, 42, 46, 47).