Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts, N-oxides, solvates and prodrugs thereof Formula (I) wherein R2, R3, R4, X1, X2, X3 and X4 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy, particularly for use in treating disorders associated with KCNK13 activity.

Abstract: Puzzle kits include a first puzzle and a second puzzle, each of which is formed of a plurality of polyhedral modules, or polyhedrons, connected by hinges in a continuous loop. Each polyhedron includes four faces, six edges, and at least one magnet disposed adjacent to at least one face. Magnetically stabilized assemblies of the first puzzle and the second puzzle form at least a convex polyhedrons, such as a cube.

Abstract: Disclosed herein are liquid cleansing compositions comprising: a. from about 90 percent by volume to about 99 percent by volume of a base liquid soap; b. from about 0.2 percent by volume to about 1.5 percent by volume Citronella oil; c. from about 0.05 percent by volume to about 1.0 percent by volume Peppermint oil; d. from about 0.1 percent by volume to about 1.0 percent by volume Eucalyptus oil; e. from about 0.1 percent by volume to about 1.0 percent by volume Sandalwood oil; f. from about 0.1 percent by volume to about 1.0 percent by volume Lemon oil; and g. from about 0.25 percent by volume to 2.5 percent by volume of an abrasive material, wherein the combined volume percent value of all components does not exceed 100 wt. %, and all volume percent values are based on the total volume of the composition.

Abstract: A door system includes a door jamb, a door panel including a box disposed therealong, a hinge coupling an edge of the door panel to the door jamb, a flexible conduit extending from the door jamb to the edge of the door panel, and a plurality of electronic components. The flexible conduit is configured to facilitate electrically coupling one or more of the plurality of electronic components to an external power source. The plurality of electronic components include a camera disposed within the box, a light integrated into the door jam, a sensor configured to facilitate detecting at least one of sound or activity proximate the door panel, and a backup battery disposed within at least one of the door jamb or the door panel. The backup battery is configured to power at least one of the plurality of electronic components during power loss from the external power source.

Abstract: A light guide member (100, 200, 300, 400) for a power device (10) includes a ring-shaped body (34) adapted to be disposed within a housing (22) of the power device (10). The ring-shaped body (34) has an outer surface (63) that is contoured to complement an inner surface (50) of the housing (22), and includes a light receiving surface (44, 46) and a light emitting surface (48). The ring-shaped body (34) further includes a light coupling portion (42) adapted to accommodate a light source (30, 32) and configured to direct light emitted by the light source (30, 32) to the light receiving surface (44, 46). Light received by the light receiving surface (44, 46) propagates through the ring-shaped body (34) via internal reflection to the light emitting surface (48) where the light is directed out of the light guide member and uniformly illuminates a portion (53) of an outer surface (52) of the housing (22) of the power device (10).

Abstract: A system, for use with a leaflet of a valve of a subject's heart, comprises a catheter, a cutting device, a helical needle, and a suture. The catheter is transluminally advanceable toward the heart. The cutting device is advanceable distally out of the catheter, and is adapted to cut through tissue of the leaflet to form cut tissue and cut edges at the cardiac valve. The helical needle defines a helical lumen, the helical needle configured to be advanced distally out of the catheter and to rotationally extend through, and secure together, two tissue segments of the leaflet. The suture extends through the helical lumen of the helical needle. The helical needle and the suture are configured to extend along the two tissue segments of the leaflet to suture the two tissue segments to each other. Other embodiments are also described.

Abstract: This disclosure describes techniques for diagnosing a presence or malfunction of a network node. In an example method, a first network node receives an indication of a diagnostic transmission originating from a second network node. The second network node further receives a forwarded transmission corresponding to the diagnostic transmission. The first network node diagnoses at least one of a presence or a malfunction of an intermediary node between the first network node and the second network node based on at least one of the indications of the diagnostic transmission or the forwarded transmission.

Abstract: Burner tubes for gas grills are disclosed. An example burner tube includes an open front end, a closed rear end located opposite the open front end, opposing upper and lower surfaces extending between the open front end and the closed rear end, opposing right and left side surfaces extending between the upper surface and the lower surface and between the open front end and the closed rear end, and a hollow interior defined by the upper surface, the lower surface, the right side surface, and the left side surface. The hollow interior has a rectangular cross-sectional profile that tapers in a direction moving from the open front end toward the closed rear end. The burner tube further includes a plurality of gas ports extending upwardly from the upper surface, with each one of the gas ports having an exit opening raised above the upper surface.

Abstract: An oleogel composition comprises an ethylcellulose polymer, a first, non-volatile oil which is an active ingredient and a second oil selected from the group consisting of triglyceride oils and mineral oils.

Abstract: A base station may generate and transmit a transport stream including a sequence of frames. A frame may include a plurality of partitions, where each partition includes a corresponding set of OFDM symbols. For each partition, the OFDM symbols in that partition may have a corresponding cyclic prefix size and a corresponding FFT size, allowing different partitions to be targeted for different collections of user devices, e.g., user devices having different expected values of maximum delay spread and/or different ranges of mobility. The base station may also dynamically re-configure the sample rate of each frame, allowing further resolution in control of subcarrier spacing. By allowing the cyclic prefixes of different OFDM symbols to have different lengths, it is feasible to construct a frame that confirms to a set payload duration and has arbitrary values of cyclic prefix size per partition and FFT size per partition. The partitions may be multiplexed in time and/or frequency.

Abstract: An anti-reflective waveguide assembly comprising a waveguide substrate having a first index of refraction, a plurality of diffractive optical elements disposed upon a first surface of the waveguide and an anti-reflective coating disposed upon a second surface of the waveguide. The anti-reflective coating preferably increases absorption of light through a surface to which it is applied into the waveguide so that at least 97 percent of the light is transmitted. The anti-reflective coating is composed of four layers of material having different indices of refraction that the first index of refraction and an imaginary refractive index less than 1×10?3 but preferably less than 5×10?4.

Abstract: Methods and systems are disclosed for displaying an augmented reality virtual object on a multimedia device. One method comprises detecting, in an augmented reality environment displayed using a first device, a virtual object; detecting, within the augmented reality environment, a second device, the second device comprising a physical multimedia device; and generating, at the second device, a display comprising a representation of the virtual object.

Abstract: Provided is a polymerizable composition including (a) a polymerizable component comprising a diol bis(allyl carbonate) and/or a pre-polymer thereof; and (b) a polymerization initiator component including: (i) a di(C6-C10 alkyl) peroxydicarbonate, and (ii) an organic peroxide having one peroxy, one peroxycarbonate, or one peroxybenzoate group and a 1,1-dimethylalkyl group bonded to a peroxy oxygen, where (ii) comprises a molecular weight ranging from 200 to 250 g/mole, the polymerization initiator (b) is free of diisopropyl peroxydicarbonate, (i) comprises an amount ranging from 4.87% to 7.90% by weight relative to the total solids of the polymerizable composition and (ii) comprises an amount within the range defined by the following formula: (4.406X2?0.592X+0.021)?Y?(0.726X2?0.121X+0.009) where X corresponds to the weight fraction of (i) and Y corresponds to the weight fraction of (ii). Also provided is a method of making an optical article from the polymerizable composition.

Abstract: Embodiments are directed to a platform for zebrafish phenotyping that includes a user, images and videos containing zebrafish and elements pertaining to the zebrafish (such as organs, organ systems, and tissues), a first set of machine learning models used to predict zebrafish phenotypes based on the image and video data, and a second set of machine learning models used to automatically detect elements in one of the images and videos containing zebrafish. This platform may be used to detect changes in phenotypes and may be used to detect alteration is specific organs in zebrafish.

Abstract: In some embodiments, generating synthetic training datasets for training machine learning models in training data-sparse environments for non-homogenous predictions may be facilitated. In some embodiments, user-specific information associated with a user may be received. The system may generate synthetic training data representing one or more alternative actions corresponding to one or more characteristics by: labeling the user-specific information, determining (e.g., based on the labeled user-specific information) one or more characteristics of the labeled user-specific information, and determining (e.g., based on the one or more characteristics) one or more alternative actions corresponding to the one or more characteristics. The system may then train a machine learning model based on the synthetic training data to generate a prediction in response to providing an action of a first user to the machine learning model.

Abstract: Techniques are disclosed to use a robotic arm to palletize or depalletize diverse items. In various embodiments, data associated with a plurality of items to be stacked on or in a destination location is received. A plan to stack the items on or in the destination location is generated based at least in part on the received data. The plan is implemented at least in part by controlling a robotic arm of the robot to pick up the items and stack them on or in the receptacle according to the plan, including by for each item: using one or more first order sensors to move the item to a first approximation of a destination position for that item at the destination location; and using one or more second order sensors to snug the item into a final position.

Abstract: Example methods and devices for touch-down detection for a robotic device are described herein. In an example embodiment, a computing system may receive a force signal due to a force experienced at a limb of a robotic device. The system may receive an output signal from a sensor of the end component of the limb. Responsive to the received signals, the system may determine whether the force signal satisfies a first threshold and determine whether the output signal satisfies a second threshold. Based on at least one of the force signal satisfying the first threshold or the output signal satisfying the second threshold, the system of the robotic device may provide a touch-down output indicating touch-down of the end component of the limb with a portion of an environment.

Abstract: A lubricant in dry form, which can be blended with other dry additives such as bentonite, or polymers like xanthan, PAC, and PHPA. The lubricant in dry form may allow for handling at low temperatures with no pour point issues in aqueous situations, which will reduce the torque and ensure a good penetration rate.

Abstract: A computing system receives data for a game. The data includes at least one of tracking data or event data. Based on the data for the game, the computing system determines that an event has occurred within the game. Based on the determining, the computing system generates a graphic responsive to the event. The graphic includes insights related to the event. The computing system recommends an image relevant to the event based on metatags associated with the event. The computing system generates a visual element by merging the image and the graphic.

Abstract: Disclosed herein are dual-textured glass articles. The glass articles may include a glass substrate comprising a first major surface and a second major surface. The first major surface may be opposite the second major surface. At least a portion of the first major surface comprises a dual-texture. The dual-texture may comprise a plurality of first features and a plurality of second features. The plurality of first features comprise protrusions from the first major surface and the plurality of second features comprise indentations in the first major surface and indentations in the plurality of first features.