Abstract: In an illustrative embodiment, cell libraries created by rationally designed nucleic acids comprising sequences to facilitate nuclease-directed genome editing events are provided. The cell libraries include saturation mutagenesis cell libraries, promoter swap cell libraries, SNP swap cell libraries, terminator swap cell libraries, and combinations thereof.

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV infection. The invention also relates to methods of treating an RSV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: A trocar assembly includes a cannula assembly, an obturator assembly, and a catch arm. The cannula assembly has a housing, a cannula, and a working channel defining a longitudinal axis from a proximal opening to a distal opening. The obturator assembly includes a proximal head, a distal tip, and a shaft extending therebetween. The catch arm is selectively moveable from a retracted position to a first and second deployed positions and is configured to releasably capture a suture thread. In the retracted position, the catch arm is positioned radially inward from the first deployed position. In the first deployed position, the catch arm is positioned radially outward from the retracted position. In addition, the catch arm is configured to be moved a predetermined distance from the first deployed position to the second deployed position and release the captured suture thread therefrom.

Abstract: A device can receive information associated with dynamically configuring a set of user interface elements associated with a user interface. The device can process the information to determine a manner in which to configure one or more subsets of user interface elements, of the set of user interface elements. The one or more subsets of user interface elements can relate to displaying sports-related information, displaying location-based information, navigating through one or more user interfaces, a homepage user interface, displaying an advertisement, or displaying live content. The device can perform an action to cause the one or more subsets of user interface elements to be configured in the determined manner. The device can detect a modification to the information after performing the action. The device can modify the manner in which the one or more subsets of user interface elements are to be configured based on the modification to the information.

Abstract: A computer-implemented method includes: determining, by a computer device, a value of an operating condition of a component of a vehicle; obtaining, by the computer device, a comparison value for the operating condition from one of: a same type component on the same vehicle; a same type component on at least one other vehicle; and a remote database; comparing, by the computer device, the determined value to the comparison value; determining, by the computer device and based on the comparing, whether the determined value deviates from the comparison value by more than a threshold amount; and generating an alert in the vehicle based on the determining the determined value deviates from the comparison value by more than the threshold amount.

Abstract: A strengthened cover glass or glass-ceramic sheet or article as well as processes and systems for making the strengthened glass or glass-ceramic sheet or article is provided for use in consumer electronic devices. The process comprises cooling the cover glass sheet by non-contact thermal conduction for sufficiently long to fix a surface compression and central tension of the sheet. The process results in thermally strengthened cover glass sheets for use in or on consumer electronic products.

Abstract: An optical system includes an objective of the zoom type and a depth-estimating optical detecting unit, the depth-estimating optical detecting unit including a matrix array of micro-lenses and a matrix-array detector, the matrix array of micro-lenses being arranged so that the image of the focal plane of the zoom is focused by the matrix array of micro-lenses on the plane of the matrix-array detector. The optical system calculates, for a first focal length of the zoom and for a given object, the estimated distance of this object and the measurement uncertainty in this estimation, depending on the first focal length and the estimated distance and, this estimated distance being known, optimizes by allowing at least one second focal length of the zoom to which a lower measurement uncertainty in this estimation corresponds to be determined.

Abstract: An end effector system is disclosed for a robotic system that includes a primary acquisition system that includes a primary end effector, and a secondary retention system that substantially surrounds at least a portion of the primary acquisition system, wherein at least a portion of the primary acquisition system may be drawn up within at least a portion of the secondary retention system such that the primary end effector system may be used to select an object from a plurality of objects, and the secondary retention system may be used to secure the object for rapid transport to an output destination.

Abstract: There is provided a barrier film including a barrier layer having two opposing major surfaces, a first organic layer in direct contact with one of the opposing major surfaces of the barrier layer; a second organic layer in direct contact with the other of the opposing major surfaces of the barrier layer; and a substrate in direct contact with the first organic layer or the second organic layer; wherein the barrier layer comprises buckling deformations with average spacing smaller than average spacing of the buckling deformations in the first or second organic layer.

Abstract: A light source, for example a light emitting diode, can emit light and have an associated optical axis. The source can be deployed in applications where it is desirable to have illumination biased laterally relative to the optical axis, such as in a street luminaire where directing light towards a street is beneficial. The source can be coupled to an optic that comprises a cavity. At least a portion of the cavity can have an outline that is egg-shaped in cross section.

Abstract: A customer may request a service endpoint for a service in their virtual network on a provider network. In response, a service endpoint is generated in the customer's virtual network, a local IP address in the IP address range of the customer's virtual network is assigned to the service endpoint, and a DNS name is assigned to the service endpoint. Resources on the customer's virtual network resolve the DNS name of the service endpoint to obtain the local IP address of the service endpoint and send service requests for the service to the local IP address of the service endpoint. The service endpoint adds routing information to the service requests and sends the service requests over the network substrate to be routed to the service.

Abstract: A hard metal material and a method of manufacturing a component of the hard metal material are disclosed. The hard metal material comprises 5-50 volume % particles of a refractory material dispersed in a host metal. The method comprises forming a slurry of 5-50 volume % particles of the refractory material dispersed in a liquid host metal in an liquid atmosphere and pouring the slurry into a mould and forming a casting of the component.

Abstract: Catalyst systems and methods for making and using the same are provided. The catalyst systems can include a plurality of silica particles and a metallocene catalyst and an activator supported on the plurality of silica particles. The polymerization catalysts have a particle size distribution in which about 10% of the particles have a size less than about 17 to about 23 micrometers, about 50% of the particles have a size less than about 40 to about 45 micrometers, and about 90% of the particles have a size less than about 72 to about 77 micrometers.

Abstract: A method and device are presented for providing patient safe light to a wound. The device includes a radiation source producing flora lethal radiation wavelengths, a radiation conduit detachably optically coupled to the radiation source, and a patch remotely located from the radiation source configured to at least partially conform to a surface contour of the wound. The patch includes a flexible panel formed of a radiation transmitting material able to withstand sterilization, including at least one surface with a disturbed surface area configured to emit radiation upon the wound.

Abstract: A system capable of generating and storing progress data associated with third party services. A voice enabled device may receive voice commands and the system may perform natural language understanding (NLU) to interpret the voice commands, determine a corresponding process and send instructions to a third party server associated with the process. In order to resume the process after the process is interrupted, the system may save and/or cause the third party server to save progress data and/or a checkpoint corresponding to a status of the process at the time that the process is interrupted. The system may use the progress data to resume the process at a later point based on the status. In addition, the system may track processes associated with saved progress data/checkpoints and may interpret incoming voice commands based on the tracked processes.

Abstract: Provided herein are improved methods, compositions, and kits for analysis of nucleic acids. The improved methods, compositions, and kits can enable copy number estimation of a nucleic acid in a sample. Also provided herein are methods, compositions, and kits for determining the linkage of two or more copies of a target nucleic acid in a sample (e.g. whether the two or more copies are on the same chromosome or different chromosomes) or for phasing alleles.

Abstract: Improved methods and apparatus (10, 74) for the solubilization of initially solid humic acids include a large-volume mixing/agitation tank (12, 76) for water and solid humic acids, together a recirculation assembly (14, 78) for continuously recirculating the water/humic acids mixture while reducing the size of the humic acids. Properly used, the apparatus (10, 74) is capable of providing relatively stable, solubilized humic acid solutions or dispersions.

Abstract: System, including methods, apparatus, compositions, and kits, for the mixing of small volumes of fluid by coalescence of multiple emulsions.

Abstract: Embodiments of a catheter insertion device are discussed comprising: an approximately hollow cylindrical catheter sleeve, at whose distal end a catheter is attached; a needle sleeve with a hollow needle, which is attached thereto and which, when ready for use, extends through the catheter sleeve and the catheter, and; a needle protective element that is arranged inside the catheter sleeve while being able to move on the needle. Said needle protective element has an engaging section that engages with an engaging device, which is formed in the vicinity of the needle tip, when the hollow needle is withdrawn from the catheter sleeve. A check valve is placed inside the catheter sleeve between the catheter and the needle protective element. The hollow needle, when ready for use, extends through said check valve, and the check valve automatically closes once the needle is withdrawn.

Abstract: An irrigation system with steady state speeds of movement achieves and maintains substantial straight alignment of multiple interconnected spans with continuous movement over a range of speeds in a forward and reverse movement direction. A variable-speed drive controller monitors and processes the output of the corresponding alignment detector and, based on the output of the alignment detector, selects from memory and continuously furnishes to the corresponding span motor a predetermined progressively increasing speed profile, a predetermined progressively decreasing speed profile, or a new fixed current speed.